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Protein Overview: HMX1

General Information:
Name(s) found: HMX1 / YLR205C [SGD]
Description(s) found:
Found 19 descriptions.
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  • ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 317 amino acids

    Gene Ontology:
    Cellular Component: membrane [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IEPLink to PubMed article][ISSLink to PubMed article]
    heme catabolic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: peroxidase activity [IDALink to PubMed article]
    heme oxygenase (decyclizing) activity [IDALink to PubMed article][IEPLink to PubMed article][ISSLink to PubMed article]
    heme binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDSSNTIIP SPTDVGALAN RINFQTRDAH NKINTFMGIK MAIAMRHGFI YRQGILAYYY  60
   61 VFDAIEQEID RLLNDPVTEE ELQTSTILKQ FWLEDFRRST QIYKDLKLLY SNTFKSTESL 120
  121 NEFLATFQKP PLLQQFINNI HENIHKEPCT ILSYCHVLYL ALFAGGKLIR SNLYRRLGLF 180
  181 PNFEKLSQKE LVKKGTNFFT FSDLGPTEET RLKWEYKKNY ELATRTELTE AQKLQIISVA 240
  241 EGIFDWNFNI VAEIGELNRR ELMGKFSFKC ITYLYEEWMF NKDSATRRAL HTVMLLVLSI 300
  301 IAIWVLYFLV KSFLSIV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen LOS1 HMX1 1 Unpublished Fields Lab Data
    View Screen NAF1 HMX1 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..317] PSI-BLAST 60.522879 Heme oxygenase-1 (HO-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • heme oxygenase (decyclizing) activity
    		•  6.01769064893884 bayes_pls_golite062009
  • phospholipase D activity
    		•  1.4947586862989 bayes_pls_golite062009
  • binding
    		•  1.17561038899526 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  1.04224985135083 bayes_pls_golite062009
  • catalytic activity
    		•  0.476060647762462 bayes_pls_golite062009
  • protein binding
    		•  0.338386262372183 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle