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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rpt3. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 24 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • CPR6
  • cytoplasm
  • protein folding
  • peptidyl-prolyl cis-trans isomerase activity
  • unfolded protein binding
  • IDH2
  • mitochondrial matrix
  • mitochondrion
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • LHS1
  • endoplasmic reticulum lumen
  • protein transport
  • response to unfolded protein
  • unfolded protein binding
  • MDN1
  • nucleus
  • mitochondrion
  • nucleoplasm
  • protein complex assembly
  • rRNA processing
  • ribosomal large subunit assembly
  • ATPase activity
  • MKT1
  • polysome
  • cytoplasm
  • interspecies interaction between organisms
  • positive regulation of translation
  • nuclease activity
  • NAS6
  • proteasome regulatory particle
  • proteolysis
  • molecular_function
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN14
  • cytoplasm
  • proteasome regulatory particle
  • proteolysis
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN3
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT5
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • STI1
  • cytoplasm
  • protein folding
  • chaperone inhibitor activity
  • chaperone activator activity
  • Hsp90 protein binding
  • Hsp70 protein binding
  • UBC12
  • cellular_component
  • protein neddylation
  • nucleotide binding
  • ATP binding
  • ubiquitin-protein ligase activity
  • acid-amino acid ligase activity
  • NEDD8 ligase activity
  • small conjugating protein ligase activity
  • ligase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome accessory complex 6.319E-37 24 23 16 6292
    proteasome regulatory particle 6.319E-37 24 23 16 6292
    proteasome complex 5.6396E-30 24 48 16 6292
    proteasome regulatory particle, lid subcomplex 5.4319E-19 24 10 8 6292
    proteasome regulatory particle, base subcomplex 1.3054E-13 24 9 6 6292
    protein complex 2.0166E-8 24 1137 17 6292
    macromolecular complex 6.8573E-7 24 1635 18 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteolysis 1.2729E-19 24 188 16 6292
    modification-dependent protein catabolic process 4.5051E-19 24 156 15 6292
    ubiquitin-dependent protein catabolic process 4.5051E-19 24 156 15 6292
    proteolysis involved in cellular protein catabolic process 6.0518E-19 24 159 15 6292
    modification-dependent macromolecule catabolic process 9.7702E-19 24 164 15 6292
    cellular protein catabolic process 1.8625E-18 24 171 15 6292
    protein catabolic process 8.6728E-18 24 189 15 6292
    cellular macromolecule catabolic process 1.4673E-15 24 265 15 6292
    macromolecule catabolic process 6.9664E-15 24 294 15 6292
    cellular catabolic process 4.3805E-14 24 415 16 6292
    catabolic process 7.1833E-13 24 496 16 6292
    protein metabolic process 5.9682E-12 24 1136 20 6292
    cellular protein metabolic process 4.0277E-11 24 1074 19 6292
    macromolecule metabolic process 5.3267E-7 24 2349 21 6292
    cellular macromolecule metabolic process 2.9819E-6 24 2285 20 6292
    primary metabolic process 3.2181E-6 24 2896 22 6292
    metabolic process 1.8675E-5 24 3157 22 6292
    cellular metabolic process 6.8867E-5 24 3033 21 6292
    interspecies interaction between organisms 7.6148E-3 24 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 1.1365E-11 24 54 8 6292
    peptidase activity, acting on L-amino acid peptides 1.209E-9 24 95 8 6292
    peptidase activity 3.1438E-7 24 192 8 6292
    ATPase activity 1.0744E-4 24 211 6 6292
    hydrolase activity 1.0944E-3 24 911 10 6292
    nucleoside-triphosphatase activity 1.178E-3 24 329 6 6292
    hydrolase activity, acting on acid anhydrides 1.6969E-3 24 353 6 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.6969E-3 24 353 6 6292
    pyrophosphatase activity 1.6969E-3 24 353 6 6292
    ATP binding 3.6566E-3 24 24 2 6292
    chaperone inhibitor activity 3.8144E-3 24 1 1 6292
    NEDD8 ligase activity 3.8144E-3 24 1 1 6292
    adenyl ribonucleotide binding 3.9653E-3 24 25 2 6292
    adenyl nucleotide binding 5.6833E-3 24 30 2 6292
    purine nucleoside binding 6.0611E-3 24 31 2 6292
    nucleoside binding 6.4502E-3 24 32 2 6292
    Hsp70 protein binding 7.6148E-3 24 2 1 6292
    isocitrate dehydrogenase (NAD+) activity 7.6148E-3 24 2 1 6292
    Hsp90 protein binding 7.6148E-3 24 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle