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Protein Overview: SPO1

General Information:
Name(s) found: SPO1 / YNL012W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 631 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: meiosis [IMPLink to PubMed article]
    Molecular Function: phospholipase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKLLFVFSV LLTVVLATAP FQVQCPSSPL IREAKHELCP EETLYLKKKK IKTKNKLIQF  60
   61 LKSLTEAKFS SKFYKRVLKD PPKIGIAISG GGYRSMLVGT GFISQMNDYG LFEYSDYIAG 120
  121 LSGGSWILMD LVVQNFEVKS LLQEWDLEED LLLGIPEFDI SEEEIVTNAK KEYNDNDLKM 180
  181 KKRQGGSLIT SSSNFYEQIE EIMNSIEEIP EDYMITKRNL NPLARLKKIF FPNNTFTGTD 240
  241 AKIETFKKVL DFYKSLHLKI KPKKMEGFQI SFTDYWGKAI VQRLKKNFDD DPNHSFSFSK 300
  301 LVNSSKKFKE CSVPIPIFVA NCKNGLLSNV IFEFTPFEFG SWENILRLFV KLPYLGSKIV 360
  361 SGKAEKCINN FDDLGFITAT SSSIFNNVLI FIWNLASQSS REAMKALNMV MGIFGLGKEE 420
  421 IFSISKDSSR LETDYAVYQP NPFYLYPEKD NVLTNKNHLY LVDGGEDGEN IPLRTLVIPE 480
  481 RELDVIFVLD SSSDIDNYPN GSKLKRIFEK LDEENVHYQF PNNVKTFTHP IVIGCNATKR 540
  541 TGHDSFLPII IYHANANHGN ASNTSTFKIT YNQSEVSSML PTGRGVFSND YDLYYKNCLG 600
  601 CILTKRTMDR LPRKKKFSPF CLQCFKDYCY S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPO1 SPO23 2 Uetz P, et al. (2000)
    View Screen SPO1 DDR2 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..631] PSI-BLAST 93.522879 Domain from cytosolic phospholipase A2; Cytosolic phospholipase A2 catalytic domain
    2 View Details [563..631] FFAS03 1.74 Domain from cytosolic phospholipase A2; Cytosolic phospholipase A2 catalytic domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle