YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: yl-PB
Organism: Drosophila melanogaster
Length: 1984 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for yl-PB.

Description E-value Query
Range		 Subject
Range
gi|7512012, gi|5... - pir||T13171 probable vitellogenin receptor - fruit fly (Drosophila melanogaster), gi|535346|gb|AAB6...
 1319.0 [0..1] [1984..1]

Back

Predicted Domain #1
Region A:
Residues: [1-704] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCQAEHQVHP SEQRIRVESP KMTASRRGFN LTSQTRAHPS SGGSTSSRYG NCQRTHLIIN  60
   61 GRHVAISLLL LVGLCGGTAA GTPGSADTRC DAGQFQCRDG GCILQAKMCD GRGDCKDSSD 120
  121 ELDCDYRLCR PPHWFPCAQP HGACLAAELM CNGIDNCPGG EDELNCPVRP GFRFGDTAHR 180
  181 MRSCSKYEFM CQQDRTCIPI DFMCDGRPDC TDKSDEVAGC KQAEITCPGE GHLCANGRCL 240
  241 RRKQWVCDGV DDCGDGSDER GCLNLCEPQK GKFLCRNRET CLTLSEVCDG HSDCSDGSDE 300
  301 TDLCHSKPDC DAKKCALGAK CHMMPASGAE CFCPKGFRLA KFEDKCEDVD ECKEQDDLCS 360
  361 QGCENTSGGY RCVCDAGYLL DKDNRTCRAV VYGSKEQQPL LLYTTQMTIM GMHLREDNVR 420
  421 NHVYQVAGNL SKVIGVAYDG SHIYWTNIQN EAESIVKANG DGSNAEILLT SGLDAPEDLA 480
  481 VDWLTQNIYF SDNIMRHIAV CSNDGLNCAV LVTQDVHQPR SLAVWPQKGL MFWTDWGEKP 540
  541 MIGRASMDGS RSRPIVSDNI EWPNGIALDM HQQRIYWVDA KLGSVQTVRP DGTGRRTVLD 600
  601 GMLKHPYGLA IFEDQLYWSD WATKSVHACH KFSGKDHRIL AKDRTIYAVH IYHPAKQPNS 660
  661 PHGCENATCS HLCLLAEPEI GGHSCACPDG MRLAPDHRRC MLME

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 133.0
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lipoprotein binding 7.11457542319896 bayes_pls_golite062009
low-density lipoprotein binding 6.26591728596226 bayes_pls_golite062009
receptor activity 4.61995366997272 bayes_pls_golite062009
transmembrane receptor activity 4.5269049952785 bayes_pls_golite062009
vitellogenin receptor activity 4.1907665151636 bayes_pls_golite062009
very-low-density lipoprotein binding 4.03657063848747 bayes_pls_golite062009
very-low-density lipoprotein receptor activity 4.03657063848747 bayes_pls_golite062009
molecular transducer activity 3.83715772816989 bayes_pls_golite062009
signal transducer activity 3.83715772816989 bayes_pls_golite062009
ErbB-2 class receptor binding 3.74802293475074 bayes_pls_golite062009
low-density lipoprotein receptor activity 3.65371958920557 bayes_pls_golite062009
lipoprotein receptor binding 3.5371428063122 bayes_pls_golite062009
ErbB-3 class receptor binding 3.52219710022937 bayes_pls_golite062009
apolipoprotein binding 3.15697162337516 bayes_pls_golite062009
heparin binding 3.15251810133854 bayes_pls_golite062009
binding 3.10919144943954 bayes_pls_golite062009
transcription regulator activity 2.16844098063599 bayes_pls_golite062009
protein binding 2.11668700345827 bayes_pls_golite062009
receptor binding 2.00382722979859 bayes_pls_golite062009
lipid transporter activity 1.91872326766441 bayes_pls_golite062009
lipoprotein receptor activity 1.88531190199688 bayes_pls_golite062009
sterol transporter activity 1.80087803751379 bayes_pls_golite062009
transcription factor binding 1.71838409809333 bayes_pls_golite062009
glycosaminoglycan binding 1.68241417866789 bayes_pls_golite062009
transcription cofactor activity 1.61057978332614 bayes_pls_golite062009
growth factor activity 1.52153421000803 bayes_pls_golite062009
lipoprotein transporter activity 1.44629975873627 bayes_pls_golite062009
transporter activity 1.44005597324471 bayes_pls_golite062009
collagen binding 1.3611207932336 bayes_pls_golite062009
pattern binding 1.26957983931218 bayes_pls_golite062009
polysaccharide binding 1.11978732751628 bayes_pls_golite062009
protein kinase activity 1.00235965838736 bayes_pls_golite062009
substrate-specific transporter activity 0.833222558099761 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.741912411452008 bayes_pls_golite062009
carbohydrate binding 0.72748768329894 bayes_pls_golite062009
kinase activity 0.692244195382463 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.67022333774569 bayes_pls_golite062009
extracellular matrix structural constituent 0.66981956037474 bayes_pls_golite062009
cell adhesion molecule binding 0.44857826904729 bayes_pls_golite062009
extracellular matrix binding 0.3265100728106 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [705-1014] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRQRLFIGLG QVLLEIEHTA FGRHQVSKSY TLPCLINEMV YNRINGSLII ADNDQRLILE  60
   61 FQPESHESNV LVRSNLGNVS ALAFDHLSRN LYWADTERAV IEVLSLQTRH RALIRFFPGQ 120
  121 EVPIGLTVMP AEGYLYVVLK AKRHSHIDKI PLSGKGEQVH VFEDDLGDDD IKLVTDYETQ 180
  181 TIFWSDSDLG RISYSNYRVP HSQIFRGKLR RPYSLAMVHH DLFWNELGTP RIYWTHKSNM 240
  241 GPRKVIDIME KDDPAAIMPY VPVATPNGIP LAASSPVGQE SHPCQQQNGG CSHICVGEGP 300
  301 YHSICLCPAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.221849
Match: 1npeA
Description: Crystal structure of Nidogen/Laminin Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lipoprotein binding 7.11457542319896 bayes_pls_golite062009
low-density lipoprotein binding 6.26591728596226 bayes_pls_golite062009
receptor activity 4.61995366997272 bayes_pls_golite062009
transmembrane receptor activity 4.5269049952785 bayes_pls_golite062009
vitellogenin receptor activity 4.1907665151636 bayes_pls_golite062009
very-low-density lipoprotein binding 4.03657063848747 bayes_pls_golite062009
very-low-density lipoprotein receptor activity 4.03657063848747 bayes_pls_golite062009
molecular transducer activity 3.83715772816989 bayes_pls_golite062009
signal transducer activity 3.83715772816989 bayes_pls_golite062009
low-density lipoprotein receptor activity 3.65371958920557 bayes_pls_golite062009
lipoprotein receptor binding 3.5371428063122 bayes_pls_golite062009
apolipoprotein binding 3.15697162337516 bayes_pls_golite062009
binding 3.10919144943954 bayes_pls_golite062009
protein binding 2.11668700345827 bayes_pls_golite062009
receptor binding 2.00382722979859 bayes_pls_golite062009
lipid transporter activity 1.91872326766441 bayes_pls_golite062009
lipoprotein receptor activity 1.88531190199688 bayes_pls_golite062009
sterol transporter activity 1.80087803751379 bayes_pls_golite062009
growth factor activity 1.52153421000803 bayes_pls_golite062009
lipoprotein transporter activity 1.44629975873627 bayes_pls_golite062009
transporter activity 1.44005597324471 bayes_pls_golite062009
collagen binding 1.3611207932336 bayes_pls_golite062009
substrate-specific transporter activity 0.833222558099761 bayes_pls_golite062009
extracellular matrix binding 0.3265100728106 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [1015-1114] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVYRDAGNRT CVEALDCEFR CHSGECLTMN HRCNGRRDCV DNSDEMNCDE EHRRKPKVLC  60
   61 SPNQFACHSG EQCVDKERRC DNRKDCHDHS DEQHCEKFDK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.02
Match: 2gtlO
Description: No description for 2gtlO was found.

Predicted Domain #4
Region A:
Residues: [1115-1227] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKKCHVHQHG CDNGKCVDSS LVCDGTNDCG DNSDELLCEA TSRCEPGMFQ CGSGSCIAGS  60
   61 WECDGRIDCS DGSDEHDKCV HRSCPPDMQR CLLGQCLDRS LVCDGHNDCG DKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 2fyjA
Description: No description for 2fyjA was found.

Predicted Domain #5
Region A:
Residues: [1228-1461] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DELNCGTDSS TMNISCAEDQ YQCTSNLKIC LPSTVRCNGT TECPRGEDEA DCGDVCSIYE  60
   61 FKCRSGRECI RREFRCDGQK DCGDGSDELS CELEKGHHNQ SQIQPWSTSS RSCRPHLFDC 120
  121 QDGECVDLSR VCNNFPDCTN GHDEGPKCAT ACRSASGRQV CQHKCRATPA GAVCSCFDGY 180
  181 RLDADQKSCL DIDECQEQQP CAQLCENTLG GYQCQCHADF MLRQDRVSCK SLQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1jv2B
Description: Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1462-1845] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GATLLFSSFN EVRNLSEQPV MLNVAWSAND SRITGFDLAM HRQMGYFSAE DEGIVYQIDL  60
   61 QTKVIVRALG LPAPTKLSVD WVTGNVYVLS GAQEIQACSF VGRMCGRIVH VKSPRHVKHL 120
  121 AVDGYHARIF YIVIRTEGYG QTSSEIHMAR LDGSRRDMLL QRSESFMTAL TTDPHQQLLY 180
  181 FVDQHMRTLE RISYRLKTGP MRRPEIMLQK SNALMHPSGL SVYENNAFIV NLGSVEAVQC 240
  241 ALYGSRICHK ISINVLNAQD IVVAGRSRQP QKASHPCAHA HCHGLCLQAD YGYECMCGNR 300
  301 LVAEGERCPH GSGNEVAVLG AVNSLELEHE HEQNGHFHWL MALFVLAAGS LIAGLGYMYY 360
  361 QYRQRGHTDL NINMHFQNPL ATLG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.78
Match: 1ijqA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1846-1984] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTKAFLEHER AEAGVGFTTE TGTVSSRGSN DTFTTTSATS SFAAQQFSVP NALQRLLRPR  60
   61 QSASGDPMAQ ELLLESPSRE SKLHALDGGG AGGDGDGGRG VGRQVPDILV ADMDDDAAKS 120
  121 AGQFGGNYAG NDANARFVS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle