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Protein Overview: rn-PE

General Information:
Name(s) found: rn-PE / FBpp0289745 [FlyBase]
Description(s) found:
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  • gi|75026999|sp|Q9VI93.2|RN_DROME RecName: Full=Zinc finger protein rotund; AltName: Full=Zinc finger protein roughened eye [NCBI NR]
  • gi|45550706|ref|NP_649715.2| rotund, isoform E [Drosophila melanogaster] [NCBI NR]
  • gi|45446381|gb|AAF54032.3| rotund, isoform E [Drosophila melanogaster] [NCBI NR]
  • Zinc finger protein rotund OS=Drosophila melanogaster GN=rn PE=1 SV=2 [Swiss-Prot]
  • The gene rotund is referred to in FlyBase by the symbol Dmel\rn (CG42277, FBgn0259172). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:3099460..3135119. It has the cytological map location 84D3. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of transcription; compound eye development; imaginal disc-derived leg morphogenesis. 70 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; external compound sense organ; peripheral nervous system; thoracic segment; metatarsus; appendage segment; nervous system; female germline cyst; antennal segment. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • (AAF54032) CG32466-PA [DrosMelano7227.FASTAC.txt]
  • CG32466-PA, isoform A [Drosophila melanogaster]gi|45550706|ref|NP_649715.2| CG32466-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(3099764..3100080,3100717..3101755,3117586..3117866,3118110..3118160,3120134..3120173,3121426..3121527,3126359..3126898,3133579..3134049); ID=FBpp0289745; name=rn-PE; parent=FBgn0259172,FBtr0300518; dbxref=FlyBase:FBpp028974 [fly-100309-contam.fasta]
  • rotund CG32466-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG32466-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(3099764..3100080,3100717..3101755,3117586..3117866,3118110..3118160,3120134..3120173,3121426..3121527,3126359..3126898,3133579..3134049); ID=FBpp0289745; name=rn-PE; parent=FBgn0259172,FBtr0300518; dbxref=FlyBase:FBpp0289745,FlyBase_Annotation_IDs:CG42277-PE,REFSEQ:NP_649715,GB_protein:AAF54032; MD5=211e7810319aebcbdbb863107f863e0e; length=946; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(3099764..3100080,3100717..3101755,3117586..3117866,3118110..3118160,3120134..3120173,3121426..3121527,3126359..3126898,3133579..3134049); ID=FBpp0289745; name=rn-PE; parent=FBgn0259172,FBtr0300518; dbxref=FlyBase:FBpp0289745,FlyBase_Annotation_IDs:CG42277-PE,REFSEQ:NP_649715,GB_protein:AAF54032; MD5=211e7810319aebcbdbb863107f863e0e; length=946; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:complement(3099764..3100080,3100717..3101755,3117586..3117866,3118110..3118160,3120134..3120173,3121426..3121527,3126359..3126898,3133579..3134049); ID=FBpp0289745; name=rn-PE; parent=FBgn0259172,FBtr0300518; dbxref=FlyBase:FBpp0289745,FlyBase_Annotation_IDs:CG42277-PE,REFSEQ:NP_649715,GB_protein:AAF54032,FlyMine:FBpp0289745,modMine:FBpp0289745; MD5=211e7810319aebcbdbb863107f863e0e; length=946; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(7307857..7308327,7300637..7301176,7295704..7295805,7294412..7294451,7292388..7292438,7291864..7292144,7274995..7276033,7274042..7274358)); ID=FBpp0289745; name=rn-PE; parent=FBgn0267337,FBtr0300518; dbxref=FlyBase:FBpp0289745,FlyBase_Annotation_IDs:CG42277-PE,REFSEQ:NP_649715,GB_protein:AAF54032,FlyMine:FBpp0289745,modMine:FBpp0289745; MD5=211e7810319aebcbdbb863107f863e0e; length=946; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(7307857..7308327,7300637..7301176,7295704..7295805,7294412..7294451,7292388..7292438,7291864..7292144,7274995..7276033,7274042..7274358)); ID=FBpp0289745; name=rn-PE; parent=FBgn0267337,FBtr0300518; dbxref=FlyBase:FBpp0289745,FlyBase_Annotation_IDs:CG42277-PE,REFSEQ:NP_649715,GB_protein:AAF54032,FlyMine:FBpp0289745,modMine:FBpp0289745; MD5=211e7810319aebcbdbb863107f863e0e; length=946; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0289745 type=protein; loc=3R:complement(join(7307857..7308327,7300637..7301176,7295704..7295805,7294412..7294451,7292388..7292438,7291864..7292144,7274995..7276033,7274042..7274358)); ID=FBpp0289745; name=rn-PE; parent=FBgn0267337,FBtr0300518; dbxref=FlyBase:FBpp0289745,FlyBase_Annotation_IDs:CG42277-PE,REFSEQ:NP_649715,GB_protein:AAF54032,FlyMine:FBpp0289745,modMine:FBpp0289745; MD5=211e7810319aebcbdbb863107f863e0e; length=946; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(7307857..7308327,7300637..7301176,7295704..7295805,7294412..7294451,7292388..7292438,7291864..7292144,7274995..7276033,7274042..7274358)); ID=FBpp0289745; name=rn-PE; parent=FBgn0267337,FBtr0300518; dbxref=FlyBase:FBpp0289745,FlyBase_Annotation_IDs:CG42277-PE,REFSEQ:NP_649715,GB_protein:AAF54032,UniProt/Swiss-Prot:Q9VI93,FlyMine:FBpp0289745,modMine:FBpp0289745; MD5=211e7810319aebcbdbb863107f863e0e; length=946; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 946 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: imaginal disc-derived leg morphogenesis [IMP]
    negative regulation of transcription [IMP]
    regulation of transcription [ISS]
    compound eye development [IMP]
    Molecular Function: transcription factor activity [ISS]
    zinc ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIMHGTWYKG PQLAHHPHSN PHNSSHGHSD YHQFRSYPSF VVTPYHDGHV QGPATPTPCT  60
   61 APPTPCNGPV PVSVPVSIPV CHTGGQGSPV IVESSFAIAA AAAAAAAAVA VGGSSATPLL 120
  121 PSPPIKIEQV FGEPSSLGAV VEDYALGLDC PVEHTFRKPH NNNGYSWSTG NNNEVVSHSS 180
  181 NGHTNNHPTT PPTPPNEASA TQATSVSAIN LNQAQPASQT RSNFGSSIKS PPSEPDAVTA 240
  241 ATCKSQENNS GQNPTPNSLS DHNPAHNLNS NSTAAAVAAA AAAAAAANMP IGGVQGQNPT 300
  301 QGLVHWMSAV MAEHMTGQTH HDPGAVGMHY MWNGNVDHAK DISDYNLWPP TPRSHQHASE 360
  361 HHPMSLKQEY EAKMNDHHHN NLQKGHFLDD NRLEHHAVTG QGGLGLGASN GVGGGGGGAS 420
  421 VVGNSSLGAS SHHAVAAAHH HNQAVAAASA AALLVVPQPI NASKMGGPGG VSSVAGGHAT 480
  481 GGGSGRKYQC KMCPQIFSSK ADLQLHTQIH MREAKPYKCT QCSKAFANSS YLSQHTRIHL 540
  541 GIKPYRCEIC QRKFTQLSHL QQHIRTHTGD KPYKCRHPGC QKAFSQLSNL QSHSRCHQTD 600
  601 KPFKCNSCYK CFSDEPSLLE HIPKHKESKH LKTHICQYCG KSYTQETYLT KHMQKHAERT 660
  661 DKRPPIVPGS AAAIAAAAAA AAGGSANPAN GPPPPPNPAQ HQRNNLGLPP VSIAPSDNGY 720
  721 WPKVSPDSAA AANAMEVMHQ QQQQQQQQQQ QQQQQQQQQQ QQAHHHHPQH GVPPQQHVPP 780
  781 QQQQQQQQQQ QHHHPQQQPP PQHSMEAHYA QPTAPNGSQS NGHGAELQPH HRMPDPVRED 840
  841 IASTPSAVGP YDAASITKTT SNSAFTPINS MPPHLNSLSH HPMAQRPYLY DAISFPNKNV 900
  901 NQNNANAFPN QLISLHQIRN YAHQPAGLMA GEHLLGVSVG PGKDKG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..230] MSA 4.176989 View MSA. No confident structure predictions are available.
    2 View Details [231..428] deduced N/A No confident structure predictions are available.
    3 View Details [429..469] MSA 1.499996 View MSA. No confident structure predictions are available.
    4 View Details [470..658] PSI-BLAST 58.045757 No description for 2i13A was found.
    5 View Details [659..752] MSA 1.456995 View MSA. No confident structure predictions are available.
    6 View Details [753..824] PSI-BLAST 8.522879 Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF
    7 View Details [825..946] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • nucleic acid binding
    		•  3.71642591026275 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.66965352784412 bayes_pls_golite062009
  • DNA binding
    		•  3.60136746748155 bayes_pls_golite062009
  • transcription factor activity
    		•  2.54048357633122 bayes_pls_golite062009
  • binding
    		•  2.46754839887217 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.40376744272574 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.29326096340736 bayes_pls_golite062009
  • chromatin binding
    		•  1.30140469366308 bayes_pls_golite062009
  • transcription activator activity
    		•  1.29100548621048 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.73552256979331 bayes_pls_golite062009
  • transcription factor binding
    		•  0.53246783159686 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.52093073106685 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.503526851907562 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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