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Protein Overview: ELC1

General Information:
Name(s) found: ELC1 / YPL046C [SGD]
Description(s) found:
Found 36 descriptions.
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  • Elongin C, involved in transcription elongation as a heterodimer with Ela1p; required for ubiquitin-dependent degradation of Rpo21p; plays a role in global genomic nucleotide excision repair; expression highly upregulated during sporulation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 99 amino acids

    Gene Ontology:
    Cellular Component: transcription elongation factor complex [ISSLink to PubMed article]
    Cul3-RING ubiquitin ligase complex [IMPLink to PubMed article]
    nucleotide-excision repair factor 4 complex [IDALink to PubMed article]
    Biological Process: nucleotide-excision repair, DNA damage recognition [IMPLink to PubMed article]
    protein ubiquitination during ubiquitin-dependent protein catabolic process [IMPLink to PubMed article]
    RNA elongation from RNA polymerase II promoter [ISSLink to PubMed article]
    Molecular Function: transcription elongation regulator activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQDFVTLVS KDDKEYEISR SAAMISPTLK AMIEGPFRES KGRIELKQFD SHILEKAVEY  60
   61 LNYNLKYSGV SEDDDEIPEF EIPTEMSLEL LLAADYLSI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ELC1 RAD7
    View Details Krogan NJ, et al. (2006) ELC1 RAD7
    View Details Ho Y, et al. (2002) ELC1 RAD7 UBI4
    View Details Qiu et al. (2008) ABF1 CDC73 CHD1 CTR9 DST1 ELA1 ELC1 ELP3 ELP6 IKI1 IKI3 LEO1 PAF1 RAD14 RAD16 RAD3 RAD4 RAD7 RTF1 SPN1 SPT16 SPT4 SPT6 SSL1 SSL2 TFB1 TFB3 TFB5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ELC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..47] PSI-BLAST 452.522879 Elongin C
    2 View Details [48..99] PSI-BLAST 452.522879 Elongin C

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription elongation regulator activity
    		•  7.53002625989446 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  6.78934422958647 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.52079977531395 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  5.78412146341235 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.95822114853319 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.03732153795237 bayes_pls_golite062009
  • DNA binding
    		•  3.26500171477452 bayes_pls_golite062009
  • binding
    		•  3.25487903155187 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.97922606919142 bayes_pls_golite062009
  • transcription factor activity
    		•  2.57500386784378 bayes_pls_golite062009
  • ligase activity
    		•  1.75579073151181 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.71028791830657 bayes_pls_golite062009
  • protein binding
    		•  1.59297029384664 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.933012980583336 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.784594789263781 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.318894446962849 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.292746639637876 bayes_pls_golite062009
  • potassium channel activity
    		•  0.288501096353748 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.189580737604762 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.172889160336679 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.16355432097396 bayes_pls_golite062009
  • cation channel activity
    		•  0.158179353838005 bayes_pls_golite062009
  • catalytic activity
    		•  0.112500532859479 bayes_pls_golite062009
  • gated channel activity
    		•  0.0585265912733182 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.033499769837058 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle