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View Structure Prediction Details

Protein: Pcd-PA
Organism: Drosophila melanogaster
Length: 192 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Pcd-PA.

Description E-value Query
Range
Subject
Range
gi|73971304 - gi|73971304|ref|XP_852425.1| PREDICTED: similar to dimerization cofactor of hepatocyte nuclear facto...
168.0 [0..44] [189..1]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLTIKCAQN VIKPNCQKVA NLLASSRRAG LFPTTATTAT SRSLSQISVL YSPAAREAAR  60
   61 AATGGSANLR RIHNTPTTEA TATAITAKKR K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-192]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVRLNEQER AEKLQPLLDA GWTLVEGRDA IFKQFVLKDF NQAFSFMTGV ALLAEKINHH  60
   61 PEWFNCYNKV DVTLSTHDVG GLSSQDIRMA THLETTANLL K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.221849
Match: 1ru0A
Description: Crystal structure of DCoH2, a paralog of DCoH, the Dimerization Cofactor of HNF-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4-alpha-hydroxytetrahydrobiopterin dehydratase activity 6.27157822952381 bayes_pls_golite062009
transcription regulator activity 2.43253022834875 bayes_pls_golite062009
phenylalanine 4-monooxygenase activity 2.07153680701772 bayes_pls_golite062009
binding 1.91757396487631 bayes_pls_golite062009
transcription activator activity 1.76965686339133 bayes_pls_golite062009
protein binding 1.5922433129317 bayes_pls_golite062009
catalytic activity 1.39967796334655 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen 1.1107181321593 bayes_pls_golite062009
carbon-oxygen lyase activity 0.738746392707103 bayes_pls_golite062009
hydro-lyase activity 0.699903508958642 bayes_pls_golite062009
lyase activity 0.685050647082958 bayes_pls_golite062009
transcription factor binding 0.303837517417996 bayes_pls_golite062009

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