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Protein Overview: CAC2

General Information:
Name(s) found: CAC2 / YML102W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 468 amino acids

    Gene Ontology:
    Cellular Component: chromatin assembly complex [IDALink to PubMed article]
    chromosome, centromeric region [IDALink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    chromatin silencing [IMPLink to PubMed article]
    nucleosome assembly [IMPLink to PubMed article]
    Molecular Function: transcription regulator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEASHLQIYW HDSQPVYSLT FQKNSANDKL FTAGGDNKVR IWKLNRDENG QNGGVRKIES  60
   61 LDFLGSLTHH EQAINVIRFN SKGDVLASAG DDGQVLLWKQ EDPNTQQESV VRPFGMDAET 120
  121 SEADENKEKW VVWKRLRGGS GATAAAEIYD LAWSPDNRNI VVACMDNSIR LFDVGAGMLV 180
  181 CGQSDHGHYV QGVAWDPLNQ FILSQSADRS LHVYGVILSS AGVVTGLKLR SKIAKAELPC 240
  241 PGDVLRTNYL FHNETLPSFF RRCSISPCGG LVVIPSGVYK VAGDEVANCV YVYTRSGILN 300
  301 SAGGVKNRPA IRIPSLKKPA LMAAFSPVFY ETCQKSVLKL PYKLVFAIAT TNEVLVYDTD 360
  361 VLEPLCVVGN IHYSPITDLA WSEDGSTLLI SSTDGFCSYV SIDTETQFGS RIEPPAMHAE 420
  421 PLDTDESAVA AKNQREAGGI VNMLPVKKIP CNSSDSKKRR IHPTPVDL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CAC2 MSI1 RLF2
    View Details (MIPS) Mewes HW, et al. (2004) CAC2 MSI1 RLF2
    View Details Krogan NJ, et al. (2006) CAC2 FET5 MSI1 RLF2
    View Details Gavin AC, et al. (2006) CAC2 MSI1
    View Details Ho Y, et al. (2002) CAC2 RLF2
    View Details Qiu et al. (2008) CAC2 HIR1 HIR2 HIR3 HPC2 MSI1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RLF2 cac1: TAP-tagged Green EM, et al (2005)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CAC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..48] Pfam 5.0 WD domain, G-beta repeat No confident structure predictions are available.
    2 View Details [49..468] PSI-BLAST 78.491979 Tup1, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  2.79445416141967 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • dynein binding
    		•  1.74989209255308 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19593750149343 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
    		• 0.88172763425403 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • actin binding
    		•  0.529861581509437 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • snoRNA binding
    		•  0.347797037104681 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0936365746095786 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle