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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 6.4005E-19 14 211 13 6292
    nuclear lumen 1.5554E-14 14 453 13 6292
    organelle lumen 2.1184E-12 14 660 13 6292
    intracellular organelle lumen 2.1184E-12 14 660 13 6292
    membrane-enclosed lumen 4.5533E-12 14 700 13 6292
    non-membrane-bounded organelle 2.6914E-10 14 959 13 6292
    intracellular non-membrane-bounded organelle 2.6914E-10 14 959 13 6292
    nuclear part 1.6352E-9 14 1103 13 6292
    nucleus 1.3856E-7 14 2041 14 6292
    preribosome, large subunit precursor 7.3106E-7 14 9 3 6292
    intracellular organelle part 1.7098E-5 14 2282 13 6292
    organelle part 1.7098E-5 14 2282 13 6292
    nuclear outer membrane 2.9342E-5 14 86 4 6292
    nuclear membrane 4.7204E-5 14 97 4 6292
    nuclear envelope 4.7744E-5 14 199 5 6292
    preribosome 5.0397E-5 14 34 3 6292
    outer membrane 4.9634E-4 14 178 4 6292
    organelle outer membrane 4.9634E-4 14 178 4 6292
    membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    endomembrane system 1.227E-3 14 398 5 6292
    nuclear membrane-endoplasmic reticulum network 1.3464E-3 14 232 4 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292
    envelope 3.5497E-3 14 505 5 6292
    organelle envelope 3.5497E-3 14 505 5 6292
    Noc2p-Noc3p complex 4.4455E-3 14 2 1 6292
    Noc1p-Noc2p complex 4.4455E-3 14 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.7971E-18 14 346 14 6292
    ribonucleoprotein complex biogenesis 5.4511E-18 14 374 14 6292
    ribosomal large subunit biogenesis 6.5226E-18 14 65 10 6292
    cellular component biogenesis 3.5072E-14 14 694 14 6292
    ribosome assembly 1.7335E-7 14 64 5 6292
    organelle assembly 2.5399E-7 14 69 5 6292
    ribonucleoprotein complex assembly 1.0811E-6 14 92 5 6292
    processing of 27S pre-rRNA 4.8291E-6 14 16 3 6292
    establishment of ribosome localization 2.2128E-5 14 26 3 6292
    ribosome localization 2.2128E-5 14 26 3 6292
    ribosomal subunit export from nucleus 2.2128E-5 14 26 3 6292
    cellular macromolecular complex assembly 3.104E-5 14 182 5 6292
    ribosomal large subunit assembly 8.8955E-5 14 41 3 6292
    rRNA processing 1.3967E-4 14 128 4 6292
    cellular macromolecular complex subunit organization 1.6767E-4 14 259 5 6292
    rRNA metabolic process 1.8175E-4 14 137 4 6292
    ribosomal subunit assembly 2.1493E-4 14 55 3 6292
    establishment of organelle localization 2.1493E-4 14 55 3 6292
    macromolecular complex assembly 2.461E-4 14 281 5 6292
    obsolete_biological_process 2.7851E-4 14 60 3 6292
    macromolecular complex subunit organization 7.4743E-4 14 357 5 6292
    organelle localization 7.7786E-4 14 85 3 6292
    ncRNA processing 1.0131E-3 14 215 4 6292
    cellular component assembly 1.0553E-3 14 385 5 6292
    nuclear export 1.3601E-3 14 103 3 6292
    ncRNA metabolic process 1.9678E-3 14 257 4 6292
    nuclear transport 2.6553E-3 14 130 3 6292
    nucleocytoplasmic transport 2.6553E-3 14 130 3 6292
    actomyosin structure organization 6.6614E-3 14 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 6.6614E-3 14 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 6.6614E-3 14 3 1 6292
    cellular process 7.2188E-3 14 4426 14 6292
    RNA processing 8.0733E-3 14 380 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 2.7809E-5 14 28 3 6292
    RNA-dependent ATPase activity 3.0977E-5 14 29 3 6292
    RNA helicase activity 9.5672E-5 14 42 3 6292
    ATP-dependent helicase activity 1.4301E-4 14 48 3 6292
    purine NTP-dependent helicase activity 1.4301E-4 14 48 3 6292
    helicase activity 7.2551E-4 14 83 3 6292
    ribosomal large subunit binding 2.225E-3 14 1 1 6292
    7S RNA binding 2.225E-3 14 1 1 6292
    ATPase activity, coupled 3.9107E-3 14 149 3 6292
    5S rRNA binding 4.4455E-3 14 2 1 6292
    nucleoside-triphosphatase activity 4.837E-3 14 329 4 6292
    hydrolase activity, acting on acid anhydrides 6.2205E-3 14 353 4 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.2205E-3 14 353 4 6292
    pyrophosphatase activity 6.2205E-3 14 353 4 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle