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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rim11. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 22 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC25
  • cytoplasm
  • plasma membrane
  • traversing start control point of mitotic cell cycle
  • Ras protein signal transduction
  • replicative cell aging
  • Ras guanyl-nucleotide exchange factor activity
  • CKI1
  • cytosol
  • phosphatidylcholine biosynthetic process
  • choline kinase activity
  • GCR2
  • nucleus
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of glycolysis
  • transcription activator activity
  • GIN4
  • cellular bud neck
  • axial cellular bud site selection
  • septin ring assembly
  • protein amino acid phosphorylation
  • budding cell bud growth
  • septin checkpoint
  • protein kinase activity
  • HOM3
  • cytoplasm
  • response to drug
  • methionine metabolic process
  • threonine metabolic process
  • homoserine biosynthetic process
  • aspartate kinase activity
  • IRA1
  • mitochondrion
  • membrane
  • negative regulation of Ras protein signal transduction
  • regulation of adenylate cyclase activity
  • negative regulation of cAMP biosynthetic process
  • positive regulation of Ras GTPase activity
  • Ras GTPase activator activity
  • IRA2
  • cytoplasm
  • mitochondrion
  • negative regulation of Ras protein signal transduction
  • negative regulation of cAMP biosynthetic process
  • positive regulation of Ras GTPase activity
  • response to stress
  • Ras GTPase activator activity
  • MYO2
  • incipient cellular bud site
  • cellular bud tip
  • cellular bud neck
  • fungal-type vacuole membrane
  • myosin V complex
  • mating projection tip
  • vesicle
  • filamentous actin
  • mitochondrion inheritance
  • vacuole inheritance
  • establishment of mitotic spindle orientation
  • unidimensional cell growth
  • vesicle-mediated transport
  • Golgi inheritance
  • vesicle transport along actin filament
  • peroxisome inheritance
  • membrane addition at site of cytokinesis
  • budding cell apical bud growth
  • actin filament binding
  • calmodulin binding
  • microfilament motor activity
  • MYO4
  • cellular bud
  • mitochondrion
  • myosin V complex
  • filamentous actin
  • intracellular mRNA localization
  • endoplasmic reticulum inheritance
  • gene conversion at mating-type locus
  • actin filament binding
  • microfilament motor activity
  • NAP1
  • nucleus
  • cytoplasm
  • nuclear nucleosome
  • M phase of mitotic cell cycle
  • budding cell bud growth
  • nucleosome assembly
  • histone binding
  • PMD1
  • cytoplasm
  • sporulation resulting in formation of a cellular spore
  • molecular_function
  • PRS2
  • cytoplasm
  • 'de novo' pyrimidine base biosynthetic process
  • tryptophan biosynthetic process
  • 'de novo' IMP biosynthetic process
  • histidine biosynthetic process
  • purine ribonucleoside salvage
  • ribose phosphate diphosphokinase activity
  • PRS3
  • cytoplasm
  • 'de novo' pyrimidine base biosynthetic process
  • tryptophan biosynthetic process
  • regulation of cell size
  • 'de novo' IMP biosynthetic process
  • telomere maintenance
  • ribosome biogenesis
  • histidine biosynthetic process
  • purine ribonucleoside salvage
  • ribose phosphate diphosphokinase activity
  • PRS5
  • cytoplasm
  • 'de novo' pyrimidine base biosynthetic process
  • tryptophan biosynthetic process
  • 'de novo' IMP biosynthetic process
  • telomere maintenance
  • histidine biosynthetic process
  • purine ribonucleoside salvage
  • ribose phosphate diphosphokinase activity
  • RIM11
  • cytoplasm
  • ascospore formation
  • proteolysis
  • protein amino acid phosphorylation
  • response to stress
  • protein serine/threonine kinase activity
  • glycogen synthase kinase 3 activity
  • TPS1
  • cytoplasm
  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
  • carbohydrate metabolic process
  • response to drug
  • trehalose biosynthetic process
  • response to stress
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
  • TSL1
  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
  • trehalose biosynthetic process
  • response to stress
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
  • trehalose-phosphatase activity
  • enzyme regulator activity
  • YDR170W-A
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • RNA binding
  • protein binding
  • YER138C
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • DNA-directed DNA polymerase activity
  • RNA-directed DNA polymerase activity
  • RNA binding
  • protein binding
  • ribonuclease activity
  • peptidase activity
  • YER160C
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • DNA-directed DNA polymerase activity
  • RNA-directed DNA polymerase activity
  • RNA binding
  • protein binding
  • ribonuclease activity
  • peptidase activity
  • YJR027W
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • DNA-directed DNA polymerase activity
  • RNA-directed DNA polymerase activity
  • RNA binding
  • protein binding
  • ribonuclease activity
  • peptidase activity
  • YJR028W
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • RNA binding
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    myosin V complex 1.1672E-5 22 2 2 6292
    filamentous actin 1.1672E-5 22 2 2 6292
    unconventional myosin complex 1.1672E-5 22 2 2 6292
    myosin complex 3.4941E-5 22 3 2 6292
    alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) 6.9734E-5 22 4 2 6292
    retrotransposon nucleocapsid 7.1795E-5 22 131 5 6292
    actin filament 4.1399E-4 22 9 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleoside monophosphate biosynthetic process 2.4655E-8 22 27 5 6292
    nucleoside monophosphate metabolic process 6.081E-8 22 32 5 6292
    purine nucleotide biosynthetic process 5.5411E-7 22 49 5 6292
    purine ribonucleotide metabolic process 7.5011E-7 22 52 5 6292
    ribonucleotide metabolic process 9.9724E-7 22 55 5 6292
    purine ribonucleoside salvage 1.2872E-6 22 7 3 6292
    purine nucleoside biosynthetic process 1.2872E-6 22 7 3 6292
    ribonucleoside biosynthetic process 1.2872E-6 22 7 3 6292
    nucleoside biosynthetic process 1.2872E-6 22 7 3 6292
    purine ribonucleoside biosynthetic process 1.2872E-6 22 7 3 6292
    nucleoside salvage 1.2872E-6 22 7 3 6292
    purine nucleotide metabolic process 1.3046E-6 22 58 5 6292
    nucleotide biosynthetic process 3.3536E-6 22 70 5 6292
    purine salvage 4.3833E-6 22 10 3 6292
    cellular biogenic amine metabolic process 6.8651E-6 22 37 4 6292
    tryptophan biosynthetic process 7.9996E-6 22 12 3 6292
    tryptophan metabolic process 7.9996E-6 22 12 3 6292
    indole and derivative metabolic process 7.9996E-6 22 12 3 6292
    indole derivative metabolic process 7.9996E-6 22 12 3 6292
    indole derivative biosynthetic process 7.9996E-6 22 12 3 6292
    indolalkylamine metabolic process 7.9996E-6 22 12 3 6292
    indolalkylamine biosynthetic process 7.9996E-6 22 12 3 6292
    'de novo' pyrimidine base biosynthetic process 1.0376E-5 22 13 3 6292
    nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 1.1638E-5 22 90 5 6292
    nucleobase, nucleoside and nucleotide biosynthetic process 1.1638E-5 22 90 5 6292
    negative regulation of cAMP biosynthetic process 1.1672E-5 22 2 2 6292
    negative regulation of cAMP metabolic process 1.1672E-5 22 2 2 6292
    negative regulation of nucleotide biosynthetic process 1.1672E-5 22 2 2 6292
    negative regulation of cyclic nucleotide metabolic process 1.1672E-5 22 2 2 6292
    negative regulation of cyclic nucleotide biosynthetic process 1.1672E-5 22 2 2 6292
    positive regulation of Ras GTPase activity 1.1672E-5 22 2 2 6292
    regulation of Ras GTPase activity 1.1672E-5 22 2 2 6292
    positive regulation of GTPase activity 1.1672E-5 22 2 2 6292
    negative regulation of nucleotide metabolic process 1.1672E-5 22 2 2 6292
    purine ribonucleoside metabolic process 1.6433E-5 22 15 3 6292
    histidine metabolic process 2.0179E-5 22 16 3 6292
    pyrimidine base biosynthetic process 2.0179E-5 22 16 3 6292
    purine nucleoside metabolic process 2.0179E-5 22 16 3 6292
    'de novo' IMP biosynthetic process 2.0179E-5 22 16 3 6292
    histidine biosynthetic process 2.0179E-5 22 16 3 6292
    histidine family amino acid metabolic process 2.0179E-5 22 16 3 6292
    histidine family amino acid biosynthetic process 2.0179E-5 22 16 3 6292
    IMP metabolic process 2.4447E-5 22 17 3 6292
    IMP biosynthetic process 2.4447E-5 22 17 3 6292
    pyrimidine base metabolic process 2.927E-5 22 18 3 6292
    aromatic amino acid family biosynthetic process 2.927E-5 22 18 3 6292
    chorismate metabolic process 2.927E-5 22 18 3 6292
    ribonucleoside metabolic process 3.468E-5 22 19 3 6292
    purine ribonucleoside monophosphate biosynthetic process 3.468E-5 22 19 3 6292
    positive regulation of hydrolase activity 3.4941E-5 22 3 2 6292
    cellular biogenic amine biosynthetic process 4.0707E-5 22 20 3 6292
    regulation of cellular catabolic process 4.0707E-5 22 20 3 6292
    purine nucleoside monophosphate biosynthetic process 4.0707E-5 22 20 3 6292
    ribonucleoside monophosphate biosynthetic process 4.0707E-5 22 20 3 6292
    cellular amino acid derivative metabolic process 5.1336E-5 22 61 4 6292
    cellular metabolic compound salvage 5.4742E-5 22 22 3 6292
    nucleobase biosynthetic process 6.2811E-5 22 23 3 6292
    nucleoside phosphate metabolic process 6.4263E-5 22 128 5 6292
    nucleotide metabolic process 6.4263E-5 22 128 5 6292
    regulation of cAMP metabolic process 6.9734E-5 22 4 2 6292
    regulation of cAMP biosynthetic process 6.9734E-5 22 4 2 6292
    regulation of nucleotide biosynthetic process 6.9734E-5 22 4 2 6292
    regulation of cyclic nucleotide biosynthetic process 6.9734E-5 22 4 2 6292
    cAMP metabolic process 6.9734E-5 22 4 2 6292
    regulation of cyclic nucleotide metabolic process 6.9734E-5 22 4 2 6292
    cAMP biosynthetic process 6.9734E-5 22 4 2 6292
    cyclic nucleotide biosynthetic process 6.9734E-5 22 4 2 6292
    cyclic nucleotide metabolic process 6.9734E-5 22 4 2 6292
    regulation of catabolic process 7.1621E-5 22 24 3 6292
    purine ribonucleoside monophosphate metabolic process 7.1621E-5 22 24 3 6292
    aromatic amino acid family metabolic process 7.1621E-5 22 24 3 6292
    transposition, RNA-mediated 7.7185E-5 22 133 5 6292
    purine nucleoside monophosphate metabolic process 8.1203E-5 22 25 3 6292
    ribonucleoside monophosphate metabolic process 8.1203E-5 22 25 3 6292
    nucleoside metabolic process 9.1587E-5 22 26 3 6292
    transposition 1.0194E-4 22 141 5 6292
    cellular amino acid derivative biosynthetic process 1.1488E-4 22 28 3 6292
    regulation of nucleotide catabolic process 1.1598E-4 22 5 2 6292
    ribonucleoside triphosphate catabolic process 1.1598E-4 22 5 2 6292
    purine ribonucleoside triphosphate catabolic process 1.1598E-4 22 5 2 6292
    GTP catabolic process 1.1598E-4 22 5 2 6292
    purine nucleotide catabolic process 1.1598E-4 22 5 2 6292
    purine ribonucleotide catabolic process 1.1598E-4 22 5 2 6292
    regulation of GTPase activity 1.1598E-4 22 5 2 6292
    regulation of GTP catabolic process 1.1598E-4 22 5 2 6292
    regulation of purine nucleotide catabolic process 1.1598E-4 22 5 2 6292
    ribonucleotide catabolic process 1.1598E-4 22 5 2 6292
    purine nucleoside triphosphate catabolic process 1.1598E-4 22 5 2 6292
    dicarboxylic acid metabolic process 1.4173E-4 22 30 3 6292
    cellular nitrogen compound biosynthetic process 1.5121E-4 22 247 6 6292
    nucleobase, nucleoside and nucleotide metabolic process 1.6948E-4 22 157 5 6292
    trehalose biosynthetic process 1.736E-4 22 6 2 6292
    glycoside biosynthetic process 1.736E-4 22 6 2 6292
    negative regulation of cell communication 1.736E-4 22 6 2 6292
    negative regulation of small GTPase mediated signal transduction 1.736E-4 22 6 2 6292
    regulation of small GTPase mediated signal transduction 1.736E-4 22 6 2 6292
    regulation of Ras protein signal transduction 1.736E-4 22 6 2 6292
    negative regulation of Ras protein signal transduction 1.736E-4 22 6 2 6292
    disaccharide biosynthetic process 1.736E-4 22 6 2 6292
    negative regulation of signaling pathway 1.736E-4 22 6 2 6292
    nucleobase metabolic process 1.8917E-4 22 33 3 6292
    budding cell bud growth 2.07E-4 22 34 3 6292
    GTP metabolic process 2.4252E-4 22 7 2 6292
    regulation of nucleotide metabolic process 2.4252E-4 22 7 2 6292
    nucleoside triphosphate catabolic process 2.4252E-4 22 7 2 6292
    heterocycle metabolic process 2.5296E-4 22 171 5 6292
    nucleotide catabolic process 3.2267E-4 22 8 2 6292
    aromatic compound biosynthetic process 3.3716E-4 22 40 3 6292
    Ras protein signal transduction 3.6295E-4 22 41 3 6292
    purine ribonucleotide biosynthetic process 3.8999E-4 22 42 3 6292
    trehalose metabolic process 4.1399E-4 22 9 2 6292
    regulation of hydrolase activity 4.1399E-4 22 9 2 6292
    cellular process 4.2871E-4 22 4426 22 6292
    ribonucleotide biosynthetic process 4.7878E-4 22 45 3 6292
    glycoside metabolic process 5.1639E-4 22 10 2 6292
    small molecule biosynthetic process 5.1972E-4 22 310 6 6292
    cellular amino acid biosynthetic process 5.8112E-4 22 114 4 6292
    developmental process 7.3693E-4 22 331 6 6292
    amine biosynthetic process 7.5097E-4 22 122 4 6292
    reproduction of a single-celled organism 7.5892E-4 22 217 5 6292
    cellular amine metabolic process 8.4169E-4 22 222 5 6292
    disaccharide metabolic process 8.894E-4 22 13 2 6292
    regulation of cell communication 1.0354E-3 22 14 2 6292
    nucleobase, nucleoside, nucleotide and nucleic acid catabolic process 1.1922E-3 22 15 2 6292
    nucleobase, nucleoside and nucleotide catabolic process 1.1922E-3 22 15 2 6292
    carboxylic acid biosynthetic process 1.2244E-3 22 139 4 6292
    organic acid biosynthetic process 1.2244E-3 22 139 4 6292
    cellular amino acid and derivative metabolic process 1.2655E-3 22 243 5 6292
    amine metabolic process 1.2655E-3 22 243 5 6292
    small GTPase mediated signal transduction 1.3466E-3 22 64 3 6292
    positive regulation of molecular function 1.3596E-3 22 16 2 6292
    oligosaccharide biosynthetic process 1.3596E-3 22 16 2 6292
    positive regulation of catalytic activity 1.3596E-3 22 16 2 6292
    heterocycle biosynthetic process 1.7453E-3 22 70 3 6292
    cellular developmental process 2.2287E-3 22 276 5 6292
    cellular aromatic compound metabolic process 2.6534E-3 22 81 3 6292
    small molecule metabolic process 2.9513E-3 22 760 8 6292
    cellular nitrogen compound catabolic process 3.0747E-3 22 24 2 6292
    Golgi inheritance 3.4965E-3 22 1 1 6292
    asexual reproduction 3.5799E-3 22 90 3 6292
    cell budding 3.5799E-3 22 90 3 6292
    heterocycle catabolic process 3.6053E-3 22 26 2 6292
    purine ribonucleoside triphosphate metabolic process 3.8855E-3 22 27 2 6292
    purine nucleoside triphosphate metabolic process 3.8855E-3 22 27 2 6292
    oligosaccharide metabolic process 4.1755E-3 22 28 2 6292
    regulation of signaling pathway 4.1755E-3 22 28 2 6292
    ribonucleoside triphosphate metabolic process 4.4753E-3 22 29 2 6292
    cellular amino acid metabolic process 4.5389E-3 22 199 4 6292
    reproduction 4.7147E-3 22 328 5 6292
    nucleoside triphosphate metabolic process 6.1189E-3 22 34 2 6292
    developmental growth involved in morphogenesis 6.9813E-3 22 2 1 6292
    developmental growth 6.9813E-3 22 2 1 6292
    unidimensional cell growth 6.9813E-3 22 2 1 6292
    membrane addition at site of cytokinesis 6.9813E-3 22 2 1 6292
    vesicle transport along actin filament 6.9813E-3 22 2 1 6292
    actin filament-based movement 6.9813E-3 22 2 1 6292
    endoplasmic reticulum inheritance 6.9813E-3 22 2 1 6292
    intracellular signal transduction 7.1103E-3 22 115 3 6292
    small molecule catabolic process 8.9459E-3 22 125 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transferase activity, transferring phosphorus-containing groups 4.9368E-7 22 420 10 6292
    ribose phosphate diphosphokinase activity 7.372E-7 22 6 3 6292
    transferase activity 3.0225E-6 22 797 12 6292
    diphosphotransferase activity 3.0753E-6 22 9 3 6292
    alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 3.4941E-5 22 3 2 6292
    microfilament motor activity 1.1598E-4 22 5 2 6292
    protein binding 7.1052E-4 22 612 8 6292
    actin filament binding 7.5417E-4 22 12 2 6292
    UDP-glucosyltransferase activity 1.0354E-3 22 14 2 6292
    small GTPase regulator activity 1.0626E-3 22 59 3 6292
    glucosyltransferase activity 1.3596E-3 22 16 2 6292
    motor activity 1.7262E-3 22 18 2 6292
    Ras GTPase activator activity 2.1346E-3 22 20 2 6292
    actin binding 2.3543E-3 22 21 2 6292
    GTPase regulator activity 2.9432E-3 22 84 3 6292
    aspartate kinase activity 3.4965E-3 22 1 1 6292
    calmodulin binding 3.4965E-3 22 1 1 6292
    UDP-glycosyltransferase activity 3.8855E-3 22 27 2 6292
    nucleoside-triphosphatase regulator activity 4.1704E-3 22 95 3 6292
    catalytic activity 4.4516E-3 22 2150 14 6292
    RNA-directed DNA polymerase activity 4.6833E-3 22 99 3 6292
    enzyme regulator activity 5.2231E-3 22 207 4 6292
    GTPase activator activity 5.4328E-3 22 32 2 6292
    DNA-directed DNA polymerase activity 6.2857E-3 22 110 3 6292
    kinase activity 6.6879E-3 22 222 4 6292
    choline kinase activity 6.9813E-3 22 2 1 6292
    DNA polymerase activity 7.1103E-3 22 115 3 6292
    RNA binding 7.5822E-3 22 367 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle