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Protein Overview: MSX2_RAT

General Information:
Name(s) found: MSX2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|6981226|ref|NP_037114.1| msh homeobox 2 [Rattus norvegicus] [NCBI NR]
  • gi|529694|gb|AAA20669.1| MSX-2 [NCBI NR]
  • gi|1709146|sp|P52953.1|MSX2_RAT RecName: Full=Homeobox protein MSX-2; AltName: Full=Hox-8.1 [NCBI NR]
  • Homeobox protein MSX-2 (Fragment) OS=Rattus norvegicus GN=Msx2 PE=3 SV=1 [Swiss-Prot]
  • msh homeo box homolog 2; Msh (Drosophila) homeo box homolog [HMR_022704-rand.fasta]
  • msh homeo box homolog 2 [Rattus norvegicus]gi|1709146|sp|P52953|MSX2_RAT Homeobox protein MSX-2 (Hox-8.1)gi|529694|gb|AAA20669.1| MSX-2 [nrdb_11152004_Chlamydomonas]
  • (NM_012982) msh (Drosophila) homeo box homolog [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Homeobox protein MSX-2 (Hox-8.1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • MSX-2 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • msh homeobox 2 [Rattus norvegicus] [nr-271106-contam.fasta]
  • Homeobox protein MSX-2 (Fragment) OS=Rattus norvegicus GN=Msx2 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 139 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IEA]
    cellular_component [ND]
    Biological Process: multicellular organismal development [IEA]
    negative regulation of cell proliferation [UNKNOWN][IEA]
    regulation of transcription, DNA-dependent [IEA]
    regulation of apoptosis [UNKNOWN]
    heart development [UNKNOWN]
    embryonic limb morphogenesis [UNKNOWN][IEA]
    heart morphogenesis [UNKNOWN][IEA]
    cellular response to estradiol stimulus [UNKNOWN]
    BMP signaling pathway [UNKNOWN][IEA]
    negative regulation of apoptosis [UNKNOWN][IEA]
    cellular response to growth factor stimulus [UNKNOWN]
    positive regulation of apoptosis [IMP]
    osteoblast differentiation [ISS]
    cellular response to protein stimulus [UNKNOWN]
    response to protein stimulus [UNKNOWN][IEA]
    Molecular Function: transcription factor activity [IEA]
    protein binding [UNKNOWN][IEA]
    sequence-specific DNA binding [UNKNOWN]
    promoter binding [ISS]
    transcription repressor activity [ISS]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPTTCTLRK HKTNRKPRTP FTTSQLLALE RKFRQKQYLS IAERAEFSSS LNLTETQVKI  60
   61 WFQNRRAKAK RLQEAELEKL KMAAKPMLPS GFSLPFPINS PLQAASIYSA SYPFHRPVLP 120
  121 IPPVGLYATP VGYGMYHLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..139] PSI-BLAST 15.0 VND/NK-2 protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.09839603329852 bayes_pls_golite062009
  • DNA binding
    		•  3.70287146988839 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.64380968064654 bayes_pls_golite062009
  • transcription factor activity
    		•  3.09799997792958 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.67989581172015 bayes_pls_golite062009
  • binding
    		•  2.38790799849051 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.24140562598253 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.50388788083093 bayes_pls_golite062009
  • transcription activator activity
    		•  0.868489910606103 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.83458785143486 bayes_pls_golite062009
  • chromatin binding
    		•  0.806325172844419 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.657260016132472 bayes_pls_golite062009
  • transcription factor binding
    		•  0.54291661516816 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.012862302676295 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle