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Protein Overview: SPAC1006.07

General Information:
Name(s) found: SPAC1006.07 [Sanger Pombe]
Description(s) found:
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  • pir||S71745 translation initiation factor eIF-4A [similarity] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|6318257|emb|CAB60237.1| translation initiation factor eIF4A [Schizosaccharomyces pombe] [NCBI NR]
  • gi|2222814|gb|AAB61679.1| cell cycle control protein eIF-4A [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115766|ref|NP_594854.1| translation initiation factor eIF4A [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|1708418|sp|P47943.2|IF4A_SCHPO RecName: Full=ATP-dependent RNA helicase eIF4A; AltName: Full=Eukaryotic initiation factor 4A; Short=eIF-4A; AltName: Full=Translation initiation factor 1 [NCBI NR]
  • gi|1321961|emb|CAA56772.1| translation initiation factor eIF-4A [Schizosaccharomyces pombe] [NCBI NR]
  • translation initiation factor eIF4A [Sanger Pombe]
  • ATP-dependent RNA helicase eIF4A OS=Schizosaccharomyces pombe GN=tif1 PE=1 SV=2 [Swiss-Prot]
  • EUKARYOTIC INITIATION FACTOR 4A: P78954; [pompepVF.fasta]
  • Eukaryotic initiation factor 4A (eIF4A) (eIF-4A) [pompep4896]
  • |||eukaryotic initiation factor 4a [pompepnew.fasta]
  • |||translation initiation factor|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • eukaryotic initiation factor 4a [Schizosaccharomyces pombe]gi|1321961|emb|CAA56772.1| translation initiation factor eIF-4A [Schizosaccharomyces pombe]gi|6318257|emb|CAB60237.1| tif1 [Schizosaccharomyces pombe]gi|1708418|sp|P47943|IF4A_SCHPO Eukaryotic [nrdb_11152004_Chlamydomonas]
  • (P47943) Eukaryotic initiation factor 4A (eIF4A) (eIF-4A) [pompep4896_normal_reversed]
  • |||translation initiation factor eIF4A|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • translation initiation factor eIF-4A [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • SPAC1006.07 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • cell cycle control protein eIF-4A [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • ATP-dependent RNA helicase eIF4A (Eukaryotic initiation factor 4A) (eIF-4A) (Translation Initiation factor 1) [nr-271106-contam.fasta]
  • hypothetical protein SPAC1006.07 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • |||translation initiation factor eIF4A |Schizosaccharomyces pombe|chr 1|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • ATP-dependent RNA helicase eIF4A OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tif1 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 392 amino acids

    Gene Ontology:
    Cellular Component: eukaryotic translation initiation factor 4F complex [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: positive regulation of translational initiation [ICLink to PubMed article]
    translational initiation [ISSLink to PubMed article]
    Molecular Function: translation initiation factor activity [ISSLink to PubMed article]
    ATP binding [ICLink to PubMed article]
    RNA binding [IEA]
    ATP-dependent RNA helicase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDQLEDSVI ETNYDEVIDT FDDMNLKPEL LRGIYAYGFE RPSAIQQRAI MPILGERDVL  60
   61 AQAQSGTGKT ATFSISVLQK IDTSLKQCQA LILAPTRELA QQIQKVVVAL GDLMNVECHA 120
  121 CIGGTLVRDD MAALQAGVHV VVGTPGRVHD MIQRRALPTD AVQMFVLDEA DEMLSRGFKD 180
  181 QIYDIFQLLP PTAQVVLLSA TMPQDVLEVT TKFMRDPIRI LVKKDELTLE GIKQFYVAVE 240
  241 KEEWKLDTLC DLYETVTVTQ AVIFCNTRRK VDWLTEQLTE RDFTVSSMHG DMDQAQRDTL 300
  301 MHEFRTGSSR ILITTDLLAR GIDVQQVSLV INYDLPANRE NYIHRIGRGG RFGRKGVSIN 360
  361 FVTNDDVRMM REIEQFYNTH IEEMPMNIAD LI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..392] PSI-BLAST 91.154902 No description for 2j0qA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrogen ion transmembrane transporter activity
    		•  9.07129841752891 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  8.58358908736821 bayes_pls_golite062009
  • translation initiation factor activity
    		•  7.79457008386475 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  7.35625288284796 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  6.62734320850541 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  4.98637553020315 bayes_pls_golite062009
  • translation regulator activity
    		•  4.94658029227343 bayes_pls_golite062009
    		• 4.704140727858 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  4.56509805974548 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  4.03326929098701 bayes_pls_golite062009
  • hydrolase activity
    		•  3.63069754092699 bayes_pls_golite062009
  • structural molecule activity
    		•  3.58406348799895 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.4837867129694 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  3.28373827150339 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • motor activity
    		•  2.79327761685782 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.74365461017633 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  2.31476707827367 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.18118655708491 bayes_pls_golite062009
  • RNA cap binding
    		•  2.17871969124431 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.54436515966471 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  1.51134988628578 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.3493704216639 bayes_pls_golite062009
  • protein transporter activity
    		•  1.25342367751911 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  1.23468617030519 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  1.216998547662 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.2155186842031 bayes_pls_golite062009
  • potassium channel activity
    		•  1.20877745413881 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • tubulin binding
    		•  0.979946830272106 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • transcription factor activity
    		•  0.959949409533517 bayes_pls_golite062009
  • cation channel activity
    		•  0.940476916156422 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • microtubule binding
    		•  0.907162506177187 bayes_pls_golite062009
  • actin binding
    		•  0.883285269827407 bayes_pls_golite062009
  • ion channel activity
    		•  0.848261056209476 bayes_pls_golite062009
  • channel activity
    		•  0.806331380134838 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.806331380134838 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.799997700906738 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.72881469450553 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.712344060953362 bayes_pls_golite062009
  • peptidase activity
    		•  0.654073677905812 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.652333406433794 bayes_pls_golite062009
  • gated channel activity
    		•  0.650050847753837 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.607045223341107 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.5886142102548 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.43332053110728 bayes_pls_golite062009
  • snRNA binding
    		•  0.418985924846052 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.347363231484033 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • signal transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.226231702119567 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009
  • signal sequence binding
    		•  6.53725193420218E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle