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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Spt2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AAC3
  • mitochondrion
  • mitochondrial inner membrane
  • anaerobic respiration
  • ATP:ADP antiporter activity
  • CYS4
  • cytoplasm
  • mitochondrion
  • response to drug
  • cysteine biosynthetic process
  • cystathionine beta-synthase activity
  • GND1
  • cytoplasm
  • mitochondrion
  • response to oxidative stress
  • pentose-phosphate shunt, oxidative branch
  • phosphogluconate dehydrogenase (decarboxylating) activity
  • GSP1
  • nucleus
  • cytoplasm
  • nucleocytoplasmic transport
  • rRNA processing
  • nucleus organization
  • GTPase activity
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RLI1
  • nucleus
  • cytoplasm
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • translational initiation
  • ATPase activity
  • iron ion binding
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • SPT2
  • nucleus
  • negative regulation of transcription from RNA polymerase II promoter
  • RNA polyadenylation
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
  • DNA binding
  • DNA secondary structure binding
  • SRP1
  • nucleus
  • cytoplasm
  • nucleocytoplasmic transport
  • protein transmembrane transporter activity
  • SSF1
  • nucleolus
  • conjugation with cellular fusion
  • regulation of cell size
  • ribosomal large subunit assembly
  • rRNA binding
  • STE23
  • integral to membrane
  • proteolysis
  • peptide pheromone maturation
  • metallopeptidase activity
  • SUP45
  • cytosol
  • translation release factor complex
  • translational termination
  • cytokinesis
  • translation release factor activity, codon specific
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • UTP7
  • nuclear outer membrane
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.3059E-4 16 211 5 6292
    nuclear lumen 4.2469E-3 16 453 5 6292
    translation release factor complex 5.0798E-3 16 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 6.7375E-7 16 346 8 6292
    ribonucleoprotein complex biogenesis 1.2221E-6 16 374 8 6292
    cellular component biogenesis 1.2064E-4 16 694 8 6292
    rRNA metabolic process 3.1944E-4 16 137 4 6292
    ribosomal large subunit biogenesis 5.3537E-4 16 65 3 6292
    gene expression 1.6813E-3 16 1283 9 6292
    ncRNA metabolic process 3.3543E-3 16 257 4 6292
    rRNA processing 3.7938E-3 16 128 3 6292
    nuclear transport 3.9636E-3 16 130 3 6292
    nucleocytoplasmic transport 3.9636E-3 16 130 3 6292
    ribosomal large subunit assembly 4.6924E-3 16 41 2 6292
    translational initiation 4.9198E-3 16 42 2 6292
    cysteine biosynthetic process 5.0798E-3 16 2 1 6292
    anaerobic respiration 5.0798E-3 16 2 1 6292
    ribosomal subunit assembly 8.3236E-3 16 55 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleic acid binding 9.1183E-6 16 666 9 6292
    binding 4.183E-5 16 1294 11 6292
    RNA binding 1.8355E-4 16 367 6 6292
    rRNA binding 7.1262E-4 16 16 2 6292
    7S RNA binding 2.5429E-3 16 1 1 6292
    cystathionine beta-synthase activity 2.5429E-3 16 1 1 6292
    translation release factor activity, codon specific 2.5429E-3 16 1 1 6292
    snoRNA binding 2.7007E-3 16 31 2 6292
    phosphogluconate dehydrogenase (decarboxylating) activity 5.0798E-3 16 2 1 6292
    5S rRNA binding 5.0798E-3 16 2 1 6292
    translation factor activity, nucleic acid binding 5.3895E-3 16 44 2 6292
    ATP:ADP antiporter activity 7.6106E-3 16 3 1 6292
    translation release factor activity 7.6106E-3 16 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle