YRC Public Data Repository - Protein Structure Prediction

Protein:	NTG1
Organism:	Saccharomyces cerevisiae
Length:	399 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTG1.

Description	E-value	Query Range	Subject Range
NTH1_YEAST - Endonuclease III homolog 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NTG1 PE=1 SV=... NTG1 - DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in bot... gi\|207347995 - gi\|207347995\|gb\|EDZ73989.1\| YAL015Cp-like protein [Saccharomyces cerevisiae AWRI1631]	0.0	[1..399]	[1..399]
gi\|17380754, gi\|... - gi\|20259623\|gb\|AAM14168.1\| putative endonuclease [Arabidopsis thaliana], gi\|17380754\|gb\|AAL36207.1\| ...	4.0E-77	[8..337]	[60..361]
gi\|229903773, gi... - gi\|229903773\|ref\|ZP_04518886.1\| adenine DNA glycosylase [Yersinia pestis Nepal516], gi\|229679543\|gb\|... gi\|15979021, gi\|... - gi\|218928123\|ref\|YP_002345998.1\| adenine DNA glycosylase [Yersinia pestis CO92], gi\|16121255\|ref\|NP_... gi\|25292160 - pir\|\|AH0116 A/G-specific adenine glycosylase (EC 3.2.2.-) [imported] - Yersinia pestis (strain CO92) gi\|149290654, gi... - gi\|149367040\|ref\|ZP_01889073.1\| A/G-specific adenine glycosylase [Yersinia pestis CA88-4125], gi\|149... gi\|229837648, gi... - gi\|229837648\|ref\|ZP_04457810.1\| adenine DNA glycosylase [Yersinia pestis Pestoides A], gi\|229704336\|... gi\|229842567, gi... - gi\|229842567\|ref\|ZP_04462722.1\| adenine DNA glycosylase [Yersinia pestis biovar Orientalis str. Indi... gi\|229697238, gi... - gi\|229840872\|ref\|ZP_04461031.1\| adenine DNA glycosylase [Yersinia pestis biovar Orientalis str. PEXU...	7.0E-64	[102..384]	[2..247]
MUTY_ECOLI - A/G-specific adenine glycosylase (EC 3.2.2.-) - Escherichia coli EG10627 - adenine DNA glycosylase / Adenine DNA glycosylase, G-A mismatched DNA repair; 2-hydroxyadenine glyco... gi\|89109738, gi\|... - gi\|89109738\|ref\|AP_003518.1\| adenine DNA glycosylase [Escherichia coli str. K-12 substr. W3110], gi\|... gi\|169753726, gi... - gi\|170018798\|ref\|YP_001723752.1\| adenine DNA glycosylase [Escherichia coli ATCC 8739], gi\|169753726\|... gi\|75515259 - gi\|75515259\|ref\|ZP_00737443.1\| COG1194: A/G-specific DNA glycosylase [Escherichia coli 53638] gi\|169890348, gi... - gi\|170082513\|ref\|YP_001731833.1\| adenine DNA glycosylase [Escherichia coli str. K-12 substr. DH10B],... gi\|75196910 - gi\|75196910\|ref\|ZP_00706980.1\| COG1194: A/G-specific DNA glycosylase [Escherichia coli HS] EG10627 - adenine DNA glycosylase / Adenine DNA glycosylase, G-A mismatched DNA repair; 2-hydroxyadenine glyco... gi\|124526139, gi... - gi\|124526139\|ref\|ZP_01698144.1\| A/G-specific adenine glycosylase [Escherichia coli B], gi\|124502243\|... gi\|238859929, gi... - gi\|238902083\|ref\|YP_002927879.1\| adenine DNA glycosylase [Escherichia coli BW2952], gi\|238859929\|gb\|... gi\|242378487, gi... - gi\|251786214\|ref\|YP_003000518.1\| hypothetical protein B21_02754 [Escherichia coli BL21], gi\|24237848... gi\|254289631, gi... - gi\|254289631\|ref\|YP_003055379.1\| adenine DNA glycosylase [Escherichia coli BL21(DE3)], gi\|253978938\|... gi\|253974772, gi... - gi\|254162871\|ref\|YP_003045979.1\| adenine DNA glycosylase [Escherichia coli B str. REL606], gi\|253974...	8.0E-64	[106..383]	[6..246]
gi\|213609558 - gi\|213609558\|ref\|ZP_03369384.1\| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar... gi\|213425494 - gi\|213425494\|ref\|ZP_03358244.1\| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar... gi\|214000587 - gi\|214000587\|ref\|ZP_03411322.1\| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar... gi\|213850187 - gi\|213850187\|ref\|ZP_03381085.1\| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar... gi\|213646177 - gi\|213646177\|ref\|ZP_03376230.1\| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar... gi\|16761886 - gi\|16761886\|ref\|NP_457503.1\| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar Ty... gi\|25292161, gi\|... - gi\|25292161\|pir\|\|AG0879 A/G-specific adenine glycosylase STY3265 [imported] - Salmonella enterica su... gi\|29143373, gi\|... - gi\|29143373\|ref\|NP_806715.1\| adenine DNA glycosylase [Salmonella enterica subsp. enterica serovar Ty...	3.0E-63	[106..383]	[6..246]
MUTY_SALTY - A/G-specific adenine glycosylase OS=Salmonella typhimurium GN=mutY PE=3 SV=1 MUTY_SALTY - Adenine DNA glycosylase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=mutY PE=3... MUTY_SALTY - A/G-specific adenine glycosylase OS=Salmonella typhimurium GN=mutY PE=3 SV=1 lcl\|NC_016856.1_... - [gene=mutY] [protein=adenine DNA glycosylase] [protein_id=YP_005239257.1] [location=3287807..3288859... gi\|167990362, gi... - gi\|205331157\|gb\|EDZ17921.1\| A/G-specific adenine glycosylase [Salmonella enterica subsp. enterica se... gi\|198243866, gi... - gi\|198243866\|ref\|YP_002217085.1\| A/G-specific adenine glycosylase [Salmonella enterica subsp. enteri...	5.0E-63	[106..383]	[6..246]

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Predicted Domain #1

Region A:
Residues: [1-119]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKISKYSSM AILRKRPLVK TETGPESELL PEKRTKIKQE EVVPQPVDID WVKSLPNKQY  60
   61 FEWIVVRNGN VPNRWATPLD PSILVTPAST KVPYKFQETY ARMRVLRSKI LAPVDIIGG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [120-132]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSIPVTVASK CGI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [245-399]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AYLTLQKAWG KIEGICVDVH VDRLTKLWKW VDAQKCKTPD QTRTQLQNWL PKGLWTEING  60
   61 LLVGFGQIIT KSRNLGDMLQ FLPPDDPRSS LDWDLQSQLY KEIQQNIMSY PKWVKYLEGK 120
  121 RELNVEAEIN VKHEEKTVEE TMVKLENDIS VKVED

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	128.751666
Match:	2abk__
Description:	Endonuclease III
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.8124964619976	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	4.26870112679392	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	3.71152530486175	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	2.49872706126491	bayes_pls_golite062009
hydrolase activity	2.39042189031819	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.24777884454113	bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	2.21048599823382	bayes_pls_golite062009
catalytic activity	2.13345932727422	bayes_pls_golite062009
alkylbase DNA N-glycosylase activity	1.5832578018127	bayes_pls_golite062009
DNA binding	1.44394874535958	bayes_pls_golite062009
nucleic acid binding	1.36800347239439	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	1.32985950765371	bayes_pls_golite062009
damaged DNA binding	1.32391480975295	bayes_pls_golite062009
binding	1.15752946565805	bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity	1.06383943982125	bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity	0.889914753262716	bayes_pls_golite062009
uracil DNA N-glycosylase activity	0.879508131574476	bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity	0.68578837518217	bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity	0.661651574677137	bayes_pls_golite062009
transcription regulator activity	0.493252955870142	bayes_pls_golite062009
structure-specific DNA binding	0.32094102946624	bayes_pls_golite062009
protein binding	0.0921713980805489	bayes_pls_golite062009
carbon-oxygen lyase activity	0.0676784802238829	bayes_pls_golite062009
double-stranded DNA binding	0.0420287478494503	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [133-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKEQISPRDY RLQVLLGVML SSQTKDEVTA MAMLNIMRYC IDELHSEEGM TLEAVLQINE  60
   61 TKLDELIHSV GFHTRKAKYI LSTCKILQDQ FSSDVPATIN ELLGLPGVGP KM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	128.751666
Match:	2abk__
Description:	Endonuclease III
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: