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Protein Overview: YHL008C

General Information:
Name(s) found: YHL008C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 627 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    [NOT]monocarboxylic acid transport [IMPLink to PubMed article]
    Molecular Function: transporter activity [ISSLink to PubMed article]
    [NOT]monocarboxylic acid transmembrane transporter activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDDSNYLTP HETALAVVAT AMKKARLQLD TLLINSILGG VLFSSGSFLL VAVYSEDPDI  60
   61 VARNPGIVNL ITGVNFAMGL FYVVMMGADL FNSNILFFSV GVLRKAVTIY DLMISWVVSW 120
  121 LGNIAGSLFV SYLFGHLSGI SSQKLWIIGS RQIIEQKVSY SFVQTFLKGI ACNFFVCLAI 180
  181 YLQLMAKPIH VKFILMSFPI IDFIGIGFTH VVGDMSASFI AMLNGANVSV GKYIWKLLIP 240
  241 ASLGNIVGGL FFSAVVPFYL HLVVVERDRK RLSLPEYEAR DEQPELNMDS RVVRIQKNEC 300
  301 DDDATETGED LENLTEKGFA SIYNTNHDNS SYFTGRSLNS LRSIPSSVIT SDNVTMESDL 360
  361 GEPVQFIPKS NSTTRSPHLG LPHNLPHNHS IKSINRHRIN KRHSLRSPPG VFPVRGMGEP 420
  421 LEREKTIEDA TYDPKENELF LRRAETHNSA YVKNKKKEDD NLLRLVKTEE DREQKEYEKN 480
  481 GGYNILENKP GTRLEKIITH LAENVSSREV TPPILPRTTQ DTFPHNAPAS SPAYTDDAHS 540
  541 LRKANSTTLG GLFRAVSKEF HSSKDAESPD DLLKKMAAVG INRNARITAN NVAGIVNLNK 600
  601 EDLDSTTRRQ KITEPKNFYN RHTSPQL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CPR5 MDH3 PFS1 YDR248C YHL008C YHR097C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CAB4 No Comments Hazbun TR, et al. (2003)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YHL008C Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] PSI-BLAST 53.39794 Aquaporin-1
    2 View Details [151..317] PSI-BLAST 53.39794 Aquaporin-1
    3 View Details [318..627] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • substrate-specific channel activity
    		•  4.290527875436 bayes_pls_golite062009
  • channel activity
    		•  4.28130462644143 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  4.28130462644143 bayes_pls_golite062009
  • transporter activity
    		•  3.97659347318494 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.61874387899829 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.53121060060615 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.25745583133819 bayes_pls_golite062009
  • water transmembrane transporter activity
    		•  2.7217137755064 bayes_pls_golite062009
  • water channel activity
    		•  2.56765170084404 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.3732368130886 bayes_pls_golite062009
  • binding
    		•  0.839813420313223 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.692853799846217 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  0.570477584712317 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  0.357749002379944 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  0.309690615793197 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  0.303822585218745 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle