Protein Overview: FRT2

General Information:
Name(s) found:	FRT2 / YAL028W [SGD]
Description(s) found: Found 23 descriptions. SHOW ALL	Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate [SGD]
Organism:	Saccharomyces cerevisiae
Length:	528 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum [IDA]
Biological Process:	response to stress [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNAQIKSSS KGSGIDGTDR NSKDGVEKRP LEDVKQMIDA GTPDVGHKST VETKPNVGWQ  60
   61 ASHSNLAALH EKEQKYEMEH HHARHKLHRQ VIPDYTSAST AMFSDCMFNA APDKVRSLST 120
  121 MKSSGLSPKH PFNVVATFKG PFPQHSVESK PLDGGYSAKD HFPSFKMLQA QQHPAHRHYK 180
  181 DNDKYGLKSP SRSFVKDKKR LVHRFLKSME PSSSGQSKDS SALAPAFDPI LPNVISKPSK 240
  241 RPTHHSHSSD GSSSTQTDIS LQSLLYHDLE SSPKKHVSPS RPPSVASESS PAVANPIGLS 300
  301 PKDACNASFS QSSSSSLSSS SSSSSSTSFS QSVAVDPLEP PGNITYSSSN LSLNSDELDY 360
  361 YQRHIGLQLQ QTEALLKHSL KDEVLKDEND LVKNIANFDK IVKELRDLRS RTIGWKELVE 420
  421 EDYLMNLKQD FDKENPESFE ARLSDTINTN VAKLQDLEKR MASCKDRLAS RKEVMRKMES 480
  481 LLSLENSLMI SKKNVTFASK YRNEALDIVF LIIIIVICYT FKHLVSHK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		AHA1 BUD3 CNS1 CPR6 DIG2 DNM1 DSF1, YNR073C FRT2 GPA2 HOM6 HSC82 HSP104 HSP82 MBB1 MRPL50 PAM1 PPT1 QNS1 RMD8 RTS1 SMT3 STI1 STP4 TDH1 UTP20 YBL104C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GPI14	FRT2	2	Hazbun TR, et al. (2003)
View Screen	EST1	FRT2	2	Uetz P, et al. (2000)
View Screen	YIF1	FRT2	2	Unpublished Fields Lab Data
View Screen	FRT2	YIR014W	2	Unpublished Fields Lab Data
View Screen	SMC5	FRT2	2	Hazbun TR, et al. (2003)
View Screen	FRT2	NBP1	2	Unpublished Fields Lab Data
View Screen	FRT2	STB2	2	Unpublished Fields Lab Data
View Screen	FRT2	FRT1	2	Unpublished Fields Lab Data
View Screen	FRT2	ENA1	2	Unpublished Fields Lab Data
View Screen	FRT2	MNN9	2	Unpublished Fields Lab Data
View Screen	FRT2	FOB1	2	Unpublished Fields Lab Data
View Screen	FRT2	AKR1	2	Unpublished Fields Lab Data
View Screen	SEC17	FRT2	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..528]	deduced	N/A	No confident structure predictions are available.
2	View Details	[243..340]	deduced	N/A	No confident structure predictions are available.
3	View Details	[341..528]	FFAS03	1.09	No description for 2fxmA was found.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2