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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CSE2
  • nucleus
  • mediator complex
  • mitotic sister chromatid segregation
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • GAL11
  • nucleus
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED1
  • nucleus
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED11
  • mediator complex
  • transcription from RNA polymerase II promoter
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
  • MED2
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED4
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED6
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED7
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED8
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • NUT2
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • PGD1
  • nucleus
  • mediator complex
  • response to drug
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • ROX3
  • nucleus
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SOH1
  • nucleus
  • DNA repair
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • molecular_function
  • SRB2
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB4
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB5
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB7
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mediator complex 1.5373E-40 17 18 15 6292
    nucleoplasm part 5.9728E-20 17 245 15 6292
    nucleoplasm 1.8798E-19 17 264 15 6292
    nuclear lumen 6.917E-16 17 453 15 6292
    organelle lumen 1.9704E-13 17 660 15 6292
    intracellular organelle lumen 1.9704E-13 17 660 15 6292
    membrane-enclosed lumen 4.7435E-13 17 700 15 6292
    nuclear part 4.0003E-10 17 1103 15 6292
    protein complex 6.2494E-10 17 1137 15 6292
    nucleus 4.6591E-9 17 2041 17 6292
    macromolecular complex 1.2396E-7 17 1635 15 6292
    organelle part 1.429E-5 17 2282 15 6292
    intracellular organelle part 1.429E-5 17 2282 15 6292
    membrane-bounded organelle 1.6371E-4 17 3771 17 6292
    intracellular membrane-bounded organelle 1.6371E-4 17 3771 17 6292
    intracellular organelle 6.0057E-4 17 4070 17 6292
    organelle 6.0308E-4 17 4071 17 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription from RNA polymerase II promoter 1.5013E-22 17 335 17 6292
    transcription, DNA-dependent 1.7295E-19 17 503 17 6292
    RNA biosynthetic process 2.0517E-19 17 508 17 6292
    transcription 8.6073E-19 17 552 17 6292
    RNA metabolic process 1.0472E-14 17 954 17 6292
    cellular macromolecule biosynthetic process 4.4224E-13 17 1187 17 6292
    macromolecule biosynthetic process 4.5517E-13 17 1189 17 6292
    gene expression 1.6734E-12 17 1283 17 6292
    nucleic acid metabolic process 8.9319E-12 17 1415 17 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.0536E-11 17 1566 17 6292
    cellular biosynthetic process 5.109E-11 17 1567 17 6292
    biosynthetic process 7.4517E-11 17 1602 17 6292
    cellular nitrogen compound metabolic process 4.0932E-10 17 1770 17 6292
    nitrogen compound metabolic process 5.0065E-10 17 1791 17 6292
    cellular macromolecule metabolic process 3.1999E-8 17 2285 17 6292
    macromolecule metabolic process 5.1262E-8 17 2349 17 6292
    primary metabolic process 1.8202E-6 17 2896 17 6292
    cellular metabolic process 4.0023E-6 17 3033 17 6292
    metabolic process 7.9234E-6 17 3157 17 6292
    anatomical structure homeostasis 6.7742E-5 17 286 6 6292
    telomere organization 6.7742E-5 17 286 6 6292
    telomere maintenance 6.7742E-5 17 286 6 6292
    chromosome organization 3.5455E-4 17 555 7 6292
    homeostatic process 4.7976E-4 17 408 6 6292
    regulation of biological quality 2.3449E-3 17 551 6 6292
    cellular process 2.5051E-3 17 4426 17 6292
    DNA metabolic process 3.1865E-3 17 585 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase II transcription mediator activity 4.4788E-42 17 22 16 6292
    general RNA polymerase II transcription factor activity 2.914E-32 17 64 16 6292
    RNA polymerase II transcription factor activity 7.176E-27 17 130 16 6292
    transcription regulator activity 5.8026E-20 17 339 16 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle