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Protein Overview: SOR2

General Information:
Name(s) found: SOR2 / YDL246C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Protein of unknown function; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase; computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 357 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: hexose metabolic process [RCALink to PubMed article]
    Molecular Function: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQNSNPAVV LEKVGDIAIE QRPIPTIKDP HYVKLAIKAT GICGSDIHYY RSGGIGKYIL  60
   61 KAPMVLGHES SGQVVEVGDA VTRVKVGDRV AIEPGVPSRY SDETKEGSYN LCPHMAFAAT 120
  121 PPIDGTLVKY YLSPEDFLVK LPEGVSYEEG ACVEPLSVGV HSNKLAGVRF GTKVVVFGAG 180
  181 PVGLLTGAVA RAFGATDVIF VDVFDNKLQR AKDFGATNTF NSSQFSTDKA QDLADGVQKL 240
  241 LGGNHADVVF ECSGADVCID AAVKTTKVGG TMVQVGMGKN YTNFPIAEVS GKEMKLIGCF 300
  301 RYSFGDYRDA VNLVATGKVN VKPLITHKFK FEDAAKAYDY NIAHGGEVVK TIIFGPE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen TEM1 SOR2 2 Uetz P, et al. (2000)
    View Screen PSE1 SOR2 2 Uetz P, et al. (2000)
    View Screen PHO85 SOR2 2 Uetz P, et al. (2000)
    View Screen LOS1 SOR2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154]
    [324..357]    		 PSI-BLAST 851.39794 Ketose reductase (sorbitol dehydrogenase)
    2 View Details [155..323] PSI-BLAST 851.39794 Ketose reductase (sorbitol dehydrogenase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ethanol binding
    		•  4.47659026306883 bayes_pls_golite062009
  • NAD or NADH binding
    		•  4.35058438816264 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  4.1750549780559 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • methylglyoxal reductase (NADH-dependent) activity
    		•  3.00190838171391 bayes_pls_golite062009
  • L-iditol 2-dehydrogenase activity
    		•  3.00103406168296 bayes_pls_golite062009
  • alcohol binding
    		•  2.97042200128883 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  2.94416173750168 bayes_pls_golite062009
  • retinol binding
    		•  2.89007863838685 bayes_pls_golite062009
  • all-trans retinal binding
    		•  2.84803957533249 bayes_pls_golite062009
  • S-(hydroxymethyl)glutathione dehydrogenase activity
    		•  2.58673703881996 bayes_pls_golite062009
  • hydroxymethylfurfural reductase (NADH) activity
    		•  2.2999175117758 bayes_pls_golite062009
  • hydroxymethylfurfural reductase activity
    		•  2.2999175117758 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  2.26153457113968 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  2.16668841986245 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  2.03039843216597 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • DNA binding
    		•  1.61355789916908 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.55390653047158 bayes_pls_golite062009
  • retinoid binding
    		•  1.54383322726845 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.48478425318425 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.42961392805059 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  1.38219425408212 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  1.29842732066898 bayes_pls_golite062009
  • chaperone binding
    		•  1.19079350615542 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  1.07006097264025 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.01627645289834 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • transcription factor activity
    		•  0.91090893050278 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.527946013169731 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.484089941059577 bayes_pls_golite062009
  • kinase activity
    		•  0.461063813999598 bayes_pls_golite062009
  • hydrolase activity
    		•  0.41684292392606 bayes_pls_golite062009
  • hydroxymethylfurfural reductase (NADPH) activity
    		•  0.382131941157781 bayes_pls_golite062009
  • L-arabinitol 2-dehydrogenase activity
    		•  0.382131941157781 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.375415252607746 bayes_pls_golite062009
  • glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity
    		•  0.361275519814065 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • structural molecule activity
    		•  0.345975336806588 bayes_pls_golite062009
  • protein kinase activity
    		•  0.339420053437627 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.320177384202291 bayes_pls_golite062009
  • glyceraldehyde-3-phosphate dehydrogenase activity
    		•  0.298691872199351 bayes_pls_golite062009
  • ATPase activity
    		•  0.275256680720412 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  0.250698007650211 bayes_pls_golite062009
  • methylenetetrahydrofolate dehydrogenase activity
    		•  0.169301675015808 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  0.162625185692811 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  0.0962368786590111 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle