Protein Overview: PTN6_RAT

General Information:
Name(s) found:	PTN6_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|4098327\|gb\|AAD00262.1\| protein-tyrosine phosphatase [Rattus norvegicus] [NCBI NR] gi\|34922906\|sp\|P81718.1\|PTN6_RAT RecName: Full=Tyrosine-protein phosphatase non-receptor type 6; AltName: Full=Protein-tyrosine phosphatase SHP-1 [NCBI NR] gi\|16758788\|ref\|NP_446360.1\| protein tyrosine phosphatase, non-receptor type 6 [Rattus norvegicus] [NCBI NR] Tyrosine-protein phosphatase non-receptor type 6 OS=Rattus norvegicus GN=Ptpn6 PE=1 SV=1 [Swiss-Prot] protein tyrosine phosphatase, non-receptor type 6 [HMR_022704-rand.fasta] protein tyrosine phosphatase, non-receptor type 6 [Rattus norvegicus]gi\|34922906\|sp\|P81718\|PTN6_RAT Protein-tyrosine phosphatase, non-receptor type 6 (Protein-tyrosine phosphatase SHP-1)gi\|4098327\|gb\|AAD00262.1\| protein-tyrosine phosphatase [Rattus norv [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Tyrosine-protein phosphatase non-receptor type 6 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Tyrosine-protein phosphatase, non-receptor type 6 [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] (NM_053908) protein tyrosine phosphatase, non-receptor type 6 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Tyrosine-protein phosphatase non-receptor type 6 (Protein-tyrosine phosphatase SHP-1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] protein tyrosine phosphatase, non-receptor type 6 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] protein-tyrosine phosphatase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Ptpn6 Tyrosine-protein phosphatase non-receptor type 6 [rat-ipi-250309-contam.fasta] Tyrosine-protein phosphatase non-receptor type 6 OS=Rattus norvegicus GN=Ptpn6 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	613 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IEA] cytoplasm [UNKNOWN][IEA] cytosol [UNKNOWN] alpha-beta T cell receptor complex [UNKNOWN][IEA]
Biological Process:	intracellular signaling pathway [UNKNOWN][IEA] negative regulation of MAP kinase activity [UNKNOWN][IEA] negative regulation of T cell receptor signaling pathway [UNKNOWN][IEA] negative regulation of MAPKKK cascade [UNKNOWN][IEA] negative regulation of T cell proliferation [UNKNOWN][IEA] negative regulation of humoral immune response mediated by circulating immunoglobulin [UNKNOWN][IEA] protein amino acid dephosphorylation [UNKNOWN][IEA][TAS] response to wounding [IEP] regulation of B cell differentiation [UNKNOWN][IEA] natural killer cell mediated cytotoxicity [UNKNOWN][IEA] negative regulation of peptidyl-tyrosine phosphorylation [UNKNOWN][IEA] B cell receptor signaling pathway [UNKNOWN][IEA]
Molecular Function:	phosphotyrosine binding [UNKNOWN][IEA] protein binding [UNKNOWN][IEA] protein tyrosine phosphatase activity [UNKNOWN][IEA][TAS] phosphatase activity [IEA] SH3 domain binding [UNKNOWN][IEA] SH2 domain binding [UNKNOWN][IEA] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRGWFHRD LSGPDAETLL KGRGVPGSFL ARPSRKNQGD FSLSVRVDDQ VTHIRIQNSG  60
   61 DFYDLYGGEK FATSTELVEY YTQQQGILQD RDGTIIHLKY PLNCSDPTSE RWYHGHMSGG 120
  121 QAESLLQAKG EPWTFLVRES LSQPGDFVLS VLNDQPKAAP GSPLRVTHIK VMCEGGRYTV 180
  181 GGSETFDSLT DLVEHFKKTG IEEASGAFVY LRQPYYATRV NAADIENRVL ELNKKQESED 240
  241 TAKAGFWEEF ESLQKQEAKN LHQRLEGQRP ENKSKNRYKN ILPFDHSRVI LQGRDSNIPG 300
  301 SDYINANYVK NQLLGPDENS KTYIASQGCL DATVNDFWQM AWQENTRVIV MTTREVEKGR 360
  361 NKCVPYWPEV GTQRVYGLYS VTNCKEHDTA EYKLRTLQIS PLDNGDLVRE IWHYQYLSWP 420
  421 DHGVPSEPGG VLSFLDQINQ RQESLPHAGP IIVHCSAGIG RTGTIIVIDM LMESVSTKGL 480
  481 DCDIDIQKTI QMVRAQRSGM VQTEAQYKFI YVAIAQFIET TKKKLEIIQS QRGQESEYGN 540
  541 ITYPPALRSA HAKASRTSSK HKEEVYENVH SKNKKEEKVK KQRSADKEKN KGSLKRNISL 600
  601 TPCRGLRWAD RDL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Protein Overview: PTN6_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: