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Protein Overview: dve-PB

General Information:
Name(s) found: dve-PB / FBpp0089292 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene defective proventriculus is referred to in FlyBase by the symbol Dmel\dve (CG5799, FBgn0020307). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18131468..18173982. It has the cytological map location 58D2. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity; AT DNA binding. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing morphogenesis; midgut development. 32 alleles are reported. The phenotypes of these alleles are annotated with: proventriculus inner layer; dorsal mesothoracic disc; cuprophilic cell; proventriculus outer layer; wing. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 780 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    Biological Process: midgut development [IMP]
    imaginal disc-derived wing morphogenesis [IMP]
    regulation of transcription, DNA-dependent [IEA][ISS]
    regulation of transcription [IEA][TAS]
    Molecular Function: transcription factor activity [ISS][NAS][TAS]
    AT DNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEEAKSLPL HCVVESVHSL HASLTIDTRQ PWKRRPNIET DSYVIIAAAT PWSEIVQTAL  60
   61 QRLGYSQEVA NTARGSLIIK HWKPIPLEQI SDNPAVPVSD IVGELTSVIT LRIVILRPKT 120
  121 SPFGEIKDKL LKLLVLQSHA VLRSTGCPLD EVTLSQICRS SHQNTYALPG GEISDELRRK 180
  181 FDQWWSNQLS PQATAMTPKM LPFMTGPSAV PVPVAVPGEM DFPVGTAMAA AAAAAAHAAA 240
  241 AGGAAGGNPL GSMGSRESLL LANEAAHHAG AGQAPGPGHH GSMLVHPMHA SMHHHHHHGG 300
  301 GGGHGPPYPN QKTRMRTSFD PEMELPKLQK WFADNPHPSR QQIQTYVVQL NALESRRGRK 360
  361 PLDVNNVVYW FKNARAAQKR AEMRGGSLGS AISALGHAAM NGYLSQHAPL GQNSSSSAGS 420
  421 QPMSMGNLSM SHDYLKSPLS LKSEDIDTMS QHSDDMDEEQ SRPNTPQLPL SLTTHERHRS 480
  481 SPLMDEDEDE AGEQQQPQEA KSDGMNGSVK DEERQEKSRD ELQDNEKENS NGEDRHLDAD 540
  541 AQMEASSNLN NNHNNSSLHI EQEVGSTPKR STPKEEDDDL DMDEDEEDNE NDASHLDEFR 600
  601 SPSPDLAGGV VPHKDQLPFP MVPNSMFSQS FMYMSHYIPA FGQAAAGHPH HHAAAAAAAA 660
  661 GIQPNALMGG GGLNLSSISN EERRKRNRTF IDPVTEVPKL EQWFAMNTHP SHNLILKYTE 720
  721 DLNTMPYRQK FPRLESKNVQ FWFKNRRAKC KRLKMSLYDS NQCAQLGGLG SFVPKYEERD 780
  781

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..211] MSA 1.025935 View MSA. No confident structure predictions are available.
    2 View Details [212..294] deduced N/A No confident structure predictions are available.
    3 View Details [295..392] FFAS03 2.63 No description for 2da6A was found.
    4 View Details [393..482] deduced N/A No confident structure predictions are available.
    5 View Details [483..652] MSA 1.191994 View MSA. No confident structure predictions are available.
    6 View Details [653..780] PSI-BLAST 15.09691 Paired protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.45

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle