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Protein Overview: shn-PD

General Information:
Name(s) found: shn-PD / FBpp0089118 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene schnurri is referred to in FlyBase by the symbol Dmel\shn (CG7734, FBgn0003396). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7061325..7104918. It has the cytological map location 47D6-47D7. There is experimental evidence that it has the molecular function</span>: RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: olfactory learning; ectoderm development; learning or memory; cell proliferation; imaginal disc-derived wing vein morphogenesis; wing disc anterior/posterior pattern formation; wing disc dorsal/ventral pattern formation; imaginal disc-derived wing morphogenesis; midgut development. 108 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: organ system; peripheral nervous system; adult segment; embryonic nervous system; adult mesothoracic segment; nervous system; external compound sense organ; primordium; embryonic peripheral nervous system; embryonic head; midgut constriction; podocyte; organ system subdivision; multi-cell-component structure; spiracle. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2577 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    intracellular [IEA]
    Biological Process: dorsal closure [TAS]
    cell proliferation [IMP]
    negative regulation of salivary gland boundary specification [TAS]
    midgut development [IMP]
    negative regulation of cell proliferation [NAS]
    transforming growth factor beta receptor signaling pathway [NAS][TAS]
    imaginal disc-derived wing morphogenesis [IGI][IMP]
    peripheral nervous system development [NAS]
    imaginal disc-derived wing vein morphogenesis [IMP]
    olfactory learning [IMP]
    ectoderm development [IMP]
    learning or memory [IMP]
    wing disc anterior/posterior pattern formation [IMP]
    negative regulation of transcription from RNA polymerase II promoter [NAS]
    compound eye morphogenesis [NAS]
    wing disc dorsal/ventral pattern formation [IGI]
    Molecular Function: transcription factor activity [ISS][NAS]
    zinc ion binding [IEA]
    RNA polymerase II transcription factor activity [IMP][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARRKGSGRG KSTVNSRKSA LETAREKTKD EPTANTSQDN KFDNNMENAT TTTAKHYKTA  60
   61 GKQYKTNKVN NTRRATAAAA AAAAAAATTT VTTAATPTKK RTYRETATAT IVTQRSTNKA 120
  121 NIAAAIALAA ATEATASASA SATATATDAT LTASKAAATA AATTDAASGN SNSSSKPSTS 180
  181 TRDKLGEVPL PTVDSNHIIS NNNNNNNNNN TSNNNNNNHH SDNSISENNY EFKSRDKASL 240
  241 SDSKMTLQQM AAVSSNQEPV APNVANTMSN SSIINSQQTT VNATPATDEA PLGDRSNISR 300
  301 YLHKKFKRLA STTEVDSWSA TNGGGALQAS GDAVRTTSLS SNSSLSPPPT TPLANGHHLM 360
  361 TQQQSHQQVQ QQQQQQQTPP PSVAIHEFSA NFVNSNHVNA IGHEESIISN SGYKAAGRTR 420
  421 TPLANSNSNT NSTSNSNSNH AANATLSPAS FAQHQQLTQP TTVSPGIPGG AAAPNPACEK 480
  481 SGRYVCQYCN LICAKPSVLE KHIRAHTNER PYPCDTCGIA FKTKSNLYKH CRSRSHAARA 540
  541 RGLEVPADAD DGLSDQDAEL SNSSSELPSR AGSPYEEPIN SPTPSPSTLS AAKSAYIQQP 600
  601 PLPTYMQQLP LGSPAAGTLP PTTADNHHSA TAQHRQSIDY KPYKPKFHNA SLYSCSSKEL 660
  661 QQQQQQLQIQ QQQQQHQLAQ QKLSIQLPLV QQPSLAHPTL SPSTQMKMKH HINSHQIQLQ 720
  721 LQQQQSLLAQ QSLLAAMPPG GVYYLGQPSY YNQDTAAAIH QHALAIQQFQ IHLAQQQQQQ 780
  781 QQQHPPLVKA TPPMQQPPSL PPQQLVRANS QISSVATAPA TPTPAANLST FASSSGGKQV 840
  841 NVAKVQEHIS KLISQNEAIV ENKEILLQKK YPKQLSRSRS FNNANSNNAS QHGSNASALH 900
  901 ANNSQNNTNA QMPERETKVN LAQAIFQKQQ HQLQQQQQQQ ITQQQQQQLE QQNYYTYIQQ 960
  961 QQECQQQQLE PPNGVVKRNA YKPGVVMTTP VKQQQQLPPP PSPLPMQTMQ YRQDPATPVT1020
 1021 KIEQPTTAVP VMPLNLSAKP KPTLVTVPVS SLSTSSLAPT PTTSTNPTSS SKTAPPPAQV1080
 1081 NNSIIKNLLL NARGLAVPIG EGDDAVYSCP ICASEFRSAD DLKLHNSTYC QDASSSAPMS1140
 1141 PASSPFRSNS ISLSLPELKS HMANSKNPLS LAKLAWSQLK TKRSSLVLSR LSAAQTPART1200
 1201 STVTAPTVTA SAPAPAVATV TAPSSAPAPQ IEALRFVDAP LPSPGPLLGK TPLVDYAQQS1260
 1261 TPRKAQDSVV ITKMHEDRQF VIEAQPAKRI KTSDLVVASS SQQPTSFNFS FNNQNSSNSV1320
 1321 PELQSSKEER LRRFTSSGGS MIPISECPDL DNSPKMIRTP LLSGGSFQDV SVKVNNETGS1380
 1381 SSKERKLMAL VSGSGLLGVS SGPQHFQFPP INSITAFNPL TLPPMSGGDK TTPVTPIPHV1440
 1441 PGMPGPGSLT PQMPLLPPPP QQLQLPIPSS RGRSPNRKQP SPLLLGGGSG ELKALSPFGG1500
 1501 VQNVPSEFSR QPPTPAQRQA LQWNSKEAPK KAPFNFLRMA DNVKTTEPEV RHFNLENVIS1560
 1561 GKQQELPLTP LHVDTPNGNA PEETSPVASA SASAKSKFLR PTSLPLKPGT FTPKRHHGIT1620
 1621 PTANTLPLIS PETPRPSKSC VQLYLNGHAY TYLGLKCSTK MFYCTVNCPQ PSYVAGMHKL1680
 1681 SMYSVWQVCE ENQPHPLGFK LKQVMALYDS RQRMLGNGSS TAMAGSGKLS YNLVASQQIV1740
 1741 SSPSTSSTSS AFYQGPLKTP PTVTIAALSE ANVAAKANEE AQAKKLETSP SGQPLVGGYE1800
 1801 SHEDYTYIRG RGRGRYVCSE CGIRCKKPSM LKKHIRTHTD VRPFTCSHCN FSFKTKGNLT1860
 1861 KHMQSKTHFK KCIELGINPG PMPPDSEFLD VDMDFDQQSS TSAGGRTSSM AGESDSDDYS1920
 1921 DNESESSDTD ESKSRQKEHE AARGLLSLSM TPPIPQSVSP YPQLQDTPLP AASPANSIGS1980
 1981 SGSQPKRLVC SFTSPKPPFD YQKQEQYYSN PEESKPKRSV ANEESAPMDL TKPRGSILLI2040
 2041 SPSPVSVPAH DLPKSQAQQM HDVIFGTSGN ESGFMKTLIS VSDKVRISAE MEEQAKHEAE2100
 2101 GEDVQLQTYI KEHALHQAKI KQSQFSRSYL INTLYTAASP VMSSSSTLFT ANSRPVMSVN2160
 2161 EVPSIEVHEV KTPEAIESPR SAPEQAPVIL AQIAQEENEE PNIAEPHNAN LPAAVQQPDV2220
 2221 NEFTGVLGNP TAPPTSSVTA TSVSTTTAAP VAPSSTANST QPAQRTVIVG EDGFKSSTPT2280
 2281 SKSGDLQHVS YGRGVPPAPI AGDARPTCTM CSKTFQRQHQ LTLHMNIHYM ERKFKCEPCS2340
 2341 ISFRTQGHLQ KHERSEAHKN KVMMTSTFGV PTTSNPRPFE CTDCKIAFRI HGHLAKHLRS2400
 2401 KTHVQKLECL QKLPFGTYAE IERAGISLTE IDTSDCENSL ISLKLLAQKL QEKDPGKLSS2460
 2461 YTTPSGMMQL AQDAAGPVSQ DSASEDGFSA AIASAIASLD NDSAGNTPKR ASSMSEDETV2520
 2521 ANGLNHSLKR RLPGSFSSTG EESDNPPESS GEKRARSGQE LPVPVAVPVA ASAAASN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] FFAS03 1.48 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    2 View Details [186..364] MSA 1.007997 View MSA. No confident structure predictions are available.
    3 View Details [365..435] deduced N/A No confident structure predictions are available.
    4 View Details [436..536] PSI-BLAST 10.69897 ZIF268
    5 View Details [537..708] PSI-BLAST 19.0 Transcription factor IIIA, TFIIIA
    6 View Details [709..777] PSI-BLAST 24.154902 Designed zinc finger protein
    7 View Details [778..886] deduced N/A No confident structure predictions are available.
    8 View Details [887..1056] deduced N/A No confident structure predictions are available.
    9 View Details [1057..1246] deduced N/A No confident structure predictions are available.
    10 View Details [1247..1466] deduced N/A No confident structure predictions are available.
    11 View Details [1467..1673] deduced N/A No confident structure predictions are available.
    12 View Details [1674..1875] PSI-BLAST 60.30103 No description for 2i13A was found.
    13 View Details [1876..1995] deduced N/A No confident structure predictions are available.
    14 View Details [1996..2118] PSI-BLAST 16.522879 Solution structure of tandem repeat of the zf-C2H2 domains of human zinc finger protein 297B
    15 View Details [2119..2286] FFAS03 1.31 No description for 2j63A was found.
    16 View Details [2287..2415] PSI-BLAST 19.221849 Ying-yang 1 (yy1, zinc finger domain)
    17 View Details [2416..2577] PSI-BLAST 14.0 No description for 2yt9A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.
    12 No functions predicted.
    13 No functions predicted.
    14
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • transcription activator activity
    		•  2.19952417915035 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.42975942698743 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • protein binding
    		•  1.00484935878505 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    15 No functions predicted.
    16 No functions predicted.
    17 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle