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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 18 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CSE2
  • nucleus
  • mediator complex
    		•
  • mitotic sister chromatid segregation
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    GAL11
  • nucleus
  • mediator complex
    		•
  • telomere maintenance
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    MED1
  • nucleus
  • mediator complex
    		•
  • telomere maintenance
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    MED11
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
    		•
    MED2
  • nucleus
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    MED4
  • nucleus
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    MED6
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    MED7
  • nucleus
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    MED8
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    NUT2
  • nucleus
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    PGD1
  • nucleus
  • mediator complex
    		•
  • response to drug
  • telomere maintenance
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    ROX3
  • nucleus
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    SIN4
  • nucleus
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    SRB2
  • mediator complex
    		•
  • telomere maintenance
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    SRB4
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    SRB5
  • mediator complex
    		•
  • telomere maintenance
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•
    SRB6
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
    		•
    SRB7
  • nucleus
  • mediator complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription mediator activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    mediator complex 3.1012E-48 18 18 17 6292
    nucleoplasm part 1.0946E-23 18 245 17 6292
    nucleoplasm 4.0507E-23 18 264 17 6292
    nuclear lumen 4.7583E-19 18 453 17 6292
    organelle lumen 3.0413E-16 18 660 17 6292
    intracellular organelle lumen 3.0413E-16 18 660 17 6292
    membrane-enclosed lumen 8.3132E-16 18 700 17 6292
    nuclear part 1.8955E-12 18 1103 17 6292
    protein complex 3.1682E-12 18 1137 17 6292
    macromolecular complex 1.4375E-9 18 1635 17 6292
    nucleus 1.5028E-9 18 2041 18 6292
    organelle part 3.7122E-7 18 2282 17 6292
    intracellular organelle part 3.7122E-7 18 2282 17 6292
    membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    intracellular membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    intracellular organelle 3.879E-4 18 4070 18 6292
    organelle 3.8963E-4 18 4071 18 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    transcription from RNA polymerase II promoter 7.6082E-24 18 335 18 6292
    transcription, DNA-dependent 1.3395E-20 18 503 18 6292
    RNA biosynthetic process 1.6054E-20 18 508 18 6292
    transcription 7.3385E-20 18 552 18 6292
    RNA metabolic process 1.5637E-15 18 954 18 6292
    cellular macromolecule biosynthetic process 8.2458E-14 18 1187 18 6292
    macromolecule biosynthetic process 8.5013E-14 18 1189 18 6292
    gene expression 3.3762E-13 18 1283 18 6292
    nucleic acid metabolic process 1.9899E-12 18 1415 18 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.2475E-11 18 1566 18 6292
    cellular biosynthetic process 1.262E-11 18 1567 18 6292
    biosynthetic process 1.8822E-11 18 1602 18 6292
    cellular nitrogen compound metabolic process 1.1435E-10 18 1770 18 6292
    nitrogen compound metabolic process 1.4154E-10 18 1791 18 6292
    cellular macromolecule metabolic process 1.1566E-8 18 2285 18 6292
    macromolecule metabolic process 1.9051E-8 18 2349 18 6292
    primary metabolic process 8.3514E-7 18 2896 18 6292
    cellular metabolic process 1.9237E-6 18 3033 18 6292
    metabolic process 3.9649E-6 18 3157 18 6292
    anatomical structure homeostasis 9.8448E-4 18 286 5 6292
    telomere organization 9.8448E-4 18 286 5 6292
    telomere maintenance 9.8448E-4 18 286 5 6292
    cellular process 1.7601E-3 18 4426 18 6292
    chromosome organization 3.3825E-3 18 555 6 6292
    homeostatic process 4.7344E-3 18 408 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA polymerase II transcription mediator activity 2.0088E-49 18 22 18 6292
    general RNA polymerase II transcription factor activity 9.8906E-38 18 64 18 6292
    RNA polymerase II transcription factor activity 1.4048E-31 18 130 18 6292
    transcription regulator activity 9.4732E-24 18 339 18 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle