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Protein Overview: yl-PB

General Information:
Name(s) found: yl-PB / FBpp0073715 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene yolkless is referred to in FlyBase by the symbol Dmel\yl (CG1372, FBgn0004649). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14087252..14093996. It has the cytological map location 12E3. Based on sequence similarity, it is predicted to have molecular function</span>: vitellogenin receptor activity. It is reported to be involved in the biological process</span>: vitellogenesis; oogenesis. 40 alleles are reported. The phenotypes of these alleles are annotated with: stage S13 oocyte; yolk granule; stage S10 oocyte; chorion; egg; coated pit; stage S14 oocyte; coated vesicle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1984 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    cytoplasmic vesicle [IDA]
    coated vesicle [IDA]
    Biological Process: vitellogenesis [NAS]
    oogenesis [NAS][TAS]
    Molecular Function: calcium ion binding [IEA]
    vitellogenin receptor activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCQAEHQVHP SEQRIRVESP KMTASRRGFN LTSQTRAHPS SGGSTSSRYG NCQRTHLIIN  60
   61 GRHVAISLLL LVGLCGGTAA GTPGSADTRC DAGQFQCRDG GCILQAKMCD GRGDCKDSSD 120
  121 ELDCDYRLCR PPHWFPCAQP HGACLAAELM CNGIDNCPGG EDELNCPVRP GFRFGDTAHR 180
  181 MRSCSKYEFM CQQDRTCIPI DFMCDGRPDC TDKSDEVAGC KQAEITCPGE GHLCANGRCL 240
  241 RRKQWVCDGV DDCGDGSDER GCLNLCEPQK GKFLCRNRET CLTLSEVCDG HSDCSDGSDE 300
  301 TDLCHSKPDC DAKKCALGAK CHMMPASGAE CFCPKGFRLA KFEDKCEDVD ECKEQDDLCS 360
  361 QGCENTSGGY RCVCDAGYLL DKDNRTCRAV VYGSKEQQPL LLYTTQMTIM GMHLREDNVR 420
  421 NHVYQVAGNL SKVIGVAYDG SHIYWTNIQN EAESIVKANG DGSNAEILLT SGLDAPEDLA 480
  481 VDWLTQNIYF SDNIMRHIAV CSNDGLNCAV LVTQDVHQPR SLAVWPQKGL MFWTDWGEKP 540
  541 MIGRASMDGS RSRPIVSDNI EWPNGIALDM HQQRIYWVDA KLGSVQTVRP DGTGRRTVLD 600
  601 GMLKHPYGLA IFEDQLYWSD WATKSVHACH KFSGKDHRIL AKDRTIYAVH IYHPAKQPNS 660
  661 PHGCENATCS HLCLLAEPEI GGHSCACPDG MRLAPDHRRC MLMEKRQRLF IGLGQVLLEI 720
  721 EHTAFGRHQV SKSYTLPCLI NEMVYNRING SLIIADNDQR LILEFQPESH ESNVLVRSNL 780
  781 GNVSALAFDH LSRNLYWADT ERAVIEVLSL QTRHRALIRF FPGQEVPIGL TVMPAEGYLY 840
  841 VVLKAKRHSH IDKIPLSGKG EQVHVFEDDL GDDDIKLVTD YETQTIFWSD SDLGRISYSN 900
  901 YRVPHSQIFR GKLRRPYSLA MVHHDLFWNE LGTPRIYWTH KSNMGPRKVI DIMEKDDPAA 960
  961 IMPYVPVATP NGIPLAASSP VGQESHPCQQ QNGGCSHICV GEGPYHSICL CPAGFVYRDA1020
 1021 GNRTCVEALD CEFRCHSGEC LTMNHRCNGR RDCVDNSDEM NCDEEHRRKP KVLCSPNQFA1080
 1081 CHSGEQCVDK ERRCDNRKDC HDHSDEQHCE KFDKSKKCHV HQHGCDNGKC VDSSLVCDGT1140
 1141 NDCGDNSDEL LCEATSRCEP GMFQCGSGSC IAGSWECDGR IDCSDGSDEH DKCVHRSCPP1200
 1201 DMQRCLLGQC LDRSLVCDGH NDCGDKSDEL NCGTDSSTMN ISCAEDQYQC TSNLKICLPS1260
 1261 TVRCNGTTEC PRGEDEADCG DVCSIYEFKC RSGRECIRRE FRCDGQKDCG DGSDELSCEL1320
 1321 EKGHHNQSQI QPWSTSSRSC RPHLFDCQDG ECVDLSRVCN NFPDCTNGHD EGPKCATACR1380
 1381 SASGRQVCQH KCRATPAGAV CSCFDGYRLD ADQKSCLDID ECQEQQPCAQ LCENTLGGYQ1440
 1441 CQCHADFMLR QDRVSCKSLQ SGATLLFSSF NEVRNLSEQP VMLNVAWSAN DSRITGFDLA1500
 1501 MHRQMGYFSA EDEGIVYQID LQTKVIVRAL GLPAPTKLSV DWVTGNVYVL SGAQEIQACS1560
 1561 FVGRMCGRIV HVKSPRHVKH LAVDGYHARI FYIVIRTEGY GQTSSEIHMA RLDGSRRDML1620
 1621 LQRSESFMTA LTTDPHQQLL YFVDQHMRTL ERISYRLKTG PMRRPEIMLQ KSNALMHPSG1680
 1681 LSVYENNAFI VNLGSVEAVQ CALYGSRICH KISINVLNAQ DIVVAGRSRQ PQKASHPCAH1740
 1741 AHCHGLCLQA DYGYECMCGN RLVAEGERCP HGSGNEVAVL GAVNSLELEH EHEQNGHFHW1800
 1801 LMALFVLAAG SLIAGLGYMY YQYRQRGHTD LNINMHFQNP LATLGGTKAF LEHERAEAGV1860
 1861 GFTTETGTVS SRGSNDTFTT TSATSSFAAQ QFSVPNALQR LLRPRQSASG DPMAQELLLE1920
 1921 SPSRESKLHA LDGGGAGGDG DGGRGVGRQV PDILVADMDD DAAKSAGQFG GNYAGNDANA1980
 1981 RFVS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..704] PSI-BLAST 133.0 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    2 View Details [705..1014] PSI-BLAST 70.221849 Crystal structure of Nidogen/Laminin Complex
    3 View Details [1015..1114] FFAS03 2.02 No description for 2gtlO was found.
    4 View Details [1115..1227] PSI-BLAST 6.522879 No description for 2fyjA was found.
    5 View Details [1228..1461] PSI-BLAST 14.0 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    6 View Details [1462..1845] FFAS03 4.78 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains
    7 View Details [1846..1984] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • lipoprotein binding
    		•  7.11457542319896 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  6.26591728596226 bayes_pls_golite062009
  • receptor activity
    		•  4.61995366997272 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.5269049952785 bayes_pls_golite062009
  • vitellogenin receptor activity
    		•  4.1907665151636 bayes_pls_golite062009
  • very-low-density lipoprotein binding
    		•  4.03657063848747 bayes_pls_golite062009
  • very-low-density lipoprotein receptor activity
    		•  4.03657063848747 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.83715772816989 bayes_pls_golite062009
  • signal transducer activity
    		•  3.83715772816989 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  3.74802293475074 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  3.65371958920557 bayes_pls_golite062009
  • lipoprotein receptor binding
    		•  3.5371428063122 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  3.52219710022937 bayes_pls_golite062009
  • apolipoprotein binding
    		•  3.15697162337516 bayes_pls_golite062009
  • heparin binding
    		•  3.15251810133854 bayes_pls_golite062009
  • binding
    		•  3.10919144943954 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16844098063599 bayes_pls_golite062009
  • protein binding
    		•  2.11668700345827 bayes_pls_golite062009
  • receptor binding
    		•  2.00382722979859 bayes_pls_golite062009
  • lipid transporter activity
    		•  1.91872326766441 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  1.88531190199688 bayes_pls_golite062009
  • sterol transporter activity
    		•  1.80087803751379 bayes_pls_golite062009
  • transcription factor binding
    		•  1.71838409809333 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.68241417866789 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.61057978332614 bayes_pls_golite062009
  • growth factor activity
    		•  1.52153421000803 bayes_pls_golite062009
  • lipoprotein transporter activity
    		•  1.44629975873627 bayes_pls_golite062009
  • transporter activity
    		•  1.44005597324471 bayes_pls_golite062009
  • collagen binding
    		•  1.3611207932336 bayes_pls_golite062009
  • pattern binding
    		•  1.26957983931218 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.11978732751628 bayes_pls_golite062009
  • protein kinase activity
    		•  1.00235965838736 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.833222558099761 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.741912411452008 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.72748768329894 bayes_pls_golite062009
  • kinase activity
    		•  0.692244195382463 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.67022333774569 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.66981956037474 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.44857826904729 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.3265100728106 bayes_pls_golite062009
    2
    Term Confidence Notes
  • lipoprotein binding
    		•  7.11457542319896 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  6.26591728596226 bayes_pls_golite062009
  • receptor activity
    		•  4.61995366997272 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.5269049952785 bayes_pls_golite062009
  • vitellogenin receptor activity
    		•  4.1907665151636 bayes_pls_golite062009
  • very-low-density lipoprotein binding
    		•  4.03657063848747 bayes_pls_golite062009
  • very-low-density lipoprotein receptor activity
    		•  4.03657063848747 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.83715772816989 bayes_pls_golite062009
  • signal transducer activity
    		•  3.83715772816989 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  3.65371958920557 bayes_pls_golite062009
  • lipoprotein receptor binding
    		•  3.5371428063122 bayes_pls_golite062009
  • apolipoprotein binding
    		•  3.15697162337516 bayes_pls_golite062009
  • binding
    		•  3.10919144943954 bayes_pls_golite062009
  • protein binding
    		•  2.11668700345827 bayes_pls_golite062009
  • receptor binding
    		•  2.00382722979859 bayes_pls_golite062009
  • lipid transporter activity
    		•  1.91872326766441 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  1.88531190199688 bayes_pls_golite062009
  • sterol transporter activity
    		•  1.80087803751379 bayes_pls_golite062009
  • growth factor activity
    		•  1.52153421000803 bayes_pls_golite062009
  • lipoprotein transporter activity
    		•  1.44629975873627 bayes_pls_golite062009
  • transporter activity
    		•  1.44005597324471 bayes_pls_golite062009
  • collagen binding
    		•  1.3611207932336 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.833222558099761 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.3265100728106 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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