Protein Overview: dlg1-PB

General Information:
Name(s) found:	dlg1-PB / FBpp0089351 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|51704269\|sp\|P31007.2\|DLG1_DROME RecName: Full=Disks large 1 tumor suppressor protein [NCBI NR] gi\|45554813\|ref\|NP_996406.1\| discs large 1, isoform B [Drosophila melanogaster] [NCBI NR] gi\|45446905\|gb\|AAS65308.1\| discs large 1, isoform B [Drosophila melanogaster] [NCBI NR] Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 [Swiss-Prot] The gene discs large 1 is referred to in FlyBase by the symbol Dmel\dlg1 (CG1725, FBgn0001624). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11263670..11301784. It has the cytological map location 10B6-10B10. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 15 unique biological process</span> terms, many of which group under: anatomical structure development; macromolecule localization; protein localization; mating; locomotory behavior; system development; nervous system development; organ morphogenesis; behavioral interaction between organisms; reproductive process in a multicellular organism; organelle organization; synaptic transmission; basal protein localization; taxis; establishment or maintenance of polarity of follicular epithelium. 80 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: organ system; nervous system; embryonic nervous system; multi-cell-component structure; peripheral nervous system; plasma membrane part; adult segment; imaginal precursor; female germline cyst; plasma membrane; cuticle. It has 15 annotated transcripts and 15 annotated polypeptides. [FlyBase] (AAS65308) CG1725-PB [DrosMelano7227.FASTAC.txt] CG1725-PB, isoform B [Drosophila melanogaster]gi\|45554813\|ref\|NP_996406.1\| CG1725-PB [Drosophila melanogaster]gi\|51704269\|sp\|P31007\|DLG1_DROME Discs large-1 tumor suppressor protein [nrdb_11152004_Chlamydomonas] type=protein; loc=X:join(11268525..11268543,11270875..11271006,11275889..11276013,11276969..11277145,11281805..11281966,11289273..11289824,11289887..11290136,11291858..11291945,11292003..11292216,11292279..11292692,11292753..11292855,11294821..11294865,11 [fly-100309-contam.fasta] Discs large 1 tumor suppressor protein [nr-271106-contam.fasta] CG1725-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] discs large 1 CG1725-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=X:join(11268525..11268543,11270875..11271006,11275889..11276013,11276969..11277145,11281805..11281966,11289273..11289824,11289887..11290136,11291858..11291945,11292003..11292216,11292279..11292692,11292753..11292855,11294821..11294865,11299307..11299456,11299593..11299875,11299937..11300028,11300105..11300211); ID=FBpp0089351; name=dlg1-PB; parent=FBgn0001624,FBtr0073488; dbxref=FlyBase_Annotation_IDs:CG1725-PB,FlyBase:FBpp0089351,GB_protein:AAS65308.1,REFSEQ:NP_996406,GB_protein:AAS65308; MD5=7afbbb131ec8badac87bf432730d553f; length=970; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=X:join(11268525..11268543,11270875..11271006,11275889..11276013,11276969..11277145,11281805..11281966,11289273..11289824,11289887..11290136,11291858..11291945,11292003..11292216,11292279..11292692,11292753..11292855,11294821..11294865,11299307..11299456,11299593..11299875,11299937..11300028,11300105..11300211); ID=FBpp0089351; name=dlg1-PB; parent=FBgn0001624,FBtr0073488; dbxref=FlyBase_Annotation_IDs:CG1725-PB,FlyBase:FBpp0089351,GB_protein:AAS65308.1,REFSEQ:NP_996406,GB_protein:AAS65308; MD5=7afbbb131ec8badac87bf432730d553f; length=970; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=X:join(11268525..11268543,11270875..11271006,11275889..11276013,11276969..11277145,11281805..11281966,11289273..11289824,11289887..11290136,11291858..11291945,11292003..11292216,11292279..11292692,11292753..11292855,11294821..11294865,11299307..11299456,11299593..11299875,11299937..11300028,11300105..11300211); ID=FBpp0089351; name=dlg1-PB; parent=FBgn0001624,FBtr0073488; dbxref=FlyBase_Annotation_IDs:CG1725-PB,FlyBase:FBpp0089351,GB_protein:AAS65308.1,REFSEQ:NP_996406,GB_protein:AAS65308,FlyMine:FBpp0089351,modMine:FBpp0089351; MD5=7afbbb131ec8badac87bf432730d553f; length=970; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=X:join(11374492..11374510,11376842..11376973,11381856..11381980,11382936..11383112,11387772..11387933,11395240..11395791,11395854..11396103,11397825..11397912,11397970..11398183,11398246..11398659,11398720..11398822,11400788..11400832,11405274..11405423,11405560..11405842,11405904..11405995,11406072..11406178); ID=FBpp0089351; name=dlg1-PB; parent=FBgn0001624,FBtr0073488; dbxref=FlyBase_Annotation_IDs:CG1725-PB,FlyBase:FBpp0089351,GB_protein:AAS65308.1,REFSEQ:NP_996406,GB_protein:AAS65308,FlyMine:FBpp0089351,modMine:FBpp0089351; MD5=7afbbb131ec8badac87bf432730d553f; length=970; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=X:join(11374492..11374510,11376842..11376973,11381856..11381980,11382936..11383112,11387772..11387933,11395240..11395791,11395854..11396103,11397825..11397912,11397970..11398183,11398246..11398659,11398720..11398822,11400788..11400832,11405274..11405423,11405560..11405842,11405904..11405995,11406072..11406178); ID=FBpp0089351; name=dlg1-PB; parent=FBgn0001624,FBtr0073488; dbxref=FlyBase_Annotation_IDs:CG1725-PB,FlyBase:FBpp0089351,GB_protein:AAS65308.1,REFSEQ:NP_996406,GB_protein:AAS65308,FlyMine:FBpp0089351,modMine:FBpp0089351; MD5=7afbbb131ec8badac87bf432730d553f; length=970; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0089351 type=protein; loc=X:join(11374492..11374510,11376842..11376973,11381856..11381980,11382936..11383112,11387772..11387933,11395240..11395791,11395854..11396103,11397825..11397912,11397970..11398183,11398246..11398659,11398720..11398822,11400788..11400832,11405274..11405423,11405560..11405842,11405904..11405995,11406072..11406178); ID=FBpp0089351; name=dlg1-PB; parent=FBgn0001624,FBtr0073488; dbxref=FlyBase_Annotation_IDs:CG1725-PB,FlyBase:FBpp0089351,GB_protein:AAS65308.1,REFSEQ:NP_996406,GB_protein:AAS65308,FlyMine:FBpp0089351,modMine:FBpp0089351; MD5=7afbbb131ec8badac87bf432730d553f; length=970; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=X:join(11374492..11374510,11376842..11376973,11381856..11381980,11382936..11383112,11387772..11387933,11395240..11395791,11395854..11396103,11397825..11397912,11397970..11398183,11398246..11398659,11398720..11398822,11400788..11400832,11405274..11405423,11405560..11405842,11405904..11405995,11406072..11406178); ID=FBpp0089351; name=dlg1-PB; parent=FBgn0001624,FBtr0073488; dbxref=FlyBase_Annotation_IDs:CG1725-PB,FlyBase:FBpp0089351,GB_protein:AAS65308.1,REFSEQ:NP_996406,GB_protein:AAS65308,UniProt/Swiss-Prot:P31007,FlyMine:FBpp0089351,modMine:FBpp0089351; MD5=7afbbb131ec8badac87bf432730d553f; length=970; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	970 amino acids
Gene Ontology:
Cellular Component:	presynaptic membrane [IDA] apicolateral plasma membrane [IDA] apical cortex [IDA] synapse [TAS] plasma membrane [IMP][NAS] cytoskeleton [NAS] terminal button [IDA] cytoplasm [NAS] postsynaptic membrane [IDA] cell cortex [IDA] membrane [TAS] septate junction [NAS][TAS] neuromuscular junction [IDA] basolateral plasma membrane [TAS]
Biological Process:	dorsal closure [NAS][TAS] cell proliferation [TAS] cytoskeleton organization [NAS] negative regulation of cell proliferation [TAS] protein localization [IMP][TAS] nervous system development [IMP] male courtship behavior [IMP] establishment of spindle orientation [IMP] positive phototaxis [IMP] asymmetric protein localization [IMP][TAS] establishment or maintenance of neuroblast polarity [TAS] locomotor rhythm [IMP] basal protein localization [IMP][NAS] establishment or maintenance of epithelial cell apical/basal polarity [NAS][TAS] establishment or maintenance of polarity of embryonic epithelium [TAS] regulation of cell cycle [NAS] morphogenesis of follicular epithelium [IMP] establishment or maintenance of polarity of follicular epithelium [IGI] morphogenesis of larval imaginal disc epithelium [TAS] establishment or maintenance of polarity of larval imaginal disc epithelium [NAS][TAS] neuron differentiation [IMP] synaptic transmission [IMP] peripheral nervous system development [IMP] regulation of cell proliferation [TAS] mating behavior [IMP] central nervous system development [IMP] morphogenesis of an epithelium [TAS] asymmetric protein localization involved in cell fate determination [TAS] septate junction assembly [TAS] zonula adherens assembly [TAS] morphogenesis of a polarized epithelium [TAS] regulation of border follicle cell delamination [TAS]
Molecular Function:	protein binding [IPI][ISS] structural molecule activity [TAS] epidermal growth factor receptor binding [TAS] guanylate kinase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVKKQEAHR ALELLEDYHA RLSEPQDRAL RIAIERVIRI FKSRLFQALL DIQEFYELTL  60
   61 LDDSKSIQQK TAETLQIATK WEKDGQAVKI ADFIKSSNLN RNCAYEFNND ASSNQTNQSA 120
  121 LNQNPIANNV SAQAQAEALS RTFKSELEEI LNQRMRIESD TENAKEPTVE QQQKQQQAQQ 180
  181 RSSRSPQQQN PQQQQGSKSR SGSQTVNGDD SWLYEDIQLE RGNSGLGFSI AGGTDNPHIG 240
  241 TDTSIYITKL ISGGAAAADG RLSINDIIVS VNDVSVVDVP HASAVDALKK AGNVVKLHVK 300
  301 RKRGTATTPA AGSAAGDARD SAASGPKVIE IDLVKGGKGL GFSIAGGIGN QHIPGDNGIY 360
  361 VTKLMDGGAA QVDGRLSIGD KLIAVRTNGS EKNLENVTHE LAVATLKSIT DKVTLIIGKT 420
  421 QHLTTSASGG GGGGLSSGQQ LSQSQSQLAT SQSQSQVHQQ QHATPMVNSQ STEPGSRYAS 480
  481 TNVLAAVPPG TPRAVSTEDI TREPRTITIQ KGPQGLGFNI VGGEDGQGIY VSFILAGGPA 540
  541 DLGSELKRGD QLLSVNNVNL THATHEEAAQ ALKTSGGVVT LLAQYRPEEY NRFEARIQEL 600
  601 KQQAALGAGG SGTLLRTTQK RSLYVRALFD YDPNRDDGLP SRGLPFKHGD ILHVTNASDD 660
  661 EWWQARRVLG DNEDEQIGIV PSKRRWERKM RARDRSVKFQ GHAAANNNLD KQSTLDRKKK 720
  721 NFTFSRKFPF MKSRDEKNED GSDQEPFMLC YTQDDANAEG ASEENVLSYE AVQRLSINYT 780
  781 RPVIILGPLK DRINDDLISE YPDKFGSCVP HTTRPKREYE VDGRDYHFVS SREQMERDIQ 840
  841 NHLFIEAGQY NDNLYGTSVA SVREVAEKGK HCILDVSGNA IKRLQVAQLY PVAVFIKPKS 900
  901 VDSVMEMNRR MTEEQAKKTY ERAIKMEQEF GEYFTGVVQG DTIEEIYSKV KSMIWSQSGP 960
  961 TIWVPSKESL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..90]	PSI-BLAST	9.0	Hetero-tetrameric L27 (Lin-2, Lin-7) domain complexes as organization platforms of supra-molecular assemblies
2	View Details	[91..204]	deduced	N/A	No confident structure predictions are available.
3	View Details	[205..321]	PSI-BLAST	23.0	PDZ3 domain of PSD-95 protein complexed with KKETPV peptide ligand
4	View Details	[322..478]	FFAS03	3.83	solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
5	View Details	[479..603]	PSI-BLAST	9.39794	Solution structure of the fourth PDZ domain of KIAA1095 protein
6	View Details	[604..970]	PSI-BLAST	57.154902	Psd-95; Guanylate kinase-like domain of Psd-95

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: dlg1-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: