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View Structure Prediction Details

Protein: shn-PD
Organism: Drosophila melanogaster
Length: 2577 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for shn-PD.

Description E-value Query
Range		 Subject
Range
gi|109458488 - gi|109458488|ref|XP_574414.2| PREDICTED: similar to Zinc finger protein 208 [Rattus norvegicus]
 1310.0 [0..1454] [2575..265]

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Predicted Domain #1
Region A:
Residues: [1-185] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARRKGSGRG KSTVNSRKSA LETAREKTKD EPTANTSQDN KFDNNMENAT TTTAKHYKTA  60
   61 GKQYKTNKVN NTRRATAAAA AAAAAAATTT VTTAATPTKK RTYRETATAT IVTQRSTNKA 120
  121 NIAAAIALAA ATEATASASA SATATATDAT LTASKAAATA AATTDAASGN SNSSSKPSTS 180
  181 TRDKL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.48
Match: 1h1kI
Description: THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [186-364] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEVPLPTVDS NHIISNNNNN NNNNNTSNNN NNNHHSDNSI SENNYEFKSR DKASLSDSKM  60
   61 TLQQMAAVSS NQEPVAPNVA NTMSNSSIIN SQQTTVNATP ATDEAPLGDR SNISRYLHKK 120
  121 FKRLASTTEV DSWSATNGGG ALQASGDAVR TTSLSSNSSL SPPPTTPLAN GHHLMTQQQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [365-435] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHQQVQQQQQ QQQTPPPSVA IHEFSANFVN SNHVNAIGHE ESIISNSGYK AAGRTRTPLA  60
   61 NSNSNTNSTS N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [436-536] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNSNHAANAT LSPASFAQHQ QLTQPTTVSP GIPGGAAAPN PACEKSGRYV CQYCNLICAK  60
   61 PSVLEKHIRA HTNERPYPCD TCGIAFKTKS NLYKHCRSRS H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 1f2iG
Description: ZIF268
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [537-708] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AARARGLEVP ADADDGLSDQ DAELSNSSSE LPSRAGSPYE EPINSPTPSP STLSAAKSAY  60
   61 IQQPPLPTYM QQLPLGSPAA GTLPPTTADN HHSATAQHRQ SIDYKPYKPK FHNASLYSCS 120
  121 SKELQQQQQQ LQIQQQQQQH QLAQQKLSIQ LPLVQQPSLA HPTLSPSTQM KM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [709-777] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KHHINSHQIQ LQLQQQQSLL AQQSLLAAMP PGGVYYLGQP SYYNQDTAAA IHQHALAIQQ  60
   61 FQIHLAQQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.154902
Match: 1meyC
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [778-886] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQQQQHPPL VKATPPMQQP PSLPPQQLVR ANSQISSVAT APATPTPAAN LSTFASSSGG  60
   61 KQVNVAKVQE HISKLISQNE AIVENKEILL QKKYPKQLSR SRSFNNANS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [887-1056] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNASQHGSNA SALHANNSQN NTNAQMPERE TKVNLAQAIF QKQQHQLQQQ QQQQITQQQQ  60
   61 QQLEQQNYYT YIQQQQECQQ QQLEPPNGVV KRNAYKPGVV MTTPVKQQQQ LPPPPSPLPM 120
  121 QTMQYRQDPA TPVTKIEQPT TAVPVMPLNL SAKPKPTLVT VPVSSLSTSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1057-1246] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAPTPTTSTN PTSSSKTAPP PAQVNNSIIK NLLLNARGLA VPIGEGDDAV YSCPICASEF  60
   61 RSADDLKLHN STYCQDASSS APMSPASSPF RSNSISLSLP ELKSHMANSK NPLSLAKLAW 120
  121 SQLKTKRSSL VLSRLSAAQT PARTSTVTAP TVTASAPAPA VATVTAPSSA PAPQIEALRF 180
  181 VDAPLPSPGP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1247-1466] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLGKTPLVDY AQQSTPRKAQ DSVVITKMHE DRQFVIEAQP AKRIKTSDLV VASSSQQPTS  60
   61 FNFSFNNQNS SNSVPELQSS KEERLRRFTS SGGSMIPISE CPDLDNSPKM IRTPLLSGGS 120
  121 FQDVSVKVNN ETGSSSKERK LMALVSGSGL LGVSSGPQHF QFPPINSITA FNPLTLPPMS 180
  181 GGDKTTPVTP IPHVPGMPGP GSLTPQMPLL PPPPQQLQLP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1467-1673] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPSSRGRSPN RKQPSPLLLG GGSGELKALS PFGGVQNVPS EFSRQPPTPA QRQALQWNSK  60
   61 EAPKKAPFNF LRMADNVKTT EPEVRHFNLE NVISGKQQEL PLTPLHVDTP NGNAPEETSP 120
  121 VASASASAKS KFLRPTSLPL KPGTFTPKRH HGITPTANTL PLISPETPRP SKSCVQLYLN 180
  181 GHAYTYLGLK CSTKMFYCTV NCPQPSY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1674-1875] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAGMHKLSMY SVWQVCEENQ PHPLGFKLKQ VMALYDSRQR MLGNGSSTAM AGSGKLSYNL  60
   61 VASQQIVSSP STSSTSSAFY QGPLKTPPTV TIAALSEANV AAKANEEAQA KKLETSPSGQ 120
  121 PLVGGYESHE DYTYIRGRGR GRYVCSECGI RCKKPSMLKK HIRTHTDVRP FTCSHCNFSF 180
  181 KTKGNLTKHM QSKTHFKKCI EL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.30103
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #13
Region A:
Residues: [1876-1995] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GINPGPMPPD SEFLDVDMDF DQQSSTSAGG RTSSMAGESD SDDYSDNESE SSDTDESKSR  60
   61 QKEHEAARGL LSLSMTPPIP QSVSPYPQLQ DTPLPAASPA NSIGSSGSQP KRLVCSFTSP 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #14
Region A:
Residues: [1996-2118] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPPFDYQKQE QYYSNPEESK PKRSVANEES APMDLTKPRG SILLISPSPV SVPAHDLPKS  60
   61 QAQQMHDVIF GTSGNESGFM KTLISVSDKV RISAEMEEQA KHEAEGEDVQ LQTYIKEHAL 120
  121 HQA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.522879
Match: 2cshA
Description: Solution structure of tandem repeat of the zf-C2H2 domains of human zinc finger protein 297B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #15
Region A:
Residues: [2119-2286] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIKQSQFSRS YLINTLYTAA SPVMSSSSTL FTANSRPVMS VNEVPSIEVH EVKTPEAIES  60
   61 PRSAPEQAPV ILAQIAQEEN EEPNIAEPHN ANLPAAVQQP DVNEFTGVLG NPTAPPTSSV 120
  121 TATSVSTTTA APVAPSSTAN STQPAQRTVI VGEDGFKSST PTSKSGDL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.31
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #16
Region A:
Residues: [2287-2415] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHVSYGRGVP PAPIAGDARP TCTMCSKTFQ RQHQLTLHMN IHYMERKFKC EPCSISFRTQ  60
   61 GHLQKHERSE AHKNKVMMTS TFGVPTTSNP RPFECTDCKI AFRIHGHLAK HLRSKTHVQK 120
  121 LECLQKLPF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 1ubdC
Description: Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #17
Region A:
Residues: [2416-2577] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTYAEIERAG ISLTEIDTSD CENSLISLKL LAQKLQEKDP GKLSSYTTPS GMMQLAQDAA  60
   61 GPVSQDSASE DGFSAAIASA IASLDNDSAG NTPKRASSMS EDETVANGLN HSLKRRLPGS 120
  121 FSSTGEESDN PPESSGEKRA RSGQELPVPV AVPVAASAAA SN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 2yt9A
Description: No description for 2yt9A was found.
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