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Protein Overview: HIR3

General Information:
Name(s) found: HIR3 / YJR140C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1648 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    HIR complex [IDALink to PubMed article]
    Biological Process: regulation of transcription involved in G1/S-phase of mitotic cell cycle [IMPLink to PubMed article]
    DNA replication-independent nucleosome assembly [IDALink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IGILink to PubMed article]
    Molecular Function: transcription corepressor activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMFNALNSN IEGEQYEAEE HSRELQIEQS FNILQDALID LKNKDFEKSD SKFQELFQID  60
   61 VVKPDRWGMY RNSSPTLDNL RYLCYRNRGM YYHLYLENNY ERLNSQELVN CILKAVENLV 120
  121 ESIQHSDADF AVTDLLARIF KSFNSVKLER LISEYEFTKQ ENLSLLLGRH RKFLLNDLTL 180
  181 MMNNYVELTN KLLVPNLSDN TIFERYHLEK YKDIKPEPLA FGPILSRISE MKKQDEEIMK 240
  241 KLDVFNVTLN EESWDEVAKA LKNLLPSVKT SSLIGRNMDP YNEIEEPIEA VKFELSEAIN 300
  301 NTPSLDRESE RQEEEQDNES VRADDKSGNL APSDIQTNEE ARPNKRTDEH IDSTKPLQRS 360
  361 SKRFKEREQE NSKELVMDVH KRFFGEFNTL LSYIHILPFC DFDTFASKFI IGSSDKQPEK 420
  421 FIPYTDLYEC LKSWSSRYTD IFNQNDYLSS GSNENEELFQ LNALLKSNAF DDKESFPRYL 480
  481 NDLDSDHIRS FISEVNAGNL HFHQVRLKLL FKLLGTYDEG NGRRLIIDYL WESQLLKIVL 540
  541 WFVFGIESNI FALINKNKRQ CKYLALSIYE LLVNHLGNIV EEITNKRIQG HKSADLKSQR 600
  601 NKVEKRIRSW HTLLEQIADE KDKELYVHFQ WTHYCFLQYT CDIVDSRLSE TLTSLENTIK 660
  661 DSDSSLDIAY PNYRHIPALN LNTVQSQKRK IRIIQNITVE DISEDTNSDT HSENHLETLE 720
  721 KVLLHILHPS TNHSNIDEEM VSFIFNSPFL LKIRLWGVLF SSYVKKSSIQ DVQRIYFHVL 780
  781 DFMKGALTSP VYKESNPHGR HQMLLTVLTA IGYLSSQLTA ILNSNRWESS DFVLEDYMFE 840
  841 KLLQTFFFFY TVLFYESSAV NDVSNKSFFK RASKSSGKMK DIMIDLATLI LYYYDLQAKL 900
  901 RTPAEQGIET TELIWSLHTL FGHFHFCDAS NGKFLDLAEK LLCQFINNDS FLQLKQILWC 960
  961 RYHYAIASDN FSPDLHDTKA VEMEKIHSLP LGTYLIKLQY QNKNPYLSSS KTTLKQIMDN1020
 1021 IIEKIGDPST LDNHIISRNS FLLNEYLSRP ITADLLKHTF SGATSLYLTS PNDELQQGMT1080
 1081 AGLFYVSSLQ SLGLYKMRKK SMQARPSELD SIIRMLKNDI IYNTNRFESW ILLGKCYSYI1140
 1141 VEDDLIWTSD KITVPEKKDV IALTQRKAIL CYLMAISIYY SKLDRTIDDK KIILEALDDL1200
 1201 GSMLISGYYN PMNKLCFSWK SSAENTMRLS ETGEVVMEKT KKITTISDFN IEQSIFLCFN1260
 1261 RACSLSGDIK SQDDVFVLNW SSFYNLAKFF FKTDGGNNCK LVAKYITQGC QIAYESSPAK1320
 1321 DPIIEPHYLL VNACYKWVKR GVIGVNEALT LLSKDNQFFQ EQEEFWVNDE GLAWDYQEKF1380
 1381 FFDKIIRLLR HLLSVDKKKW QHRPRYRIAR ILFDDLGDVN GALEEMDSLI SAKSINKNLV1440
 1441 NIWKPDFERP GKHFIYTYQY LVLYLDLLFA IKDFNTTGLV IKKLRRFGSG TVNVNELLER1500
 1501 AINVYTQSAK IKLQLQDKSY VEQILPTLNY QEFLKISEQL NQVFDQGKYP EEISSGLKLA1560
 1561 FQLKKGHSGI AFDSVCLGIY FEYLYFPLAR QDQSLTDVND ENNPALPSSG SVTSKSTPDP1620
 1621 TSKPSAIKKR VTKKEVFDRV RLLVDKIT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ASF1 HIR2 HIR3 RAD53
    View Details Krogan NJ, et al. (2006) ASF1 HIR1 HIR2 HIR3 HPC2 QDR2 SFP1
    View Details Gavin AC, et al. (2006) HIR3 MAM33 RAD53
    View Details Gavin AC, et al. (2002) ASF1 HIR3 MAM33 RAD53 RNR2 RNR4
    View Details Ho Y, et al. (2002) ADH3 CDC10 ECM10 HIR3 MGM101 PYC1 RFA2 SML1
    View Details Qiu et al. (2008) ASF1 CAC2 HIR1 HIR2 HIR3 HPC2 MSI1 RLF2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run HIR2 No Comments Green EM, et al (2005)
    View Run ASF1 sample 3121 run on DecaLCQ: searched for phosphorylation Green EM, et al (2005)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HIR3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..521] deduced N/A No confident structure predictions are available.
    2 View Details [522..1648] MSA 1.003001 View MSA. No confident structure predictions are available.
    3 View Details [498..559] deduced N/A No confident structure predictions are available.
    4 View Details [560..733] deduced N/A No confident structure predictions are available.
    5 View Details [734..909] deduced N/A No confident structure predictions are available.
    6 View Details [910..1027] deduced N/A No confident structure predictions are available.
    7 View Details [1028..1247] deduced N/A No confident structure predictions are available.
    8 View Details [1248..1355] deduced N/A No confident structure predictions are available.
    9 View Details [1356..1648] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.64850159998065 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36976362065221 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.05265117445838 bayes_pls_golite062009
  • DNA binding
    		•  1.96740629247708 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.62975924741087 bayes_pls_golite062009
  • protein binding
    		•  1.51322932625387 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22524361832616 bayes_pls_golite062009
  • transcription factor binding
    		•  0.447234745044969 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.201108481303385 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.0645101607447045 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0514451541233234 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle