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Protein Overview: SAN1

General Information:
Name(s) found: SAN1 / YDR143C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Ubiquitin-protein ligase, involved in the proteasome-dependent degradation of aberrant nuclear proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 610 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: chromatin organization [IGILink to PubMed article]
    response to stress [IMPLink to PubMed article]
    ubiquitin-dependent protein catabolic process [IDALink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSESGQEQNR GTNTSPNNAE NNNNSNAASG PLNGGAEQTR NITVSIQYSY FTPERLAHLS  60
   61 NISNNDNNEN NSAASGSTIA NGTGPSFGIG NGGHQPDGAL VLSFRDVPAS TPQDRLNSFI 120
  121 SVAAQLAMER FNRLLNRPKG ISKDEFDKLP VLQVSDLPKA EGPLCSICYD EYEDEVDSTK 180
  181 AKRKRDSENE EESEGTKKRK DNEGAPLRTT ADNDSNPSIT NATVVEPPSI PLTEQQRTLN 240
  241 DEETNPSYKH SPIKLPCGHI FGRECIYKWS RLENSCPLCR QKISESVGVQ RAAQQDTDEV 300
  301 AANEAAFERI RRVLYDPTAV NSTNENSSAP SENTSNTTVP TIGNASSGEQ MLSRTGFFLV 360
  361 PQNGQPLHNP VRLPPNDSDR NGVNGPSSTT QNPPSNSGGS NNNQSPRWVP IPLTLFQFHS 420
  421 PNPNPSASDS SASPSAANGP NSNNTSSDAT DPHHNRLRAV LDHIFNVAQR GTSDTSATTA 480
  481 PGAQTVHNQG RNDSSSSDTT QGSSFLENIS RLTGHFTNGS RDNNNDNNHS NDQQRGGSTG 540
  541 ENNRNNLFSS GVASYRNQNG DVTTVELRNN NSAAFPPTDE NPSQGQGSSS SDTTIHNDVP 600
  601 NDNNEQRSSQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) SAN1 YGR283C YMR310C
    View Details Ho Y, et al. (2002) ACO1 ARP2 BEM4 CDC42 ELG1 GUS1 MCM4 RFC1 RFC2 RFC4 RNQ1 RPA135 SAN1 SRP1 UBI4 YPL113C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    User-submitted Microscopy Data:



      PROTEIN REFERENCE
    View Data SAN1 Gardner, R. G., Nelson, Z. W., and D. E. Gottschling. 2005. Degradation-mediated protein quality control in the nucleus. Cell 120: 803-815.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] MSA 2.147996 View MSA. No confident structure predictions are available.
    2 View Details [136..212] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [213..335] PSI-BLAST 11.69897 Immediate early protein, IEEHV
    4 View Details [336..387] deduced N/A No confident structure predictions are available.
    5 View Details [388..610] MSA 1.055977 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle