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Protein Overview: TRP1

General Information:
Name(s) found: TRP1 / YDR007W [SGD]
Description(s) found:
Found 34 descriptions.
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  • Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 224 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [TASLink to PubMed article]
    Biological Process: tryptophan biosynthetic process [IDALink to PubMed article][IMPLink to PubMed article][TASLink to PubMed article]
    cellular amino acid metabolic process [TASLink to PubMed article]
    Molecular Function: phosphoribosylanthranilate isomerase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVINFTGSS GPLVKVCGLQ STEAAECALD SDADLLGIIC VPNRKRTIDP VIARKISSLV  60
   61 KAYKNSSGTP KYLVGVFRNQ PKEDVLALVN DYGIDIVQLH GDESWQEYQE FLGLPVIKRL 120
  121 VFPKDCNILL SAASQKPHSF IPLFDSEAGG TGELLDWNSI SDWVGRQESP ESLHFMLAGG 180
  181 LTPENVGDAL RLNGVIGVDV SGGVETNGVK DSNKIANFVK NAKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen ARF2 TRP1 2 Unpublished Fields Lab Data
    View Screen TEL1 TRP1 1 Unpublished Fields Lab Data
    View Screen VPS64 TRP1 1 Unpublished Fields Lab Data
    View Screen THO1 TRP1 1 Unpublished Fields Lab Data
    View Screen HMG1 TRP1 1 Unpublished Fields Lab Data
    View Screen ARF3 TRP1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TRP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..224] PSI-BLAST 57.69897 N-(5'phosphoribosyl)antranilate isomerase, PRAI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • tryptophan synthase activity
    		•  2.99898167480072 bayes_pls_golite062009
  • indole-3-glycerol-phosphate synthase activity
    		•  2.98379231184807 bayes_pls_golite062009
  • phosphoribosylanthranilate isomerase activity
    		•  2.57188946638955 bayes_pls_golite062009
  • catalytic activity
    		•  2.44231061702877 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  1.80077901589281 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  1.32677036501434 bayes_pls_golite062009
  • imidazoleglycerol-phosphate synthase activity
    		•  0.567370625225674 bayes_pls_golite062009
  • lyase activity
    		•  0.258652421339738 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle