Protein Overview: S100A12

General Information:
Name(s) found:	S100A12 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|20149880\|pdb\|1GQM\|L Chain L, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149879\|pdb\|1GQM\|K Chain K, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149878\|pdb\|1GQM\|J Chain J, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149877\|pdb\|1GQM\|I Chain I, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149876\|pdb\|1GQM\|H Chain H, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149875\|pdb\|1GQM\|G Chain G, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149874\|pdb\|1GQM\|F Chain F, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149873\|pdb\|1GQM\|E Chain E, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149872\|pdb\|1GQM\|D Chain D, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149871\|pdb\|1GQM\|C Chain C, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149870\|pdb\|1GQM\|B Chain B, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|20149869\|pdb\|1GQM\|A Chain A, The Structure Of S100a12 In A Hexameric Form [NCBI NR] gi\|13096754\|pdb\|1E8A\|B Chain B, The Three-Dimensional Structure Of Human S100a12 [NCBI NR] gi\|13096753\|pdb\|1E8A\|A Chain A, The Three-Dimensional Structure Of Human S100a12 [NCBI NR] S100 calcium binding protein A12 [HGNC (HUGO)] (P80511) Calgranulin C (CAGC) (CGRP) (Neutrophil S100 protein) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (p6) [Contains: Calcitermin] [Swiss-Prot] (P80511) Protein S100-A12 (S100 calcium-binding protein A12) (Calgranulin-C) (CAGC) (CGRP) (Neutrophil S100 protein) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (p6) [Contains: Calcitermin] [Swiss-Prot] Chain B, The Three-Dimensional Structure Of Human S100a12gi\|13096753\|pdb\|1E8A\|A Chain A, The Three-Dimensional Structure Of Human S100a12gi\|20149880\|pdb\|1GQM\|L Chain L, The Structure Of S100a12 In A Hexameric Formgi\|20149879\|pdb\|1GQM\|K Chain K, The Str [nrdb_11152004_Chlamydomonas] Tax_Id=9606 Protein S100-A12 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] Tax_Id=9606 Calgranulin C [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta] Chain L, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain K, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain J, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain I, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain H, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain G, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain F, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain E, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain D, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain C, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain B, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain A, The Structure Of S100a12 In A Hexameric Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain B, The Three-Dimensional Structure Of Human S100a12 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Chain A, The Three-Dimensional Structure Of Human S100a12 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
Organism:	Homo sapiens
Length:	91 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 TKLEEHLEGI VNIFHQYSVR KGHFDTLSKG ELKQLLTKEL ANTIKNIKDK AVIDEIFQGL 60 61 DANQDEQVDF QEFISLVAIA LKAAHYHTHK E

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Noble WS, et al. (2009) Manuscript in preparation.		S100A12 gi\|112491310 gi\|13786858 gi\|150261449 gi\|219109210, gi...

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..91]	PSI-BLAST	21.0	Calcyclin (S100)

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
binding	3.17556402087346	bayes_pls_golite062009
metal ion binding	2.62077305565026	bayes_pls_golite062009
cation binding	2.62077305565026	bayes_pls_golite062009
ion binding	2.61312132078717	bayes_pls_golite062009
calcium-dependent protein binding	2.41193763776922	bayes_pls_golite062009
protein binding	2.21291432166051	bayes_pls_golite062009
structural molecule activity	2.02132683356917	bayes_pls_golite062009
transcription regulator activity	1.82714164083189	bayes_pls_golite062009
S100 beta binding	1.55177531533958	bayes_pls_golite062009
nucleic acid binding	1.43263098461462	bayes_pls_golite062009
peptidase activity	1.42397628411744	bayes_pls_golite062009
calcium ion binding	1.40919295397643	bayes_pls_golite062009
DNA binding	1.40714762620388	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	1.15266823079004	bayes_pls_golite062009
signal transducer activity	1.11607939838219	bayes_pls_golite062009
molecular transducer activity	1.11607939838219	bayes_pls_golite062009
cytoskeletal protein binding	1.11378356087757	bayes_pls_golite062009
structural constituent of muscle	1.04858159053187	bayes_pls_golite062009
receptor binding	0.857448001471136	bayes_pls_golite062009
endopeptidase activity	0.833336205861396	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.787740261079819	bayes_pls_golite062009
kinase activity	0.782396352346639	bayes_pls_golite062009
transporter activity	0.751717017963896	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.654002071540024	bayes_pls_golite062009
transmembrane transporter activity	0.573179802647827	bayes_pls_golite062009
myosin heavy chain binding	0.46116030951749	bayes_pls_golite062009
enzyme inhibitor activity	0.198231331358135	bayes_pls_golite062009
substrate-specific transporter activity	0.118606503254753	bayes_pls_golite062009
actin binding	0.113835617777946	bayes_pls_golite062009
hydrolase activity	0.0468413224205481	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

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