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Protein Overview: MET5

General Information:
Name(s) found: MET5 / YJR137C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1442 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article][TASLink to PubMed article]
    sulfite reductase complex (NADPH) [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    cellular amino acid biosynthetic process [TASLink to PubMed article]
    sulfate assimilation [NASLink to PubMed article]
    Molecular Function: sulfite reductase (NADPH) activity [NASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTASDLLTLP QLLAQYSSSA PQNKVFYTTS TKNSHSSFKG LESVATDATH LLNNQDPLNT  60
   61 IKDQLSKDIL TTVFTDETTL VKSIHHLYSL PNKLPLVITV DLNLQDYSAI PALKDLSFPI 120
  121 LISSDLQTAI SNADSSYKIA TSSLTPVFHF LNLEKIGTST AIEQDIDFPT LEIANEETKV 180
  181 ALSEATDSLT NFELVKGKES ITTVIVNLSP YDAEFSSVLP SNVGLIKIRV YRPWNFSKFL 240
  241 EILPSSVTKI AVLQGVSKKS QSNEFQPFLL DFFGNFNELV SRNIEQVVLT NIGNVNDYGN 300
  301 VINTVISNIN KKEPDNNLFL GESNEKAEEQ AEVTQLISSV KKVVNLEDAY IKVLKQLFSS 360
  361 NLQILNQFSS ETIEPSNPEF GFGRFLKQEA QREELISLAK TSLDPSLYLS EDANKIVQLL 420
  421 SKWLSFNGRD LDEAQLQEAN ATGLEIFQLL QSNQDSSTVL KFLKIAPTSD SFIFKSSWLI 480
  481 GSDAWSYDLG HSGIQQVLSS RKNINVLLID SEPYDHRKQN QDRKKDVGLY AMNYYSAYVA 540
  541 SVAVYASYTQ LLTAIIEASK YNGPSIVLAY LPYNSENDTP LEVLKETKNA VESGYWPLYR 600
  601 FNPVYDDPST DKEAFSLDSS VIRKQLQDFL DRENKLTLLT RKDPSLSRNL KQSAGDALTR 660
  661 KQEKRSKAAF DQLLEGLSGP PLHVYYASDG GNAANLAKRL AARASARGLK ATVLSMDDII 720
  721 LEELPGEENV VFITSTAGQG EFPQDGKSFW EALKNDTDLD LASLNVAVFG LGDSEYWPRK 780
  781 EDKHYFNKPS QDLFKRLELL SAKALIPLGL GDDQDADGFQ TAYSEWEPKL WEALGVSGAA 840
  841 VDDEPKPVTN EDIKRESNFL RGTISENLKD TSSGGVTHAN EQLMKFHGIY TQDDRDIREI 900
  901 RKSQGLEPYY MFMARARLPG GKTTPQQWLA LDHLSDTSGN GTLKLTTRAT FQIHGVLKKN 960
  961 LKHTLRGMNA VLMDTLAAAG DVNRNVMVSA LPTNAKVHQQ IADMGKLISD HFLPKTTAYH1020
 1021 EVWLEGPEEQ DDDPSWPSIF ENRKDGPRKK KTLVSGNALV DIEPIYGPTY LPRKFKFNIA1080
 1081 VPPYNDVDVL SIDVGLVAIV NPETQIVEGY NVFVGGGMGT THNNKKTYPR LGSCLGFVKT1140
 1141 EDIIPPLEGI VIVQRDHGDR KDRKHARLKY TVDDMGVEGF KQKVEEYWGK KFEPERPFEF1200
 1201 KSNIDYFGWI KDETGLNHFT AFIENGRVED TPDLPQKTGI RKVAEYMLKT NSGHFRLTGN1260
 1261 QHLVISNITD EHVAGIKSIL KTYKLDNTDF SGLRLSSSSC VGLPTCGLAF AESERFLPDI1320
 1321 ITQLEDCLEE YGLRHDSIIM RMTGCPNGCS RPWLGELALV GKAPHTYNLM LGGGYLGQRL1380
 1381 NKLYKANVKD EEIVDYIKPL FKRYALEREE GEHFGDFCIR VGIIKPTTEG KYFHEDVSED1440
 1441 AY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) MET10 MET5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3829 - low filter Green EM, et al (2005)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MET5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..192] ORFEUS 13.18 E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain
    2 View Details [193..319] ORFEUS 13.18 E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain
    3 View Details [320..679] PSI-BLAST 411.228787 Pyruvate-ferredoxin oxidoreductase, PFOR, domain I; Pyruvate-ferredoxin oxidoreductase, PFOR, domains VI; Pyruvate-ferredoxin oxidoreductase, PFOR, domain II; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; Pyruvate-ferredoxin oxidoreductase, PFOR, domain V
    4 View Details [680..857] PSI-BLAST 191.9691 NADPH-cytochrome p450 reductase, N-terminal domain
    5 View Details [858..1117]
    [1131..1202]    		 PSI-BLAST 1386.0 Sulfite reductase, domains 1 and 3; Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
    6 View Details [1118..1130]
    [1203..1442]    		 PSI-BLAST 1386.0 Sulfite reductase, domains 1 and 3; Sulfite reductase hemoprotein (SiRHP), domains 2 and 4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • acetolactate synthase activity
    		•  2.86666318994863 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  2.75586243560276 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  2.54367237239121 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  2.37626222601658 bayes_pls_golite062009
  • catalytic activity
    		•  2.25537597692103 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.18080419129242 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  1.3936144958597 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.459800433209317 bayes_pls_golite062009
  • transferase activity
    		•  0.413024577830522 bayes_pls_golite062009
  • binding
    		•  0.39163264055064 bayes_pls_golite062009
  • protein binding
    		•  0.149784186812647 bayes_pls_golite062009
    4
    Term Confidence Notes
  • binding
    		•  0.757525096811651 bayes_pls_golite062009
  • protein binding
    		•  0.398609344827318 bayes_pls_golite062009
  • catalytic activity
    		•  0.275631658558537 bayes_pls_golite062009
    5 No functions predicted.
    6
    Term Confidence Notes
  • sulfite reductase (NADPH) activity
    		•  10.5477019483845 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  6.9484358652029 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  6.71341182064697 bayes_pls_golite062009
  • catalytic activity
    		•  1.39967796334655 bayes_pls_golite062009
  • binding
    		•  1.11461228884302 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.08956206944325 bayes_pls_golite062009
  • protein binding
    		•  0.618571973542447 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle