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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 5 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
GPG1
  • cellular_component
  • signal transduction
  • signal transducer activity
  • SIR2
  • nuclear telomeric heterochromatin
  • RENT complex
  • nucleolus
  • chromatin silencing complex
  • nuclear telomere cap complex
  • chromatin silencing at rDNA
  • loss of chromatin silencing involved in replicative cell aging
  • chromatin assembly or disassembly
  • negative regulation of DNA replication
  • double-strand break repair via nonhomologous end joining
  • chromatin silencing at silent mating-type cassette
  • replicative cell aging
  • chromatin silencing at telomere
  • chronological cell aging
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
  • NAD-dependent histone deacetylase activity
  • SIR3
  • nuclear telomeric heterochromatin
  • mitochondrion
  • nucleolus
  • chromatin silencing complex
  • nuclear telomere cap complex
  • loss of chromatin silencing involved in replicative cell aging
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • structural constituent of chromatin
  • histone binding
  • SIR4
  • nuclear telomeric heterochromatin
  • chromatin silencing complex
  • nuclear telomere cap complex
  • loss of chromatin silencing involved in replicative cell aging
  • telomere maintenance
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • structural constituent of chromatin
  • histone binding
  • YLR278C
  • nucleus
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear telomeric heterochromatin 8.4265E-9 5 7 3 6292
    telomeric heterochromatin 8.4265E-9 5 7 3 6292
    nuclear heterochromatin 8.4265E-9 5 7 3 6292
    heterochromatin 8.4265E-9 5 7 3 6292
    chromatin silencing complex 2.0214E-8 5 9 3 6292
    telomere cap complex 3.9687E-8 5 11 3 6292
    nuclear telomere cap complex 3.9687E-8 5 11 3 6292
    nuclear chromosome, telomeric region 4.2475E-7 5 23 3 6292
    chromosome, telomeric region 7.0086E-7 5 27 3 6292
    protein-DNA complex 6.9607E-6 5 57 3 6292
    nuclear chromatin 1.4739E-5 5 73 3 6292
    chromatin 1.7318E-5 5 77 3 6292
    chromatin remodeling complex 3.6938E-5 5 99 3 6292
    nuclear chromosome part 2.592E-4 5 190 3 6292
    nuclear chromosome 4.4494E-4 5 228 3 6292
    chromosomal part 4.9889E-4 5 237 3 6292
    chromosome 7.6528E-4 5 274 3 6292
    RENT complex 3.1756E-3 5 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    loss of chromatin silencing involved in replicative cell aging 2.0214E-8 5 9 3 6292
    progressive alteration of chromatin involved in replicative cell aging 2.887E-8 5 10 3 6292
    loss of chromatin silencing 2.887E-8 5 10 3 6292
    progressive alteration of chromatin involved in cell aging 3.9687E-8 5 11 3 6292
    positive regulation of gene expression, epigenetic 3.9687E-8 5 11 3 6292
    regulation of gene silencing 3.9687E-8 5 11 3 6292
    negative regulation of gene silencing 3.9687E-8 5 11 3 6292
    regulation of chromatin silencing 3.9687E-8 5 11 3 6292
    negative regulation of chromatin silencing 3.9687E-8 5 11 3 6292
    double-strand break repair via nonhomologous end joining 5.5136E-7 5 25 3 6292
    non-recombinational repair 1.4314E-6 5 34 3 6292
    replicative cell aging 2.016E-6 5 38 3 6292
    cell aging 4.3914E-6 5 49 3 6292
    aging 4.9613E-6 5 51 3 6292
    double-strand break repair 6.9607E-6 5 57 3 6292
    negative regulation of gene expression, epigenetic 3.8071E-5 5 100 3 6292
    gene silencing 3.8071E-5 5 100 3 6292
    regulation of gene expression, epigenetic 3.8071E-5 5 100 3 6292
    chromatin silencing 3.8071E-5 5 100 3 6292
    positive regulation of transcription, DNA-dependent 4.1609E-5 5 103 3 6292
    positive regulation of RNA metabolic process 4.6653E-5 5 107 3 6292
    positive regulation of transcription 5.3507E-5 5 112 3 6292
    positive regulation of gene expression 5.3507E-5 5 112 3 6292
    positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 6.2572E-5 5 118 3 6292
    positive regulation of nitrogen compound metabolic process 6.2572E-5 5 118 3 6292
    positive regulation of macromolecule biosynthetic process 6.2572E-5 5 118 3 6292
    positive regulation of biosynthetic process 6.7461E-5 5 121 3 6292
    positive regulation of cellular biosynthetic process 6.7461E-5 5 121 3 6292
    positive regulation of macromolecule metabolic process 7.6158E-5 5 126 3 6292
    positive regulation of metabolic process 8.1715E-5 5 129 3 6292
    positive regulation of cellular metabolic process 8.1715E-5 5 129 3 6292
    positive regulation of cellular process 9.5706E-5 5 136 3 6292
    positive regulation of biological process 9.7825E-5 5 137 3 6292
    negative regulation of transcription, DNA-dependent 1.4693E-4 5 157 3 6292
    negative regulation of RNA metabolic process 1.4974E-4 5 158 3 6292
    negative regulation of transcription 1.6732E-4 5 164 3 6292
    negative regulation of gene expression 1.6732E-4 5 164 3 6292
    chromatin modification 1.7977E-4 5 168 3 6292
    negative regulation of macromolecule biosynthetic process 2.0299E-4 5 175 3 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.2073E-4 5 180 3 6292
    negative regulation of nitrogen compound metabolic process 2.2073E-4 5 180 3 6292
    negative regulation of biosynthetic process 2.5517E-4 5 189 3 6292
    negative regulation of cellular biosynthetic process 2.5517E-4 5 189 3 6292
    DNA repair 2.6739E-4 5 192 3 6292
    negative regulation of macromolecule metabolic process 2.6739E-4 5 192 3 6292
    chromatin organization 3.1545E-4 5 203 3 6292
    negative regulation of cellular metabolic process 3.439E-4 5 209 3 6292
    negative regulation of metabolic process 3.488E-4 5 210 3 6292
    response to DNA damage stimulus 4.927E-4 5 236 3 6292
    negative regulation of cellular process 5.841E-4 5 250 3 6292
    negative regulation of biological process 6.0502E-4 5 253 3 6292
    cellular response to stress 9.043E-4 5 290 3 6292
    regulation of cellular process 1.1441E-3 5 796 4 6292
    regulation of biological process 1.3089E-3 5 824 4 6292
    developmental process 1.3328E-3 5 331 3 6292
    regulation of transcription, DNA-dependent 1.6762E-3 5 358 3 6292
    regulation of RNA metabolic process 1.7454E-3 5 363 3 6292
    cellular response to stimulus 1.9794E-3 5 379 3 6292
    regulation of transcription 2.0564E-3 5 384 3 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.5772E-3 5 415 3 6292
    regulation of nitrogen compound metabolic process 2.5953E-3 5 416 3 6292
    regulation of gene expression 3.1553E-3 5 445 3 6292
    regulation of macromolecule biosynthetic process 3.3863E-3 5 456 3 6292
    regulation of cellular biosynthetic process 3.7412E-3 5 472 3 6292
    regulation of biosynthetic process 3.7641E-3 5 473 3 6292
    regulation of macromolecule metabolic process 4.1189E-3 5 488 3 6292
    response to stress 4.3416E-3 5 497 3 6292
    transcription, DNA-dependent 4.4943E-3 5 503 3 6292
    RNA biosynthetic process 4.6241E-3 5 508 3 6292
    regulation of primary metabolic process 4.783E-3 5 514 3 6292
    regulation of cellular metabolic process 5.3949E-3 5 536 3 6292
    regulation of metabolic process 5.7186E-3 5 547 3 6292
    biological regulation 5.8209E-3 5 1213 4 6292
    transcription 5.8697E-3 5 552 3 6292
    chromosome organization 5.9616E-3 5 555 3 6292
    DNA metabolic process 6.9303E-3 5 585 3 6292
    negative regulation of DNA replication 7.1338E-3 5 9 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of chromatin 5.0527E-7 5 2 2 6292
    histone binding 4.5804E-5 5 14 2 6292
    NAD-dependent histone deacetylase activity (H3-K9 specific) 7.9466E-4 5 1 1 6292
    NAD-dependent histone deacetylase activity (H3-K14 specific) 7.9466E-4 5 1 1 6292
    NAD-dependent histone deacetylase activity (H4-K16 specific) 7.9466E-4 5 1 1 6292
    histone deacetylase activity (H3-K14 specific) 7.9466E-4 5 1 1 6292
    histone deacetylase activity (H3-K9 specific) 7.9466E-4 5 1 1 6292
    NAD-dependent protein deacetylase activity 7.1338E-3 5 9 1 6292
    NAD-dependent histone deacetylase activity 7.1338E-3 5 9 1 6292

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