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Protein Overview: LBX1_MOUSE

General Information:
Name(s) found: LBX1_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|47059020|ref|NP_034821.2| ladybird homeobox homolog 1 [Mus musculus] [NCBI NR]
  • gi|29893132|dbj|BAC75634.1| Lbx1 [Mus musculus] [NCBI NR]
  • gi|148710004|gb|EDL41950.1| ladybird homeobox homolog 1 (Drosophila) [Mus musculus] [NCBI NR]
  • gi|117949814|sp|P52955.2|LBX1_MOUSE RecName: Full=Transcription factor LBX1; AltName: Full=Ladybird homeobox protein homolog 1 [NCBI NR]
  • gi|112362273|gb|AAI20587.1| Ladybird homeobox homolog 1 (Drosophila) [Mus musculus] [NCBI NR]
  • gi|110831741|gb|AAI19178.1| Ladybird homeobox homolog 1 (Drosophila) [Mus musculus] [NCBI NR]
  • Transcription factor LBX1 OS=Mus musculus GN=Lbx1 PE=1 SV=2 [Swiss-Prot]
  • lady bird-like homeobox 1 homolog; lady bird-like homeobox 1 homolog, (Drosophila) [071204_hmrz_cont.fasta]
  • Lbx1 [ipi.MOUSE.v3.06.fasta]
  • lady bird-like homeobox 1 homolog [Mus musculus]gi|29893132|dbj|BAC75634.1| Lbx1 [Mus musculus] [nrdb_11152004_Chlamydomonas]
  • ladybird homeobox homolog 1 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Tax_Id=10090 Lbx1 [EBI-IPI_mouse_3.06_05-10-2005_origrev_con.fasta]
  • Transcription factor LBX1 (Ladybird homeobox protein homolog 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ladybird homeobox homolog 1 (Drosophila) [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Ladybird homeobox homolog 1 (Drosophila) [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Lbx1 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 LBX1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Lbx1 Transcription factor LBX1 [mouse-ipi-250309-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Lbx1 Transcription factor LBX1 ENSMUSG00000025216 IPI00132589 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • transcription factor LBX1 [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta]
  • IPI:IPI00132589.2|SWISS-PROT:P52955|ENSEMBL:ENSMUSP00000096997|REFSEQ:NP_034821 Tax_Id=10090 Gene_Symbol=Lbx1 Transcription factor LBX1 [ipi.MOUSE.fasta.20090209]
  • Transcription factor LBX1 OS=Mus musculus GN=Lbx1 [011711_HMR.fasta]
  • sp|P52955|LBX1_MOUSE Transcription factor LBX1 OS=Mus musculus GN=Lbx1 PE=1 SV=2 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 282 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    transcription factor complex [IDA]
    Biological Process: transcription [IEA]
    multicellular organismal development [IEA]
    negative regulation of cell proliferation [IMP]
    nervous system development [IEA]
    negative regulation of neuron differentiation [IMP]
    regulation of transcription, DNA-dependent [IDA]
    regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification [IMP]
    regulation of transcription [IEA]
    muscle organ development [IEA]
    neuron fate determination [IGI][IMP]
    neuron fate commitment [IMP]
    cell differentiation [IEA]
    heart looping [IMP]
    Molecular Function: DNA binding [IEA]
    transcription factor activity [IDA]
    protein binding [IPI]
    transcription regulator activity [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS YSLCGAAHLL  60
   61 AAADKHAPGG LPLAGRALLS QTSPLCALEE LASKTFKGLE VSVLQAAEGR DGMTIFGQRQ 120
  121 TPKKRRKSRT AFTNHQIYEL EKRFLYQKYL SPADRDQIAQ QLGLTNAQVI TWFQNRRAKL 180
  181 KRDLEEMKAD VESAKKLGPS GQMDIVALAE LEQNSEASGG GGGGGCGRAK SRPGSPALPP 240
  241 GAPQAPGGGP LQLSPASPLT DQRASSQDCS EDEEDEEIDV DD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..107] deduced N/A No confident structure predictions are available.
    2 View Details [108..189] PSI-BLAST 24.69897 Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
    3 View Details [190..282] MSA 2.288996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • serum response element binding
    		•  0.32349914936049 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle