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The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa). Any process that activates or increases the frequency, rate or extent of translational termination. Any process that stops, prevents or reduces the frequency, rate or extent of translational termination. The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. The disaggregation of a macromolecular complex into its constituent components, carried out at the cellular level. Any process that modulates the frequency, rate or extent of translational termination. The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: translational termination
Acc: GO:0006415
Aspect: Biological Process
Desc: The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
Synonyms:
  • protein synthesis termination
  • GO:0006443
  • translation termination
  • translational complex disassembly
  • GO:0006456
Proteins in PDR annotated with:
   This term: 104 [Search]
   Term or descendants: 122 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0006415 - translational termination (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle