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View Structure Prediction Details

Protein: MEK1
Organism: Saccharomyces cerevisiae
Length: 497 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MEK1.

Description E-value Query
Range		 Subject
Range
MEK1_YEAST - Meiosis-specific serine/threonine-protein kinase MEK1 OS=Saccharomyces cerevisiae (strain ATCC 20450...
MEK1 - Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombin...
gi|190407644 - gi|190407644|gb|EDV10911.1| meiosis-specific serine/threonine protein kinase [Saccharomyces cerevisi...
 0.0 [1..497] [1..497]
gi|20453015 - gi|20453015|gb|AAL68972.1| calmodulin-like-domain protein kinase CPK2 [Cucurbita maxima]
 0.0 [56..493] [5..397]
gi|34147319 - gi|34147319|gb|AAN41657.1| OsCDPK protein [Oryza sativa (japonica cultivar-group)]
 0.0 [127..493] [12..349]
gi|16215467 - gi|16215467|emb|CAC82998.1| calcium-dependent protein kinase 2 [Nicotiana tabacum]
 0.0 [61..493] [12..419]
CDPK1_ARATH - Calcium-dependent protein kinase 1 OS=Arabidopsis thaliana GN=CPK1 PE=1 SV=1
 0.0 [56..493] [5..452]
gi|2315983 - gi|2315983|gb|AAB70706.1| calmodulin-like domain protein kinase [Tortula ruralis]
 0.0 [65..493] [15..414]
gi|15289758 - gi|15289758|dbj|BAB63463.1| calcium dependent protein kinase [Solanum tuberosum]
 0.0 [61..493] [12..416]

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Predicted Domain #1
Region A:
Residues: [1-138] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRPLYSCNLA TKDDIEMAGG VAPAHLEVNV GGYNTEQTIP IVKHQLVKVG RNDKECQLVL  60
   61 TNPSISSVHC VFWCVFFDED SIPMFYVKDC SLNGTYLNGL LLKRDKTYLL KHCDVIELSQ 120
  121 GSEENDIKKT RLVFMIND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.39794
Match: 1gxcA_
Description: Chk2 kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.6561903894619 bayes_pls_golite062009
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity 3.5075551075045 bayes_pls_golite062009
transcription regulator activity 3.23926962992034 bayes_pls_golite062009
DNA binding 3.12131448113144 bayes_pls_golite062009
nucleic acid binding 2.91028042727128 bayes_pls_golite062009
transforming growth factor beta receptor, cytoplasmic mediator activity 2.82706319058551 bayes_pls_golite062009
protein binding 2.39508335485646 bayes_pls_golite062009
histone binding 2.27170812041831 bayes_pls_golite062009
receptor signaling protein activity 2.25132862320271 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase signaling protein activity 2.10556565012417 bayes_pls_golite062009
structure-specific DNA binding 1.95921851331594 bayes_pls_golite062009
transcription factor activity 1.89464382469326 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.88096476099716 bayes_pls_golite062009
double-stranded DNA binding 1.84746485315093 bayes_pls_golite062009
kinase activity 1.82476774968305 bayes_pls_golite062009
sequence-specific DNA binding 1.78280248668052 bayes_pls_golite062009
DNA replication origin binding 1.78246425241581 bayes_pls_golite062009
protein kinase activity 1.73373132141588 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.66058356077795 bayes_pls_golite062009
SMAD binding 1.6101563888469 bayes_pls_golite062009
transcription repressor activity 1.5642245057124 bayes_pls_golite062009
transcription activator activity 1.53960544319629 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.48483625404671 bayes_pls_golite062009
type I transforming growth factor beta receptor binding 1.3333129315031 bayes_pls_golite062009
transferase activity 1.29860325699399 bayes_pls_golite062009
protein serine/threonine kinase activity 1.1868962075754 bayes_pls_golite062009
promoter binding 1.15188009117562 bayes_pls_golite062009
transcription factor binding 0.93544177518754 bayes_pls_golite062009
small conjugating protein ligase activity 0.9108432673413 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.90981150861416 bayes_pls_golite062009
signal transducer activity 0.767071864136971 bayes_pls_golite062009
molecular transducer activity 0.767071864136971 bayes_pls_golite062009
R-SMAD binding 0.70816286022176 bayes_pls_golite062009
chromatin binding 0.62935034847038 bayes_pls_golite062009
co-SMAD binding 0.325865547214071 bayes_pls_golite062009
damaged DNA binding 0.279328480488455 bayes_pls_golite062009
transforming growth factor beta receptor binding 0.161373857796846 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 0.161373857796846 bayes_pls_golite062009
receptor serine/threonine kinase binding 0.121846363304069 bayes_pls_golite062009
protein dimerization activity 0.0504553861724597 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [139-246] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLQSSLDPKL LDQMGFLREV DQWEITNRIV GNGTFGHVLI THNSKERDED VCYHPENYAV  60
   61 KIIKLKPNKF DKEARILLRL DHPNIIKVYH TFCDRNNHLY IFQDLIPG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [473-497] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDWKRKLPKS VIISQAIPKK KKVLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 475.228787
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
transcription regulator activity 1.30988141770642 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
cytoskeletal protein binding 1.22172815474021 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
DNA binding 1.17130513163489 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
transcription repressor activity 0.959888295228949 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
transcription factor activity 0.919430701010326 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
transporter activity 0.595111702412257 bayes_pls_golite062009
tubulin binding 0.525721160726465 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
actin binding 0.456340967230669 bayes_pls_golite062009
transmembrane transporter activity 0.41384976209545 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
protein complex binding 0.343240719858581 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
PTB domain binding 0.236511077131561 bayes_pls_golite062009
microtubule binding 0.191960933574742 bayes_pls_golite062009
substrate-specific transporter activity 0.0922946791401962 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [247-472] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDLFSYLAKG DCLTSMSETE SLLIVFQILQ ALNYLHDQDI VHRDLKLDNI LLCTPEPCTR  60
   61 IVLADFGIAK DLNSNKERMH TVVGTPEYCA PEVGFRANRK AYQSFSRAAT LEQRGYDSKC 120
  121 DLWSLGVITH IMLTGISPFY GDGSERSIIQ NAKIGKLNFK LKQWDIVSDN AKSFVKDLLQ 180
  181 TDVVKRLNSK QGLKHIWIAK HLSQLERLYY KKILCNNEGP KLESIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 475.228787
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle