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Protein Overview: CG11198-PA

General Information:
Name(s) found: CG11198-PA / FBpp0087947 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG11198 (CG11198, FBgn0033246). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3861620..3874729. It has the cytological map location 44A1-44A2. Based on sequence similarity, it is predicted to have molecular function</span>: acetyl-CoA carboxylase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: fatty acid biosynthetic process. 3 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2482 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    Biological Process: fatty acid biosynthetic process [IEA]
    Molecular Function: ATP binding [IEA]
    acetyl-CoA carboxylase activity [ISS]
    biotin binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLITILGTLA AFLAFLLTLI FGRGQKRSKP VQSSAATSAT TATTGDSDNG NTNHNSSVIA  60
   61 ATATATTTSS KPPIAPAAPP SAVKASDKRF PKACIKKVQF SSESLRSDVD ELCDQLKDSA 120
  121 LSNLSNDNIR IACHQNNNNS SINKNQNNNS IDISISISKM SETNESNDTA AQSAEGERPS 180
  181 FLVGDEIDER AAEAGEACDE FPLKMQNDVR QNGDISERRK RLRPSMSRGT GLGQDRHQDR 240
  241 DFHIATTEEF VKRFGGTRVI NKVLIANNGI AAVKCMRSIR RWAYEMFKNE RAIRFVVMVT 300
  301 PEDLKANAEY IKMADHYVPV PGGSNNNNYA NVELIVDIAL RTQVQAVWAG WGHASENPKL 360
  361 PELLHKEGLV FLGPPERAMW ALGDKVASSI VAQTAEIPTL PWSGSDLKAQ YSGKKIKISS 420
  421 ELFARGCVTN VEQGLAAVNK IGFPVMIKAS EGGGGKGIRR VDTTEEFPGL FRQVQAEVPG 480
  481 SPIFVMKLAR GARHLEVQLL ADQYGNAISL FGRDCSIQRR HQKIIEEAPA IVAQPEVFED 540
  541 MEKAAVRLAK MVGYVSAGTV EYLYDPEGRY FFLELNPRLQ VEHPCTEMVA DVNLPAAQLQ 600
  601 IGMGIPLYRL KDIRLLYGES PWGSSVIDFE NPPNKPRPSG HVIAARITSE NPDEGFKPSS 660
  661 GTVQELNFRS SKNVWGYFSV AASGGLHEFA DSQFGHCFSW GENRQQAREN LVIALKELSI 720
  721 RGDFRTTVEY LITLLETNRF LDNSIDTAWL DALIAERVQS EKPDILLGVM CGSLHIADRQ 780
  781 ITESFSSFQT SLEKGQIQAA NTLTNVVDVE LINDGIRYKV QAAKSGANSY FLLMNSSFKE 840
  841 IEVHRLSDGG LLISLEGASY TTYMKEEVDR YRIVIGNQTC VFEKENDPSL LRSPSAGKLI 900
  901 NMIVEDGAHV SKGQAYAEIE VMKMVMTLTS QEAGTVTFVR RPGAVLDAGS LLGHLELDDP 960
  961 SLVTKAQPFK GQFLQPENAP VPEKLNRVHN TYKSILENTL AGYCLPEPFN AQRLRDIIEK1020
 1021 FMQSLRDPSL PLLELQEVIA SISGRIPISV EKKIRKLMTL YERNITSVLA QFPSQQIASV1080
 1081 IDSHAATLQK RADRDVFFLT TQSIVQLVQR YRNGIRGRMK AAVHELLRQY YDVESQFQYG1140
 1141 HYDKCVGLVR EHNKDDMQTV VNTIFSHSQV AKKNLLVTLL IDHLWANEPG LTDELANTLS1200
 1201 ELTSLNRAEH SRVALRSRQV LIAAHQPAYE LRHNQMESIF LSAVDMYGHD FHPENLQRLI1260
 1261 LSETSIFDIL HDFFYHSNRA VCNAALEVYV RRAYTSYELT CLQHLELSGG LPLVHFQFLL1320
 1321 PTAHPNRLFS RMSSPDGLDQ AAAESLGNSF VRTGAIAAFD SFEHFEMYSD EILDLLEDFV1380
 1381 SPAMVNAKVL EAVEAADSIS DSRHSTSINV SLSDPVTRAN AAEEAKSTEP IHIVSVAVRE1440
 1441 TGELDDLQMA QIFGNYCQEH NEELFQRRIR RITFAALKKR QFPKFFTFRA RDKFTEDRIY1500
 1501 RHLEPASAFH LELNRMKTYD LEALPTANQK MHLYLGKAKV SKGQEVTDYR FFIRSIIRHS1560
 1561 DLITKEASFE YLQNEGERVL LEAMDELEVA FSHPHAKRTD CNHIFLNFVP TVIMDPAKIE1620
 1621 ESVTKMIMRY GPRLWKLRVL QAELKMVIRQ SPQSPTQAVR LCIANDSGYF LDISMYTEQT1680
 1681 EPETGIIKFK AYGEKQGSLH GHPISTPYMT KDFLQQKRFQ AQSNGTTYVY DVPDMFRQMT1740
 1741 ERHWREFSKA RPTVDIRTPD KILIECKELV LEGDNLVEMQ RLPGENNCGM VAWRIVLATP1800
 1801 EYPNGREIIV IANDLTYLIG SFGIKEDVLF AKASQLARQL KVPRIYISVN SGARIGLAEE1860
 1861 VKAMFKIAWE DPEEPDKGFK YLYLSTEDYA QVANLNSVRA ILIEDEGEQR YKITDIIGKD1920
 1921 DGLGVENLRY AGLIAGETSQ AYEEIVTIAM VTCRTIGIGS YVVRLGQRVI QIDNSHIILT1980
 1981 GYAALNKLLG RKVYASNNQL GGTQIMFNNG VTHKTEAIDL DGVYTILDWL SYIPAYIGCD2040
 2041 LPIVLPNDRI ERPVDFMPTK SPYDPRWMLG GRVNPVNAND WENGFFDRDS WSEIMASWAK2100
 2101 TVVTGRARLG GVPVGVIAVE TRTVEVEMPA DPANLDSEAK TLQQAGQVWY PDSSYKTAQA2160
 2161 IKDFGREELP LIVFANWRGF SGGMKDMYEQ IVKFGAYIVD GLREYKKPVL IYLPPNAELR2220
 2221 GGAWAVLDSL INPRYMETYA DPEARGGVLE PEGIVEIKYK EKDLVKTIHR LDPTTIALKK2280
 2281 ELDEANASGD KVRAAQVDEK IKARIAVLMH VYHTVAVHFA DLHDTPERML EKECISEIVP2340
 2341 WRDSRRWLYW RLRRLLLEDA YIKKILRAQD NLSVGQAKQM LRRWLVEEKG ATEAYLWDKN2400
 2401 EEMVSWYEEQ INAESIVSRN VNSVRRDAII STISKMLEDC PDVALDAVVG LCQGLTPVNR2460
 2461 GVVVRTLAQM QLNEETSNSN QG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..681] PSI-BLAST 124.0 Carbamoyl phosphate synthetase, large subunit connection domain; Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain; Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains; Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains
    2 View Details [682..814] PSI-BLAST 147.0 No description for 2hjwA was found.
    3 View Details [815..884] deduced N/A No confident structure predictions are available.
    4 View Details [885..956] PSI-BLAST 17.045757 No description for 2dn8A was found.
    5 View Details [957..1083] deduced N/A No confident structure predictions are available.
    6 View Details [1084..1167] PSI-BLAST 12.69897 Dihydrolipoamide succinyltransferase
    7 View Details [1168..1329] MSA 1.075966 View MSA. No confident structure predictions are available.
    8 View Details [1330..1476] deduced N/A No confident structure predictions are available.
    9 View Details [1477..1539] deduced N/A No confident structure predictions are available.
    10 View Details [1540..1654] deduced N/A No confident structure predictions are available.
    11 View Details [1655..2482] PSI-BLAST 1000.0 Acetyl-coenzyme A carboxylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • CoA carboxylase activity
    		•  9.83581323285097 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  9.81059565938621 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  9.76633430002009 bayes_pls_golite062009
  • ligase activity
    		•  7.71401892529536 bayes_pls_golite062009
  • biotin carboxylase activity
    		•  6.9547407447638 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  4.25267317906061 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  4.17451795830682 bayes_pls_golite062009
  • succinate-CoA ligase activity
    		•  3.60521632399322 bayes_pls_golite062009
  • CoA-ligase activity
    		•  3.23896308753196 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  3.04454283840859 bayes_pls_golite062009
  • methylcrotonoyl-CoA carboxylase activity
    		•  2.98357921316004 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  2.73831154716701 bayes_pls_golite062009
  • catalytic activity
    		•  2.5009559386228 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.20282197109991 bayes_pls_golite062009
  • glutathione binding
    		•  1.60917807172757 bayes_pls_golite062009
  • phosphoribosylaminoimidazole carboxylase activity
    		•  1.57708889650281 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  1.55053478055591 bayes_pls_golite062009
  • transporter activity
    		•  1.29381792295125 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  1.11645327303429 bayes_pls_golite062009
  • phosphoribosylamine-glycine ligase activity
    		•  1.04915286326924 bayes_pls_golite062009
  • binding
    		•  0.78342355413916 bayes_pls_golite062009
  • propionyl-CoA carboxylase activity
    		•  0.643677287269589 bayes_pls_golite062009
  • hydrolase activity
    		•  0.543813086594651 bayes_pls_golite062009
  • succinate-CoA ligase (GDP-forming) activity
    		•  0.34559667514727 bayes_pls_golite062009
  • glutathione synthase activity
    		•  0.197350998474496 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.175547438883957 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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