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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Snp1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
COR1
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • DOG1
  • cellular_component
  • glucose metabolic process
  • 2-deoxyglucose-6-phosphatase activity
  • ENP1
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • preribosome, small subunit precursor
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • FET4
  • integral to plasma membrane
  • plasma membrane
  • low-affinity iron ion transport
  • intracellular copper ion transport
  • copper ion import
  • iron ion transmembrane transporter activity
  • copper ion transmembrane transporter activity
  • FPR3
  • nucleolus
  • meiotic recombination checkpoint
  • peptidyl-prolyl cis-trans isomerase activity
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAM33
  • mitochondrial matrix
  • mitochondrion
  • response to drug
  • aerobic respiration
  • molecular_function
  • PIM1
  • mitochondrial matrix
  • mitochondrion
  • response to heat
  • proteolysis
  • ATP-dependent peptidase activity
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • QCR2
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • SAP185
  • cytoplasm
  • mitochondrion
  • G1/S transition of mitotic cell cycle
  • protein serine/threonine phosphatase activity
  • SAP190
  • cytoplasm
  • G1/S transition of mitotic cell cycle
  • protein serine/threonine phosphatase activity
  • SIT4
  • nucleus
  • cytoplasm
  • DNA repair
  • G1/S transition of mitotic cell cycle
  • cellular cell wall organization
  • telomere maintenance
  • intracellular protein kinase cascade
  • protein amino acid phosphorylation
  • replicative cell aging
  • actin cytoskeleton organization
  • protein serine/threonine phosphatase activity
  • SNP1
  • commitment complex
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • U1 snRNA binding
  • mRNA binding
  • SRP1
  • nucleus
  • cytoplasm
  • nucleocytoplasmic transport
  • protein transmembrane transporter activity
  • VAC14
  • fungal-type vacuole membrane
  • vacuole
  • vacuole inheritance
  • phospholipid metabolic process
  • enzyme activator activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mitochondrial respiratory chain complex III 2.6962E-4 16 10 2 6292
    respiratory chain complex III 2.6962E-4 16 10 2 6292
    mitochondrial respiratory chain 1.9016E-3 16 26 2 6292
    respiratory chain 1.9016E-3 16 26 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    G1/S transition of mitotic cell cycle 2.459E-4 16 50 3 6292
    aerobic respiration 1.0951E-3 16 83 3 6292
    interphase of mitotic cell cycle 1.7195E-3 16 97 3 6292
    interphase 1.7195E-3 16 97 3 6292
    cellular respiration 1.7195E-3 16 97 3 6292
    low-affinity iron ion transport 2.5429E-3 16 1 1 6292
    meiotic prophase I 5.0798E-3 16 2 1 6292
    prophase 5.0798E-3 16 2 1 6292
    nuclear mRNA 3'-splice site recognition 5.0798E-3 16 2 1 6292
    meiotic cell cycle checkpoint 5.0798E-3 16 2 1 6292
    meiotic recombination checkpoint 5.0798E-3 16 2 1 6292
    energy derivation by oxidation of organic compounds 5.8113E-3 16 149 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein serine/threonine phosphatase activity 3.3857E-5 16 26 3 6292
    phosphatase activity 5.4679E-5 16 87 4 6292
    snRNA binding 6.0363E-5 16 5 2 6292
    phosphoric ester hydrolase activity 1.0201E-4 16 102 4 6292
    phosphoprotein phosphatase activity 1.5652E-4 16 43 3 6292
    oxidoreductase activity, acting on diphenols and related substances as donors 2.1602E-4 16 9 2 6292
    oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor 2.1602E-4 16 9 2 6292
    ubiquinol-cytochrome-c reductase activity 2.1602E-4 16 9 2 6292
    inorganic cation transmembrane transporter activity 1.9314E-3 16 101 3 6292
    U1 snRNA binding 2.5429E-3 16 1 1 6292
    cation transmembrane transporter activity 3.0128E-3 16 118 3 6292
    substrate-specific transmembrane transporter activity 3.8508E-3 16 267 4 6292
    2-deoxyglucose-6-phosphatase activity 5.0798E-3 16 2 1 6292
    U5 snRNA binding 5.0798E-3 16 2 1 6292
    ATP-dependent peptidase activity 5.0798E-3 16 2 1 6292
    ion transmembrane transporter activity 5.4906E-3 16 146 3 6292
    transmembrane transporter activity 6.2704E-3 16 306 4 6292
    hydrogen ion transmembrane transporter activity 8.0328E-3 16 54 2 6292
    substrate-specific transporter activity 8.7141E-3 16 336 4 6292
    hydrolase activity, acting on ester bonds 9.1751E-3 16 341 4 6292
    monovalent inorganic cation transmembrane transporter activity 9.5338E-3 16 59 2 6292

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