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Protein Overview: tbx-8

General Information:
Name(s) found: tbx-8 / CE36891 [WormBase]
Description(s) found:
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  • WBGene00006545 locus:tbx-8 T-box transcription factor tbx-8 status:Confirmed UniProt:Q22292 protein_id:CAA82578.2 [WormBase]
  • gi|71990537|ref|NP_499287.2| T BoX family member (tbx-8) [Caenorhabditis elegans] [NCBI NR]
  • gi|51704314|sp|Q22292.3|TBX8_CAEEL RecName: Full=T-box transcription factor tbx-8 [NCBI NR]
  • gi|51011749|emb|CAA82578.2| C. elegans protein T07C4.2, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|46093411|dbj|BAD14918.1| T-box transcription factor TBX-8 [Caenorhabditis elegans] [NCBI NR]
  • T-box transcription factor tbx-8 OS=Caenorhabditis elegans GN=tbx-8 PE=2 SV=3 [Swiss-Prot]
  • Hypothetical protein T07C4.2 [Caenorhabditis elegans]gi|46093411|dbj|BAD14918.1| T-box transcription factor TBX-8 [Caenorhabditis elegans]gi|51704314|sp|Q22292|TBX8_CAEEL T-box transcription factor tbx-8 [nrdb_11152004_Chlamydomonas]
  • CE36891 WBGene00006545 locus:tbx-8 Brachyury status:Confirmed SW:Q22292 protein_id:CAA82578.2 [wormpep150.fasta]
  • 36891 WBGene00006545 locus:tbx-8 Brachyury status:Confirmed SW:Q22292 protein_id:CAA82578.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE36891 WBGene00006545 locus:tbx-8 Brachyury status:Confirmed UniProt:TBX8_CAEEL protein_id:CAA82578.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE36891 WBGene00006545 locus:tbx-8 Brachyury status:Confirmed UniProt:TBX8_CAEEL protein_id:CAA82578.2| [wormORF-contam.fasta]
  • T-box transcription factor TBX-8 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • T07C4.2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein T07C4.2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • T-box transcription factor tbx-8 [nr-271106-contam.fasta]
  • CE36891 WBGene00006545 locus:tbx-8 Brachyury status:Confirmed UniProt:Q22292 protein_id:CAA82578.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE36891 WBGene00006545 locus:tbx-8 status:Confirmed UniProt:Q22292 protein_id:CAA82578.2 T-box transcription factor tbx-8 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 315 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article][ISSLink to PubMed article]
    transcription factor complex [ISSLink to PubMed article]
    Biological Process: nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed articleLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [ISSLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    RNA polymerase II transcription factor activity, enhancer binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDQVYVTLR EDQDKLWNLF HYHKNEMIVT KSGRKMFPKL EYVVRGLTPN KLYAMMLHIE  60
   61 PSDDHRYKFS SGEWVKSGKA EKHREPKKLW HADGVRSGKE WMTNPVCFDR VKITNCAEST 120
  121 NASMIFLHSM HKYTPVMSIY ESPSESPFSV PQPSTRLVTS VRLTYTEFIA VTAYQNDAVI 180
  181 KLKIKFNPFA KGFREGSQSD RKRNSPSADD STTDESSSQV SSPQPKKSRT VSVSPPLMPR 240
  241 ILPTMIPPPP AINPLFYSLP YFSHLAATGN FPPVPFQFPF GLPCFSPMSF PTPPPSLKNV 300
  301 KKEEQEDIEQ EINVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..237] PSI-BLAST 73.0 T-box protein 3, tbx3
    2 View Details [238..315] MSA 2.171995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.42929256050781 bayes_pls_golite062009
  • DNA binding
    		•  5.31133900263778 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.16722510757739 bayes_pls_golite062009
  • transcription factor activity
    		•  4.50526425463039 bayes_pls_golite062009
  • binding
    		•  3.82913410895101 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.81812565096059 bayes_pls_golite062009
  • protein binding
    		•  2.61625563263605 bayes_pls_golite062009
  • transcription activator activity
    		•  2.56828839945617 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.23604897773023 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  1.36275472058409 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.27337392672914 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.6498675574078 bayes_pls_golite062009
  • chromatin binding
    		•  0.63177553202971 bayes_pls_golite062009
  • transcription factor binding
    		•  0.628837188707778 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.62643527396553 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.0996675597396202 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0889583851427092 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle