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Protein Overview: VBA4

General Information:
Name(s) found: VBA4 / YDR119W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 768 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole membrane [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKDRQRKK LREFAKLKNR QRNLRKSVQT LKNEVQREAK VPRTSNQIAL GNDKIEEINE  60
   61 NSPLLSAPSK QEEVSIPKAV DIDTIDAQPL HEGPKIDDSP QDEVNSIKGK PADKANEDDL 120
  121 KPPSQHEACG NSALQSSITD FSDRSVSPLQ SITSCNTPMS EHELPVSSSN SFERADDMPV 180
  181 VQADNQTSSS KSLHIVAPSP EVPVSGDEIT SYGYGSIPQS IGDVENGLNP PYVENTSSDE 240
  241 LVHDLTRRRI FSSCMCTYLF FIAMDSSIIL VIASKIASEF HELWRLSLVI SAYLLSNAIG 300
  301 QLVFLKLSLI SSVKLLLCIA QFSFILGGYL SWSSAHFWTF IFARCVTGFG GGSLIALKST 360
  361 IMNRFSQKND SRYSLSASMI TFAMGVVIGP FMMNLFDSSH GSGWRNAFLI PVPFCLVNAS 420
  421 IMLADMYSVK STLYGRPTPT LWKRFKNTLL SPDLYEILTL TLFLLCFVQV TSLDLTGLKN 480
  481 NTMIQALLFS VIIVCGILFF LIETSDTYMN SVISMSLQGD KRLIWTMIGI SFCFAALMCI 540
  541 IPFGTTYFII VLNLSTLQLA ERLSPFFFSI VLGYFSVSYF WKSKGQNFLL KFVLSGATLL 600
  601 LYVALMGVSL NLPVWKQYIC LSLPFLGSSM ILTLLSNLYH EYHEQRKSPI SGSIVYCFGA 660
  661 VGGTVGISLG GYVFHKTLIK LMHEKVMPFS KQGYLKKDLL KIIKHATESS DWVHESAPKF 720
  721 VFQTLIECYL QACRNVFKLS TLFFTITVVA IFIFNRIHCR SQNCLSLS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) VBA4 VPH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 sample: hx3 Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX13 - trans-SNARE complex forms but fusion is blocked. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VBA4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] deduced N/A No confident structure predictions are available.
    2 View Details [75..244] MSA 3.705997 View MSA. No confident structure predictions are available.
    3 View Details [245..427]
    [509..632]    		 PSI-BLAST 7.39794 No description for 1ja5A_ was found.
    4 View Details [428..508] PSI-BLAST 7.39794 No description for 1ja5A_ was found.
    5 View Details [633..768] PSI-BLAST 3.30103 Clc chloride channel

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transporter activity
    		•  1.47137690164233 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.05831640191854 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.04845870423152 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.01835310550526 bayes_pls_golite062009
  • binding
    		•  0.0875556388382674 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle