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View Structure Prediction Details

Protein: S100A12
Organism: Homo sapiens
Length: 91 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for S100A12.

Description E-value Query
Range
Subject
Range
gi|109016674 - gi|109016674|ref|XP_001108718.1| PREDICTED: similar to Protein S100-A11 (S100 calcium-binding protei...
129.0 [0..1] [90..441]
gi|76612513 - gi|76612513|ref|XP_595126.2| PREDICTED: similar to Calgizzarin (S100 calcium-binding protein A11) (S...
127.0 [0..1] [90..87]
gi|50761685 - gi|50761685|ref|XP_429152.1| PREDICTED: similar to S100Z protein [Gallus gallus]
124.0 [0..1] [91..369]
gi|34811430, gi|... - gi|34811430|pdb|1NSH|B Chain B, Solution Structure Of Rabbit Apo-S100a11 (19 Models), gi|34811429|pd...
119.0 [0..1] [90..4]
gi|109504576 - gi|109504576|ref|XP_225088.3| PREDICTED: similar to S100 calcium binding protein A11 [Rattus norvegi...
119.0 [0..2] [90..64]
gi|56205585, gi|... - gi|56205585|emb|CAI19674.1| S100 calcium binding protein A1 [Homo sapiens], gi|119573686|gb|EAW53301...
117.0 [0..1] [88..56]
gi|114559755 - gi|114559755|ref|XP_513820.2| PREDICTED: S100 calcium binding protein A1 isoform 2 [Pan troglodytes]
117.0 [0..1] [88..56]
gi|60829601, gi|... - gi|61371878|gb|AAX43748.1| S100 calcium binding protein A11 [synthetic construct], gi|61369077|gb|AA...
117.0 [0..1] [90..8]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKLEEHLEGI VNIFHQYSVR KGHFDTLSKG ELKQLLTKEL ANTIKNIKDK AVIDEIFQGL  60
   61 DANQDEQVDF QEFISLVAIA LKAAHYHTHK E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1odbA
Description: Calcyclin (S100)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.17556402087346 bayes_pls_golite062009
metal ion binding 2.62077305565026 bayes_pls_golite062009
cation binding 2.62077305565026 bayes_pls_golite062009
ion binding 2.61312132078717 bayes_pls_golite062009
calcium-dependent protein binding 2.41193763776922 bayes_pls_golite062009
protein binding 2.21291432166051 bayes_pls_golite062009
structural molecule activity 2.02132683356917 bayes_pls_golite062009
transcription regulator activity 1.82714164083189 bayes_pls_golite062009
S100 beta binding 1.55177531533958 bayes_pls_golite062009
nucleic acid binding 1.43263098461462 bayes_pls_golite062009
peptidase activity 1.42397628411744 bayes_pls_golite062009
calcium ion binding 1.40919295397643 bayes_pls_golite062009
DNA binding 1.40714762620388 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.15266823079004 bayes_pls_golite062009
signal transducer activity 1.11607939838219 bayes_pls_golite062009
molecular transducer activity 1.11607939838219 bayes_pls_golite062009
cytoskeletal protein binding 1.11378356087757 bayes_pls_golite062009
structural constituent of muscle 1.04858159053187 bayes_pls_golite062009
receptor binding 0.857448001471136 bayes_pls_golite062009
endopeptidase activity 0.833336205861396 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.787740261079819 bayes_pls_golite062009
kinase activity 0.782396352346639 bayes_pls_golite062009
transporter activity 0.751717017963896 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.654002071540024 bayes_pls_golite062009
transmembrane transporter activity 0.573179802647827 bayes_pls_golite062009
myosin heavy chain binding 0.46116030951749 bayes_pls_golite062009
enzyme inhibitor activity 0.198231331358135 bayes_pls_golite062009
substrate-specific transporter activity 0.118606503254753 bayes_pls_golite062009
actin binding 0.113835617777946 bayes_pls_golite062009
hydrolase activity 0.0468413224205481 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle