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View Structure Prediction Details

Protein: STE6
Organism: Saccharomyces cerevisiae
Length: 1290 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STE6.

Description E-value Query
Range		 Subject
Range
gi|3242460, gi|1... - gi|3242460|dbj|BAA28955.1| multidrug resistance-associated protein (MRP)-like protein-2 (MLP-2) [Rat...
 0.0 [15..1286] [294..1518]
gi|4204793 - gi|4204793|gb|AAD10836.1| P-glycoprotein [Solanum tuberosum]
 0.0 [7..1288] [51..1288]
gi|6671365 - gi|6671365|gb|AAF23176.1|AF216497_1 P-glycoprotein [Gossypium hirsutum]
 0.0 [4..1287] [23..1241]
CE03263 - WBGene00004009 locus:pgp-15 p-glycoprotein (MDR) status:Predicted TR:Q19736 protein_id:CAA91802.1
 0.0 [5..1288] [78..1266]
gi|4102188 - gi|4102188|gb|AAD01430.1| MRP3 [Homo sapiens]
 0.0 [15..1286] [295..1523]
MDR3_MOUSE - Multidrug resistance protein 3 OS=Mus musculus GN=Abcb1a PE=2 SV=2
 0.0 [4..1289] [28..1271]

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Predicted Domain #1
Region A:
Residues: [1-120] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFLSFKTTK HYHIFRYVNI RNDYRLLMIM IIGTVATGLV PAITSILTGR VFDLLSVFVA  60
   61 NGSHQGLYSQ LVQRSMAVMA LGAASVPVMW LSLTSWMHIG ERQGFRIRSQ ILEAYLEEKP 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.84
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lipid transporter activity 6.95325922226092 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 5.4467861893359 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.44654566127945 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.44654566127945 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.43909190876515 bayes_pls_golite062009
primary active transmembrane transporter activity 5.4304944906989 bayes_pls_golite062009
active transmembrane transporter activity 5.38112407181712 bayes_pls_golite062009
ATPase activity, coupled 4.87869064889244 bayes_pls_golite062009
ATPase activity 4.60773943958528 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.38591214726007 bayes_pls_golite062009
pyrophosphatase activity 4.32673473878039 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.31087891816858 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.31037981322306 bayes_pls_golite062009
transporter activity 3.47953169973151 bayes_pls_golite062009
ATP binding 3.44940587603537 bayes_pls_golite062009
adenyl ribonucleotide binding 3.39720556954135 bayes_pls_golite062009
adenyl nucleotide binding 3.3407335909134 bayes_pls_golite062009
hydrolase activity 3.11706952898443 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.96171085039592 bayes_pls_golite062009
ribonucleotide binding 2.94542170749201 bayes_pls_golite062009
purine ribonucleotide binding 2.94377266066642 bayes_pls_golite062009
transmembrane transporter activity 2.94175800357966 bayes_pls_golite062009
substrate-specific transporter activity 2.90743799425416 bayes_pls_golite062009
purine nucleotide binding 2.89330081076061 bayes_pls_golite062009
nucleotide binding 2.86779390539461 bayes_pls_golite062009
binding 1.37806419883931 bayes_pls_golite062009
carbohydrate transmembrane transporter activity 0.989925244519283 bayes_pls_golite062009
catalytic activity 0.372934161904337 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [121-343] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEWYDNNEKL LGDFTQINRC VEELRSSSAE ASAITFQNLV AICALLGTSF YYSWSLTLII  60
   61 LCSSPIITFF AVVFSRMIHV YSEKENSETS KAAQLLTWSM NAAQLVRLYC TQRLERKKFK 120
  121 EIILNCNTFF IKSCFFVAAN AGILRFLTLT MFVQGFWFGS AMIKKGKLNI NDVITCFHSC 180
  181 IMLGSTLNNT LHQIVVLQKG GVAMEKIMTL LKDGSKRNPL NKT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.84
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [344-639] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAHQFPLDYA TSDLTFANVS FSYPSRPSEA VLKNVSLNFS AGQFTFIVGK SGSGKSTLSN  60
   61 LLLRFYDGYN GSISINGHNI QTIDQKLLIE NITVVEQRCT LFNDTLRKNI LLGSTDSVRN 120
  121 ADCSTNENRH LIKDACQMAL LDRFILDLPD GLETLIGTGG VTLSGGQQQR VAIARAFIRD 180
  181 TPILFLDEAV SALDIVHRNL LMKAIRHWRK GKTTIILTHE LSQIESDDYL YLMKEGEVVE 240
  241 SGTQSELLAD PTTTFSTWYH LQNDYSDAKT IVDTETEEKS IHTVESFNSQ LETPKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 198.045757
Match: 1l2tA_
Description: MJ0796
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [640-695] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSCLSNLGYD ETDQLSFYEA IYQKRSNVRT RRVKVEEENI GYALKQQKNT ESSTGP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
lipid transporter activity 7.47642599298853 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 5.57844095962502 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 5.57813579764186 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 5.57813579764186 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 5.5689620139321 bayes_pls_golite062009
primary active transmembrane transporter activity 5.55992639965745 bayes_pls_golite062009
active transmembrane transporter activity 5.50005167063544 bayes_pls_golite062009
ATPase activity, coupled 4.98276715440477 bayes_pls_golite062009
heme transporter activity 4.82479229680991 bayes_pls_golite062009
peptide transporter activity 4.7442815698413 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 4.71935767060308 bayes_pls_golite062009
ATPase activity 4.69795387297193 bayes_pls_golite062009
peptide-transporting ATPase activity 4.63590351019108 bayes_pls_golite062009
nucleoside-triphosphatase activity 4.45923622153365 bayes_pls_golite062009
pyrophosphatase activity 4.39781350157199 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 4.38133275795019 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.38085303582726 bayes_pls_golite062009
cofactor transporter activity 4.34709589308604 bayes_pls_golite062009
oligopeptide-transporting ATPase activity 4.09365342567844 bayes_pls_golite062009
transporter activity 3.71239480053329 bayes_pls_golite062009
ATP binding 3.62300973398915 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
adenyl ribonucleotide binding 3.56796420118589 bayes_pls_golite062009
adenyl nucleotide binding 3.50845581803587 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
phosphate transmembrane-transporting ATPase activity 3.20894563245332 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 3.16975154423199 bayes_pls_golite062009
hydrolase activity 3.14498892233323 bayes_pls_golite062009
transmembrane transporter activity 3.13960906549884 bayes_pls_golite062009
anion transmembrane transporter activity 3.13913638619234 bayes_pls_golite062009
substrate-specific transporter activity 3.1318898376276 bayes_pls_golite062009
ribonucleotide binding 3.09294049852753 bayes_pls_golite062009
purine ribonucleotide binding 3.09132855853944 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
purine nucleotide binding 3.03820055021242 bayes_pls_golite062009
nucleotide binding 3.0109684031543 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.00745742755195 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.9271291809464 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.63419811368692 bayes_pls_golite062009
sterol transporter activity 2.48473697371886 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
canalicular bile acid transmembrane transporter activity 2.33958437214304 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
phosphate transmembrane transporter activity 2.15147988861177 bayes_pls_golite062009
oligopeptide transporter activity 2.05580564974083 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
organic anion transmembrane transporter activity 1.76999970080179 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
potassium channel activity 1.68725597823541 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
sugar transmembrane transporter activity 1.57734504779864 bayes_pls_golite062009
binding 1.40438143932554 bayes_pls_golite062009
phosphonate transmembrane transporter activity 1.40269234722336 bayes_pls_golite062009
carbohydrate-transporting ATPase activity 1.37859980472197 bayes_pls_golite062009
monocarboxylic acid transmembrane transporter activity 1.37836402136387 bayes_pls_golite062009
manganese ion transmembrane transporter activity 1.34412762758893 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
molybdate ion transmembrane transporter activity 1.28313088935613 bayes_pls_golite062009
molybdate transmembrane-transporting ATPase activity 1.28313088935613 bayes_pls_golite062009
carbohydrate-importing ATPase activity 1.27327946933978 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
carbohydrate transmembrane transporter activity 1.21226071573355 bayes_pls_golite062009
sulfate transmembrane-transporting ATPase activity 1.1220946941463 bayes_pls_golite062009
manganese-transporting ATPase activity 1.05250190312265 bayes_pls_golite062009
dipeptide transporter activity 1.01130176523309 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
GTPase activity 0.83849854735032 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
copper ion transmembrane transporter activity 0.798934081014025 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
bile acid transmembrane transporter activity 0.687612064139871 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
cholesterol transporter activity 0.644421039250979 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
vitamin transporter activity 0.477646469354653 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
catalytic activity 0.368034275052766 bayes_pls_golite062009
glucoside transmembrane transporter activity 0.31429820040527 bayes_pls_golite062009
maltose transmembrane transporter activity 0.309333293394255 bayes_pls_golite062009
alpha-glucoside transmembrane transporter activity 0.309333293394255 bayes_pls_golite062009
disaccharide transmembrane transporter activity 0.309333293394255 bayes_pls_golite062009
oligosaccharide transmembrane transporter activity 0.304521826432814 bayes_pls_golite062009
oligosaccharide-transporting ATPase activity 0.304521826432814 bayes_pls_golite062009
maltose-transporting ATPase activity 0.304521826432814 bayes_pls_golite062009
kinase activity 0.300431561463583 bayes_pls_golite062009
neutral amino acid transmembrane transporter activity 0.227570438294493 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.219473333671469 bayes_pls_golite062009
signal recognition particle binding 0.20866768220789 bayes_pls_golite062009
protein kinase activity 0.194459978373898 bayes_pls_golite062009
protein binding 0.193768631623192 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
nucleic acid binding 0.144904409289829 bayes_pls_golite062009
sulfate transmembrane transporter activity 0.104477131120205 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.0689844878028699 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [696-802] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLLSIIQIIK RMIKSIRYKK ILILGLLCSL IAGATNPVFS YTFSFLLEGI VPSTDGKTGS  60
   61 SHYLAKWSLL VLGVAAADGI FNFAKGFLLD CCSEYWVMDL RNEVMEK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [823-1020] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALVLNDLRDL RSLVSEFLSA MTSFVTVSTI GLIWALVSGW KLSLVCISMF PLIIIFSAIY  60
   61 GGILQKCETD YKTSVAQLEN CLYQIVTNIK TIKCLQAEFH FQLTYHDLKI KMQQIASKRA 120
  121 IATGFGISMT NMIVMCIQAI IYYYGLKLVM IHEYTSKEMF TTFTLLLFTI MSCTSLVSQI 180
  181 PDISRGQRAA SWIYRILD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 711.9794
Match: 1jsqA_
Description: MsbA
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [803-822] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTRKNMDWFS GENNKASEIS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1021-1290] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKHNTLEVEN NNARTVGIAG HTYHGKEKKP IVSIQNLTFA YPSAPTAFVY KNMNFDMFCG  60
   61 QTLGIIGESG TGKSTLVLLL TKLYNCEVGK IKIDGTDVND WNLTSLRKEI SVVEQKPLLF 120
  121 NGTIRDNLTY GLQDEILEIE MYDALKYVGI HDFVISSPQG LDTRIDTTLL SGGQAQRLCI 180
  181 ARALLRKSKI LILDECTSAL DSVSSSIINE IVKKGPPALL TMVITHSEQM MRSCNSIAVL 240
  241 KDGKVVERGN FDTLYNNRGE LFQIVSNQSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 711.9794
Match: 1jsqA_
Description: MsbA
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle