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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Cmd1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CMD1
  • incipient cellular bud site
  • cellular bud tip
  • central plaque of spindle pole body
  • cytoplasm
  • cellular bud neck
  • mating projection tip
  • cytoskeleton organization
  • cell budding
  • vacuole fusion, non-autophagic
  • mitosis
  • endocytosis
  • protein binding
  • calcium ion binding
  • calcium-dependent protein binding
  • CMP2
  • calcineurin complex
  • cytoplasm
  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion
  • cellular ion homeostasis
  • calcium-dependent protein serine/threonine phosphatase activity
  • HUL5
  • nucleus
  • cytoplasm
  • protein polyubiquitination
  • protein monoubiquitination
  • ubiquitin-protein ligase activity
  • MLC1
  • cellular bud tip
  • cellular bud neck
  • vesicle
  • cytokinesis, actomyosin contractile ring assembly
  • vesicle targeting
  • protein localization
  • cytokinesis
  • myosin II heavy chain binding
  • myosin V binding
  • MYO2
  • incipient cellular bud site
  • cellular bud tip
  • cellular bud neck
  • fungal-type vacuole membrane
  • myosin V complex
  • mating projection tip
  • vesicle
  • filamentous actin
  • mitochondrion inheritance
  • vacuole inheritance
  • establishment of mitotic spindle orientation
  • unidimensional cell growth
  • vesicle-mediated transport
  • Golgi inheritance
  • vesicle transport along actin filament
  • peroxisome inheritance
  • membrane addition at site of cytokinesis
  • budding cell apical bud growth
  • actin filament binding
  • calmodulin binding
  • microfilament motor activity
  • MYO3
  • actin cortical patch
  • bipolar cellular bud site selection
  • response to osmotic stress
  • cellular cell wall organization
  • endocytosis
  • exocytosis
  • microfilament motor activity
  • MYO4
  • cellular bud
  • mitochondrion
  • myosin V complex
  • filamentous actin
  • intracellular mRNA localization
  • endoplasmic reticulum inheritance
  • gene conversion at mating-type locus
  • actin filament binding
  • microfilament motor activity
  • MYO5
  • actin cortical patch
  • response to salt stress
  • bipolar cellular bud site selection
  • response to osmotic stress
  • cellular cell wall organization
  • endocytosis
  • exocytosis
  • microfilament motor activity
  • SHE4
  • cytoplasm
  • intracellular mRNA localization
  • actin cytoskeleton organization
  • gene conversion at mating-type locus
  • myosin binding
  • SPC110
  • inner plaque of spindle pole body
  • central plaque of spindle pole body
  • microtubule nucleation
  • structural constituent of cytoskeleton
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoskeletal part 1.863E-7 10 201 6 6292
    cytoskeleton 2.8602E-7 10 216 6 6292
    myosin V complex 2.2737E-6 10 2 2 6292
    filamentous actin 2.2737E-6 10 2 2 6292
    unconventional myosin complex 2.2737E-6 10 2 2 6292
    actin cytoskeleton 6.1249E-6 10 85 4 6292
    myosin complex 6.8153E-6 10 3 2 6292
    central plaque of spindle pole body 2.2679E-5 10 5 2 6292
    cellular bud tip 8.0877E-5 10 57 3 6292
    actin filament 8.1369E-5 10 9 2 6292
    cellular bud 8.6684E-5 10 166 4 6292
    microtubule organizing center part 2.6962E-4 10 16 2 6292
    cellular bud neck 9.0933E-4 10 129 3 6292
    mating projection tip 1.3155E-3 10 35 2 6292
    non-membrane-bounded organelle 1.4928E-3 10 959 6 6292
    intracellular non-membrane-bounded organelle 1.4928E-3 10 959 6 6292
    actin cortical patch 1.8038E-3 10 41 2 6292
    cell projection part 1.8923E-3 10 42 2 6292
    site of polarized growth 1.9542E-3 10 168 3 6292
    incipient cellular bud site 2.1703E-3 10 45 2 6292
    cell projection 2.5693E-3 10 49 2 6292
    mating projection 2.5693E-3 10 49 2 6292
    cortical actin cytoskeleton 2.8897E-3 10 52 2 6292
    cortical cytoskeleton 2.8897E-3 10 52 2 6292
    microtubule organizing center 4.2165E-3 10 63 2 6292
    spindle pole body 4.2165E-3 10 63 2 6292
    spindle pole 4.8974E-3 10 68 2 6292
    inner plaque of spindle pole body 6.3436E-3 10 4 1 6292
    calcineurin complex 6.3436E-3 10 4 1 6292
    spindle 8.2701E-3 10 89 2 6292
    cell cortex part 9.5731E-3 10 96 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    reproduction 1.0297E-7 10 328 7 6292
    reproduction of a single-celled organism 2.9399E-7 10 217 6 6292
    cell division 1.3934E-6 10 145 5 6292
    cell budding 7.6996E-6 10 90 4 6292
    asexual reproduction 7.6996E-6 10 90 4 6292
    cytokinetic process 8.4067E-6 10 92 4 6292
    vesicle localization 1.3619E-5 10 4 2 6292
    cytoskeleton organization 1.3847E-5 10 231 5 6292
    cytokinesis 1.84E-5 10 112 4 6292
    cellular developmental process 3.293E-5 10 276 5 6292
    developmental process 7.9144E-5 10 331 5 6292
    vesicle-mediated transport 9.0018E-5 10 340 5 6292
    intracellular mRNA localization 1.0162E-4 10 10 2 6292
    gene conversion at mating-type locus 1.241E-4 10 11 2 6292
    cellular localization 1.6302E-4 10 643 6 6292
    cellular membrane organization 1.7216E-4 10 198 4 6292
    membrane organization 1.7216E-4 10 198 4 6292
    cell cycle cytokinesis 2.2276E-4 10 80 3 6292
    establishment of cell polarity 2.5747E-4 10 84 3 6292
    establishment or maintenance of cell polarity 2.6667E-4 10 85 3 6292
    mating type switching 2.6962E-4 10 16 2 6292
    localization 2.8293E-4 10 1060 7 6292
    endocytosis 2.9553E-4 10 88 3 6292
    membrane invagination 3.5918E-4 10 94 3 6292
    mating type determination 4.2546E-4 10 20 2 6292
    sex determination 4.2546E-4 10 20 2 6292
    cellular component organization 4.29E-4 10 1582 8 6292
    cell cycle process 5.0875E-4 10 490 5 6292
    cell fate commitment 5.6509E-4 10 23 2 6292
    actin filament-based process 6.8368E-4 10 117 3 6292
    cell cycle 7.0181E-4 10 525 5 6292
    cell morphogenesis 8.2951E-4 10 125 3 6292
    cellular component morphogenesis 1.1065E-3 10 138 3 6292
    mitotic recombination 1.1694E-3 10 33 2 6292
    bipolar cellular bud site selection 1.2414E-3 10 34 2 6292
    Golgi inheritance 1.5893E-3 10 1 1 6292
    organelle inheritance 2.0756E-3 10 44 2 6292
    exocytosis 2.267E-3 10 46 2 6292
    vacuole organization 2.267E-3 10 46 2 6292
    secretion 3.1132E-3 10 54 2 6292
    secretion by cell 3.1132E-3 10 54 2 6292
    unidimensional cell growth 3.1764E-3 10 2 1 6292
    establishment of vesicle localization 3.1764E-3 10 2 1 6292
    endoplasmic reticulum inheritance 3.1764E-3 10 2 1 6292
    developmental growth involved in morphogenesis 3.1764E-3 10 2 1 6292
    membrane addition at site of cytokinesis 3.1764E-3 10 2 1 6292
    vesicle transport along actin filament 3.1764E-3 10 2 1 6292
    actin filament-based movement 3.1764E-3 10 2 1 6292
    developmental growth 3.1764E-3 10 2 1 6292
    vesicle targeting 3.1764E-3 10 2 1 6292
    establishment of organelle localization 3.228E-3 10 55 2 6292
    organelle organization 3.5469E-3 10 1127 6 6292
    peroxisome inheritance 4.7611E-3 10 3 1 6292
    actomyosin structure organization 4.7611E-3 10 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 4.7611E-3 10 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 4.7611E-3 10 3 1 6292
    cellular bud site selection 5.7773E-3 10 74 2 6292
    cytokinesis, site selection 5.7773E-3 10 74 2 6292
    response to osmotic stress 6.2426E-3 10 77 2 6292
    Golgi organization 6.3436E-3 10 4 1 6292
    anatomical structure morphogenesis 6.5282E-3 10 257 3 6292
    anatomical structure development 6.7431E-3 10 260 3 6292
    organelle localization 7.565E-3 10 85 2 6292
    RNA localization 8.8178E-3 10 92 2 6292
    endoplasmic reticulum organization 9.5019E-3 10 6 1 6292
    microtubule cytoskeleton organization 9.7663E-3 10 97 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    microfilament motor activity 1.6082E-11 10 5 4 6292
    motor activity 9.7446E-9 10 18 4 6292
    cytoskeletal protein binding 1.4045E-6 10 59 4 6292
    myosin binding 2.2679E-5 10 5 2 6292
    actin filament binding 1.488E-4 10 12 2 6292
    actin binding 4.6984E-4 10 21 2 6292
    nucleoside-triphosphatase activity 1.1988E-3 10 329 4 6292
    protein binding 1.4242E-3 10 612 5 6292
    hydrolase activity, acting on acid anhydrides 1.5609E-3 10 353 4 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.5609E-3 10 353 4 6292
    pyrophosphatase activity 1.5609E-3 10 353 4 6292
    calcium-dependent protein binding 1.5893E-3 10 1 1 6292
    calmodulin binding 1.5893E-3 10 1 1 6292
    myosin heavy chain binding 1.5893E-3 10 1 1 6292
    myosin II heavy chain binding 1.5893E-3 10 1 1 6292
    myosin V binding 1.5893E-3 10 1 1 6292
    myosin II binding 3.1764E-3 10 2 1 6292
    calcium-dependent protein serine/threonine phosphatase activity 4.7611E-3 10 3 1 6292
    hydrolase activity 8.4227E-3 10 911 5 6292

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