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Protein Overview: HDHA_ECOLI

General Information:
Name(s) found: HDHA_ECOLI [Swiss-Prot]
Description(s) found:
Found 29 descriptions.
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  • 7-alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) (7-alpha-HSDH) - Escherichia coli [Swiss-Prot]
    • Organism: Escherichia coli
    Length: 255 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNSDNLRLD GKCAIITGAG AGIGKEIAIT FATAGASVVV SDINADAANH VVDEIQQLGG  60
   61 QAFACRCDIT SEQELSALAD FAISKLGKVD ILVNNAGGGG PKPFDMPMAD FRRAYELNVF 120
  121 SFFHLSQLVA PEMEKNGGGV ILTITSMAAE NKNINMTSYA SSKAAASHLV RNMAFDLGEK 180
  181 NIRVNGIAPG AILTDALKSV ITPEIEQKML QHTPIRRLGQ PQDIANAALF LCSPAASWVS 240
  241 GQILTVSGGG VQELN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. HDHA_ECOLI gi|134105085, gi... gi|189095939, gi... gi|60594470, gi|...

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..255] PSI-BLAST 60.69897 7-alpha-hydroxysteroid dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  3.06391460989761 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  3.02758902218302 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  2.66329970371321 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  2.50453100919665 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.81060491890041 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • retinoid binding
    		•  1.72614743805853 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.61095405873981 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • alcohol binding
    		•  1.07158175924364 bayes_pls_golite062009
  • sorbose reductase activity
    		•  1.06293597394863 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  0.69372321031969 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.665447800395781 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • receptor activity
    		•  0.591732115418164 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.576163737662951 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.565177620701637 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.532187027260366 bayes_pls_golite062009
  • DNA binding
    		•  0.525227236870065 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.459537641913493 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  0.439912268968251 bayes_pls_golite062009
  • signal transducer activity
    		•  0.384212208916324 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.384212208916324 bayes_pls_golite062009
  • retinol binding
    		•  0.343379136183648 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.177044638410302 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.0913823272876781 bayes_pls_golite062009
  • ethanol binding
    		•  0.0448614072391299 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.00644214957417527 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle