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Protein Overview: PRS2

General Information:
Name(s) found: PRS2 / YER099C [SGD]
Description(s) found:
Found 35 descriptions.
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  • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 318 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: 'de novo' pyrimidine base biosynthetic process [TASLink to PubMed article]
    tryptophan biosynthetic process [TASLink to PubMed article]
    'de novo' IMP biosynthetic process [TASLink to PubMed article]
    histidine biosynthetic process [TASLink to PubMed article]
    purine ribonucleoside salvage [TASLink to PubMed article]
    Molecular Function: ribose phosphate diphosphokinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTNSIKLLA GNSHPGLAEL ISQRLGVPLS KVGVYQYSNK ETSVTIGESI RDEDVYIIQT  60
   61 GYGEHEINDF LMELLILIHA CKTASVRRIT AVIPNFPYAR QDKKDKSRAP ITAKLIANLL 120
  121 ETAGCDHVIT MDLHASQIQG FFHIPVDNLY GEPSVLNYIR TKTDFNNAIL VSPDAGGAKR 180
  181 VASLADKLDM NFALIHKERQ KANEVSRMLL VGDVAGKSCL LIDDMADTCG TLVKACDTLM 240
  241 DHGAKEVIAI VTHGIFSGSA REKLINSRLS RIVCTNTVPV DLDLDIVDQV DISPTIAEAI 300
  301 RRLHNGESVS YLFTHAPV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CDC25 CKI1 GCR2 GIN4 HOM3 IRA1 IRA2 MYO2 MYO4 NAP1 PMD1 PRS2 PRS3 PRS5 RIM11 TPS1 TSL1 YDR170W-A YER138C YER160C YJR027W YJR028W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PRS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149]
    [293..318]    		 PSI-BLAST 793.383689 Phosphoribosylpyrophosphate synthetase
    2 View Details [150..292] PSI-BLAST 793.383689 Phosphoribosylpyrophosphate synthetase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle