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Protein Overview: MEK1

General Information:
Name(s) found: MEK1 / YOR351C [SGD]
Description(s) found:
Found 34 descriptions.
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  • Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 497 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: protein amino acid phosphorylation [IDALink to PubMed articleLink to PubMed article]
    meiosis [IMPLink to PubMed article]
    Molecular Function: protein serine/threonine kinase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRPLYSCNLA TKDDIEMAGG VAPAHLEVNV GGYNTEQTIP IVKHQLVKVG RNDKECQLVL  60
   61 TNPSISSVHC VFWCVFFDED SIPMFYVKDC SLNGTYLNGL LLKRDKTYLL KHCDVIELSQ 120
  121 GSEENDIKKT RLVFMINDDL QSSLDPKLLD QMGFLREVDQ WEITNRIVGN GTFGHVLITH 180
  181 NSKERDEDVC YHPENYAVKI IKLKPNKFDK EARILLRLDH PNIIKVYHTF CDRNNHLYIF 240
  241 QDLIPGGDLF SYLAKGDCLT SMSETESLLI VFQILQALNY LHDQDIVHRD LKLDNILLCT 300
  301 PEPCTRIVLA DFGIAKDLNS NKERMHTVVG TPEYCAPEVG FRANRKAYQS FSRAATLEQR 360
  361 GYDSKCDLWS LGVITHIMLT GISPFYGDGS ERSIIQNAKI GKLNFKLKQW DIVSDNAKSF 420
  421 VKDLLQTDVV KRLNSKQGLK HIWIAKHLSQ LERLYYKKIL CNNEGPKLES INSDWKRKLP 480
  481 KSVIISQAIP KKKKVLE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ERR3 MEK1 NMD3 RPN1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138] PSI-BLAST 20.39794 Chk2 kinase
    2 View Details [139..246]
    [473..497]    		 PSI-BLAST 475.228787 Calmodulin-dependent protein kinase
    3 View Details [247..472] PSI-BLAST 475.228787 Calmodulin-dependent protein kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  3.5075551075045 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.23926962992034 bayes_pls_golite062009
  • DNA binding
    		•  3.12131448113144 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.91028042727128 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  2.82706319058551 bayes_pls_golite062009
  • protein binding
    		•  2.39508335485646 bayes_pls_golite062009
  • histone binding
    		•  2.27170812041831 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.25132862320271 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  2.10556565012417 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.95921851331594 bayes_pls_golite062009
  • transcription factor activity
    		•  1.89464382469326 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.88096476099716 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.84746485315093 bayes_pls_golite062009
  • kinase activity
    		•  1.82476774968305 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.78280248668052 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.78246425241581 bayes_pls_golite062009
  • protein kinase activity
    		•  1.73373132141588 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.66058356077795 bayes_pls_golite062009
  • SMAD binding
    		•  1.6101563888469 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5642245057124 bayes_pls_golite062009
  • transcription activator activity
    		•  1.53960544319629 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.48483625404671 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  1.3333129315031 bayes_pls_golite062009
  • transferase activity
    		•  1.29860325699399 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.1868962075754 bayes_pls_golite062009
  • promoter binding
    		•  1.15188009117562 bayes_pls_golite062009
  • transcription factor binding
    		•  0.93544177518754 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.9108432673413 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.90981150861416 bayes_pls_golite062009
  • signal transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • R-SMAD binding
    		•  0.70816286022176 bayes_pls_golite062009
  • chromatin binding
    		•  0.62935034847038 bayes_pls_golite062009
  • co-SMAD binding
    		•  0.325865547214071 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.279328480488455 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.161373857796846 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.161373857796846 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.121846363304069 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0504553861724597 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30988141770642 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.22172815474021 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • DNA binding
    		•  1.17130513163489 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.959888295228949 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • transcription factor activity
    		•  0.919430701010326 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • tubulin binding
    		•  0.525721160726465 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • actin binding
    		•  0.456340967230669 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • protein complex binding
    		•  0.343240719858581 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • PTB domain binding
    		•  0.236511077131561 bayes_pls_golite062009
  • microtubule binding
    		•  0.191960933574742 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle