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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Met30. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC53
  • SCF ubiquitin ligase complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding, bridging
  • MET30
  • nucleus
  • SCF ubiquitin ligase complex
  • nuclear SCF ubiquitin ligase complex
  • response to arsenic
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • response to cadmium ion
  • cell cycle
  • protein ubiquitination
  • protein binding
  • MET31
  • nucleus
  • cytoplasm
  • sulfur amino acid metabolic process
  • regulation of transcription
  • DNA binding
  • specific RNA polymerase II transcription factor activity
  • MET4
  • nucleus
  • sulfur amino acid metabolic process
  • response to arsenic
  • response to cadmium ion
  • positive regulation of transcription from RNA polymerase II promoter
  • transcription coactivator activity
  • RUB1
  • cytoplasm
  • protein neddylation
  • protein tag
  • SIS1
  • nucleus
  • cytoplasm
  • cytosolic small ribosomal subunit
  • translational initiation
  • protein folding
  • unfolded protein binding
  • chaperone regulator activity
  • SKP1
  • RAVE complex
  • nucleus
  • cytoplasm
  • CBF3 complex
  • SCF ubiquitin ligase complex
  • kinetochore
  • G2/M transition of mitotic cell cycle
  • protein complex assembly
  • regulation of exit from mitosis
  • G1/S transition of mitotic cell cycle
  • cytokinesis
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • regulation of protein complex assembly
  • protein neddylation
  • kinetochore assembly
  • vacuolar acidification
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
  • DNA replication origin binding
  • ubiquitin-protein ligase activity
  • protein binding
  • TEF4
  • mitochondrion
  • ribosome
  • eukaryotic translation elongation factor 1 complex
  • translational elongation
  • translation elongation factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SCF ubiquitin ligase complex 2.2161E-7 8 11 3 6292
    cullin-RING ubiquitin ligase complex 4.8801E-7 8 14 3 6292
    ubiquitin ligase complex 1.6261E-5 8 43 3 6292
    nuclear SCF ubiquitin ligase complex 2.5415E-3 8 2 1 6292
    RAVE complex 3.8101E-3 8 3 1 6292
    CBF3 complex 5.0773E-3 8 4 1 6292
    eukaryotic translation elongation factor 1 complex 6.3431E-3 8 5 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 4.7121E-8 8 7 3 6292
    protein modification by small protein conjugation 2.1849E-6 8 86 4 6292
    protein modification by small protein conjugation or removal 6.7673E-6 8 114 4 6292
    response to cadmium ion 1.4121E-5 8 5 2 6292
    protein neddylation 2.9615E-5 8 7 2 6292
    response to arsenic 5.0705E-5 8 9 2 6292
    protein ubiquitination 5.6801E-5 8 65 3 6292
    proteasomal protein catabolic process 6.797E-5 8 69 3 6292
    proteasomal ubiquitin-dependent protein catabolic process 6.797E-5 8 69 3 6292
    protein ubiquitination during ubiquitin-dependent protein catabolic process 7.7367E-5 8 11 2 6292
    response to metal ion 2.1426E-4 8 18 2 6292
    cellular macromolecule metabolic process 3.0018E-4 8 2285 8 6292
    macromolecule metabolic process 3.7455E-4 8 2349 8 6292
    cellular protein metabolic process 4.9998E-4 8 1074 6 6292
    G2/M transition of mitotic cell cycle 5.646E-4 8 29 2 6292
    post-translational protein modification 5.9444E-4 8 357 4 6292
    protein metabolic process 6.8696E-4 8 1136 6 6292
    modification-dependent protein catabolic process 7.6403E-4 8 156 3 6292
    ubiquitin-dependent protein catabolic process 7.6403E-4 8 156 3 6292
    sulfur amino acid metabolic process 7.7767E-4 8 34 2 6292
    proteolysis involved in cellular protein catabolic process 8.0779E-4 8 159 3 6292
    response to inorganic substance 8.2428E-4 8 35 2 6292
    modification-dependent macromolecule catabolic process 8.8426E-4 8 164 3 6292
    cellular protein catabolic process 9.989E-4 8 171 3 6292
    proteolysis 1.3159E-3 8 188 3 6292
    protein catabolic process 1.3363E-3 8 189 3 6292
    G1/S transition of mitotic cell cycle 1.6809E-3 8 50 2 6292
    primary metabolic process 2.0036E-3 8 2896 8 6292
    protein modification process 2.1135E-3 8 499 4 6292
    cellular metabolic process 2.9013E-3 8 3033 8 6292
    macromolecule modification 3.4456E-3 8 569 4 6292
    cellular macromolecule catabolic process 3.5334E-3 8 265 3 6292
    centromere complex assembly 3.8101E-3 8 3 1 6292
    kinetochore assembly 3.8101E-3 8 3 1 6292
    kinetochore organization 3.8101E-3 8 3 1 6292
    metabolic process 3.9991E-3 8 3157 8 6292
    macromolecule catabolic process 4.7456E-3 8 294 3 6292
    sulfur metabolic process 5.3571E-3 8 90 2 6292
    interphase of mitotic cell cycle 6.2001E-3 8 97 2 6292
    interphase 6.2001E-3 8 97 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    binding 1.0087E-4 8 1294 7 6292
    DNA replication origin binding 1.0958E-4 8 13 2 6292
    protein binding 3.7374E-4 8 612 5 6292
    sequence-specific DNA binding 1.6809E-3 8 50 2 6292
    ubiquitin-protein ligase activity 2.1802E-3 8 57 2 6292
    small conjugating protein ligase activity 2.575E-3 8 62 2 6292
    DNA binding 3.2017E-3 8 256 3 6292
    acid-amino acid ligase activity 3.3645E-3 8 71 2 6292
    ligase activity, forming carbon-nitrogen bonds 5.8317E-3 8 94 2 6292
    nucleic acid binding 6.1432E-3 8 666 4 6292
    chaperone regulator activity 8.8705E-3 8 7 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle