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View Structure Prediction Details

Protein: Pcd-PA
Organism: Drosophila melanogaster
Length: 192 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pcd-PA.

Description E-value Query
Range
Subject
Range
gi|73971304 - gi|73971304|ref|XP_852425.1| PREDICTED: similar to dimerization cofactor of hepatocyte nuclear facto...
168.0 [0..44] [189..1]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLTIKCAQN VIKPNCQKVA NLLASSRRAG LFPTTATTAT SRSLSQISVL YSPAAREAAR  60
   61 AATGGSANLR RIHNTPTTEA TATAITAKKR K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-192]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVRLNEQER AEKLQPLLDA GWTLVEGRDA IFKQFVLKDF NQAFSFMTGV ALLAEKINHH  60
   61 PEWFNCYNKV DVTLSTHDVG GLSSQDIRMA THLETTANLL K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.221849
Match: 1ru0A
Description: Crystal structure of DCoH2, a paralog of DCoH, the Dimerization Cofactor of HNF-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4-alpha-hydroxytetrahydrobiopterin dehydratase activity 6.27157822952381 bayes_pls_golite062009
transcription regulator activity 2.43253022834875 bayes_pls_golite062009
phenylalanine 4-monooxygenase activity 2.07153680701772 bayes_pls_golite062009
binding 1.91757396487631 bayes_pls_golite062009
transcription activator activity 1.76965686339133 bayes_pls_golite062009
protein binding 1.5922433129317 bayes_pls_golite062009
catalytic activity 1.39967796334655 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen 1.1107181321593 bayes_pls_golite062009
carbon-oxygen lyase activity 0.738746392707103 bayes_pls_golite062009
hydro-lyase activity 0.699903508958642 bayes_pls_golite062009
lyase activity 0.685050647082958 bayes_pls_golite062009
transcription factor binding 0.303837517417996 bayes_pls_golite062009

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