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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADE1
  • nucleus
  • cytoplasm
  • purine nucleotide biosynthetic process
  • response to drug
  • 'de novo' IMP biosynthetic process
  • phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
  • GCD1
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • GCD2
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • GCD6
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • GCD7
  • mitochondrion
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • GCN3
  • guanyl-nucleotide exchange factor complex
  • eukaryotic translation initiation factor 2B complex
  • regulation of translational initiation
  • translation initiation factor activity
  • guanyl-nucleotide exchange factor activity
  • enzyme regulator activity
  • MRF1
  • mitochondrion
  • translational termination
  • translation
  • translation release factor activity
  • MRH4
  • mitochondrion
  • ribosome biogenesis
  • RNA helicase activity
  • SUI2
  • multi-eIF complex
  • cytoplasm
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 2B complex 3.0713E-15 10 5 5 6292
    guanyl-nucleotide exchange factor complex 6.4413E-14 10 7 5 6292
    eukaryotic translation initiation factor 2 complex 6.8153E-6 10 3 2 6292
    multi-eIF complex 6.3341E-5 10 8 2 6292
    protein complex 4.4574E-4 10 1137 7 6292
    cytoplasmic part 1.4804E-3 10 2482 9 6292
    cytoplasm 3.2692E-3 10 3552 10 6292
    macromolecular complex 4.416E-3 10 1635 7 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translational initiation 4.1323E-14 10 42 7 6292
    regulation of translational initiation 1.4133E-12 10 11 5 6292
    translation 6.1286E-9 10 376 8 6292
    regulation of translation 1.2423E-8 10 57 5 6292
    posttranscriptional regulation of gene expression 1.7604E-8 10 61 5 6292
    regulation of cellular protein metabolic process 3.0702E-8 10 68 5 6292
    regulation of protein metabolic process 4.7255E-8 10 74 5 6292
    cellular protein metabolic process 2.2894E-5 10 1074 8 6292
    cellular biosynthetic process 2.8141E-5 10 1567 9 6292
    biosynthetic process 3.4126E-5 10 1602 9 6292
    protein metabolic process 3.5183E-5 10 1136 8 6292
    cellular macromolecule biosynthetic process 4.9194E-5 10 1187 8 6292
    macromolecule biosynthetic process 4.9829E-5 10 1189 8 6292
    gene expression 8.885E-5 10 1283 8 6292
    regulation of gene expression 3.2368E-4 10 445 5 6292
    regulation of macromolecule biosynthetic process 3.6311E-4 10 456 5 6292
    regulation of cellular biosynthetic process 4.2695E-4 10 472 5 6292
    regulation of biosynthetic process 4.3121E-4 10 473 5 6292
    regulation of macromolecule metabolic process 4.9911E-4 10 488 5 6292
    regulation of primary metabolic process 6.3595E-4 10 514 5 6292
    regulation of cellular metabolic process 7.7276E-4 10 536 5 6292
    regulation of metabolic process 8.4907E-4 10 547 5 6292
    regulation of cellular process 4.6602E-3 10 796 5 6292
    primary metabolic process 5.4001E-3 10 2896 9 6292
    regulation of biological process 5.4298E-3 10 824 5 6292
    cellular macromolecule metabolic process 6.225E-3 10 2285 8 6292
    macromolecule metabolic process 7.5629E-3 10 2349 8 6292
    cellular metabolic process 7.9165E-3 10 3033 9 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation factor activity, nucleic acid binding 1.3016E-16 10 44 8 6292
    translation initiation factor activity 1.3688E-15 10 27 7 6292
    guanyl-nucleotide exchange factor activity 1.5082E-9 10 38 5 6292
    GTPase regulator activity 8.9959E-8 10 84 5 6292
    nucleoside-triphosphatase regulator activity 1.676E-7 10 95 5 6292
    nucleic acid binding 5.6169E-7 10 666 8 6292
    enzyme regulator activity 8.0911E-6 10 207 5 6292
    binding 9.4788E-5 10 1294 8 6292
    phosphoribosylaminoimidazolesuccinocarboxamide synthase activity 1.5893E-3 10 1 1 6292
    translation release factor activity 4.7611E-3 10 3 1 6292
    translation termination factor activity 6.3436E-3 10 4 1 6292

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