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Protein Overview: SPHK1_RAT

General Information:
Name(s) found: SPHK1_RAT [Swiss-Prot]
Description(s) found:
Found 19 descriptions.
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  • Sphingosine kinase 1 OS=Rattus norvegicus GN=Sphk1 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 383 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN]
    soluble fraction [UNKNOWN]
    cytoplasm [UNKNOWN]
    synaptic vesicle [IDA]
    cytosol [UNKNOWN][IDA]
    neuron projection [IDA]
    plasma membrane [IDA]
    axon [IDA]
    Biological Process: positive regulation of cell proliferation [UNKNOWN]
    response to progesterone stimulus [IEP]
    positive regulation of angiogenesis [UNKNOWN]
    positive regulation of smooth muscle contraction [UNKNOWN]
    inflammatory response [UNKNOWN]
    positive regulation of cell growth [UNKNOWN]
    blood vessel development [UNKNOWN]
    positive regulation of fibroblast proliferation [UNKNOWN]
    response to magnesium ion [IEP]
    positive regulation of neuron projection development [IMP]
    cellular response to hydrogen peroxide [IEP]
    calcium-mediated signaling [UNKNOWN]
    response to protein stimulus [IEP]
    response to ATP [IEP]
    response to amine stimulus [IEP]
    female pregnancy [IEP]
    brain development [UNKNOWN]
    cellular response to starvation [IEP]
    response to organic cyclic substance [IEP]
    activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway [IEA]
    positive regulation of mitotic cell cycle [UNKNOWN]
    cyclooxygenase pathway [IDA]
    negative regulation of apoptosis [IMP]
    positive regulation of protein amino acid phosphorylation [IMP]
    positive regulation of neurotransmitter secretion [IMP]
    response to interleukin-1 [IEP]
    regulation of interleukin-1 beta production [UNKNOWN]
    positive regulation of cell migration [UNKNOWN][IMP]
    Molecular Function: magnesium ion binding [UNKNOWN]
    sphinganine kinase activity [UNKNOWN]
    DNA binding [UNKNOWN]
    ATP binding [UNKNOWN]
    calmodulin binding [UNKNOWN]
    protein binding [UNKNOWN][IPI]
    D-erythro-sphingosine kinase activity [UNKNOWN][IDA]
    diacylglycerol kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPADCPRGL LPRPCRVLVL LNPRGGKGKA LKLFQSRVRP LLEEAEVSFK LMLTERQNHA  60
   61 RELVCAEELG HWDALAVMSG DGLMHEVVNG LMERPDWESA IQKPLCSLPG GSGNALAASL 120
  121 NYYAGHEQVT NEDLLINCTL LLCCRQLSPM NLLSLHTASG RQLYSVLSLS WGFVADVDLE 180
  181 SEKYRSLGEI RFTVGTFFRL ASLRIYQGQL AYLPVGKAAS KIPASSLAQK GPANTYLVPL 240
  241 EEPVPPHWTV VPEQDFVLVL VLLHTHLSTE MFAAPMGRCE AGVMHLFYIR AGVSRAMLVR 300
  301 LFLAMQKGKH MDLDCPYLVH VPVVAFRLEP RNQRGVFSVD GELMVCEAVQ GQVHPNYLWM 360
  361 VSGSSDSPSG RDSQRRPPPE EPI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle