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Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: DNA-3-methyladenine glycosylase I activity
Acc: GO:0008725
Aspect: Molecular Function
Desc: Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
Synonyms:
  • DNA glycosidase I activity
  • deoxyribonucleate 3-methyladenine glycosidase I
  • alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
  • DNA-3-methyladenine glycosidase I activity
  • 3-methyladenine DNA glycosylase I
Proteins in PDR annotated with:
   This term: 14 [Search]
   Term or descendants: 14 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008725 - DNA-3-methyladenine glycosylase I activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle