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Protein Overview: Pcd-PA

General Information:
Name(s) found: Pcd-PA / FBpp0084824 [FlyBase]
Description(s) found:
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  • gi|51338717|sp|O76454.2|PHS_DROME RecName: Full=Pterin-4-alpha-carbinolamine dehydratase; Short=PHS; AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase; AltName: Full=Pterin carbinolamine dehydratase; Short=PCD [NCBI NR]
  • gi|45549100|ref|NP_477360.2| pterin-4a-carbinolamine dehydratase [Drosophila melanogaster] [NCBI NR]
  • gi|45446702|gb|AAF56923.2| pterin-4a-carbinolamine dehydratase [Drosophila melanogaster] [NCBI NR]
  • gi|254939747|gb|ACT88136.1| GH23826p [Drosophila melanogaster] [NCBI NR]
  • Pterin-4-alpha-carbinolamine dehydratase OS=Drosophila melanogaster GN=Pcd PE=1 SV=2 [Swiss-Prot]
  • The gene pterin-4a-carbinolamine dehydratase is referred to in FlyBase by the symbol Dmel\Pcd (CG1963, FBgn0024841). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:25548883..25549948. It has the cytological map location 99B9. Based on sequence similarity, it is predicted to have molecular function</span>: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: tetrahydrobiopterin biosynthetic process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • (AAF56923) CG1963-PA [DrosMelano7227.FASTAC.txt]
  • CG1963-PA [Drosophila melanogaster]gi|45549100|ref|NP_477360.2| CG1963-PA [Drosophila melanogaster]gi|51338717|sp|O76454|PHS_DROME Pterin-4-alpha-carbinolamine dehydratase (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydr [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(25548951..25549078,25549160..25549310,25549569..25549868); ID=FBpp0084824; name=Pcd-PA; parent=FBgn0024841,FBtr0085458; dbxref=GB_protein:AAF56923.1,FlyBase:FBpp0084824,FlyBase_Annotation_IDs:CG1963-PA,GB_protein:AAF56923.2,REFSE [fly-100309-contam.fasta]
  • pterin-4a-carbinolamine dehydratase CG1963-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1963-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Pterin-4-alpha-carbinolamine dehydratase (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD) [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(25548951..25549078,25549160..25549310,25549569..25549868); ID=FBpp0084824; name=Pcd-PA; parent=FBgn0024841,FBtr0085458; dbxref=GB_protein:AAF56923.1,FlyBase:FBpp0084824,FlyBase_Annotation_IDs:CG1963-PA,GB_protein:AAF56923.2,REFSEQ:NP_477360,GB_protein:AAF56923; MD5=926781eba1b9b9941a10e52a588ce8ba; length=192; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(25548951..25549078,25549160..25549310,25549569..25549868); ID=FBpp0084824; name=Pcd-PA; parent=FBgn0024841,FBtr0085458; dbxref=GB_protein:AAF56923.1,FlyBase:FBpp0084824,FlyBase_Annotation_IDs:CG1963-PA,GB_protein:AAF56923.2,REFSEQ:NP_477360,GB_protein:AAF56923; MD5=926781eba1b9b9941a10e52a588ce8ba; length=192; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(25548951..25549078,25549160..25549310,25549569..25549868); ID=FBpp0084824; name=Pcd-PA; parent=FBgn0024841,FBtr0085458; dbxref=GB_protein:AAF56923.1,FlyBase:FBpp0084824,FlyBase_Annotation_IDs:CG1963-PA,GB_protein:AAF56923.2,REFSEQ:NP_477360,GB_protein:AAF56923,FlyMine:FBpp0084824,modMine:FBpp0084824; MD5=926781eba1b9b9941a10e52a588ce8ba; length=192; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(29723229..29723356,29723438..29723588,29723847..29724146); ID=FBpp0084824; name=Pcd-PA; parent=FBgn0024841,FBtr0085458; dbxref=GB_protein:AAF56923.1,FlyBase:FBpp0084824,FlyBase_Annotation_IDs:CG1963-PA,GB_protein:AAF56923.2,REFSEQ:NP_477360,GB_protein:AAF56923,FlyMine:FBpp0084824,modMine:FBpp0084824; MD5=926781eba1b9b9941a10e52a588ce8ba; length=192; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(29723229..29723356,29723438..29723588,29723847..29724146); ID=FBpp0084824; name=Pcd-PA; parent=FBgn0024841,FBtr0085458; dbxref=GB_protein:AAF56923.1,FlyBase:FBpp0084824,FlyBase_Annotation_IDs:CG1963-PA,GB_protein:AAF56923.2,REFSEQ:NP_477360,GB_protein:AAF56923,FlyMine:FBpp0084824,modMine:FBpp0084824; MD5=926781eba1b9b9941a10e52a588ce8ba; length=192; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0084824 type=protein; loc=3R:join(29723229..29723356,29723438..29723588,29723847..29724146); ID=FBpp0084824; name=Pcd-PA; parent=FBgn0024841,FBtr0085458; dbxref=GB_protein:AAF56923.1,FlyBase:FBpp0084824,FlyBase_Annotation_IDs:CG1963-PA,GB_protein:AAF56923.2,REFSEQ:NP_477360,GB_protein:AAF56923,FlyMine:FBpp0084824,modMine:FBpp0084824; MD5=926781eba1b9b9941a10e52a588ce8ba; length=192; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(29723229..29723356,29723438..29723588,29723847..29724146); ID=FBpp0084824; name=Pcd-PA; parent=FBgn0024841,FBtr0085458; dbxref=GB_protein:AAF56923.1,FlyBase:FBpp0084824,FlyBase_Annotation_IDs:CG1963-PA,GB_protein:AAF56923.2,REFSEQ:NP_477360,GB_protein:AAF56923,UniProt/Swiss-Prot:O76454,FlyMine:FBpp0084824,modMine:FBpp0084824; MD5=926781eba1b9b9941a10e52a588ce8ba; length=192; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 192 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: tetrahydrobiopterin biosynthetic process [ISS]
    Molecular Function: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLTIKCAQN VIKPNCQKVA NLLASSRRAG LFPTTATTAT SRSLSQISVL YSPAAREAAR  60
   61 AATGGSANLR RIHNTPTTEA TATAITAKKR KMVVRLNEQE RAEKLQPLLD AGWTLVEGRD 120
  121 AIFKQFVLKD FNQAFSFMTG VALLAEKINH HPEWFNCYNK VDVTLSTHDV GGLSSQDIRM 180
  181 ATHLETTANL LK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] deduced N/A No confident structure predictions are available.
    2 View Details [92..192] PSI-BLAST 36.221849 Crystal structure of DCoH2, a paralog of DCoH, the Dimerization Cofactor of HNF-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • 4-alpha-hydroxytetrahydrobiopterin dehydratase activity
    		•  6.27157822952381 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.43253022834875 bayes_pls_golite062009
  • phenylalanine 4-monooxygenase activity
    		•  2.07153680701772 bayes_pls_golite062009
  • binding
    		•  1.91757396487631 bayes_pls_golite062009
  • transcription activator activity
    		•  1.76965686339133 bayes_pls_golite062009
  • protein binding
    		•  1.5922433129317 bayes_pls_golite062009
  • catalytic activity
    		•  1.39967796334655 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
    		•  1.1107181321593 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.738746392707103 bayes_pls_golite062009
  • hydro-lyase activity
    		•  0.699903508958642 bayes_pls_golite062009
  • lyase activity
    		•  0.685050647082958 bayes_pls_golite062009
  • transcription factor binding
    		•  0.303837517417996 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle